1E3D
[NiFe] Hydrogenase from Desulfovibrio desulfuricans ATCC 27774
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008901 | molecular_function | ferredoxin hydrogenase activity |
| A | 0009055 | molecular_function | electron transfer activity |
| A | 0009061 | biological_process | anaerobic respiration |
| A | 0009375 | cellular_component | ferredoxin hydrogenase complex |
| A | 0016020 | cellular_component | membrane |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0042597 | cellular_component | periplasmic space |
| A | 0044569 | cellular_component | [Ni-Fe] hydrogenase complex |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0047806 | molecular_function | cytochrome-c3 hydrogenase activity |
| A | 0051536 | molecular_function | iron-sulfur cluster binding |
| A | 0051538 | molecular_function | 3 iron, 4 sulfur cluster binding |
| A | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| B | 0008901 | molecular_function | ferredoxin hydrogenase activity |
| B | 0016151 | molecular_function | nickel cation binding |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0008901 | molecular_function | ferredoxin hydrogenase activity |
| C | 0009055 | molecular_function | electron transfer activity |
| C | 0009061 | biological_process | anaerobic respiration |
| C | 0009375 | cellular_component | ferredoxin hydrogenase complex |
| C | 0016020 | cellular_component | membrane |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0042597 | cellular_component | periplasmic space |
| C | 0044569 | cellular_component | [Ni-Fe] hydrogenase complex |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0047806 | molecular_function | cytochrome-c3 hydrogenase activity |
| C | 0051536 | molecular_function | iron-sulfur cluster binding |
| C | 0051538 | molecular_function | 3 iron, 4 sulfur cluster binding |
| C | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| D | 0008901 | molecular_function | ferredoxin hydrogenase activity |
| D | 0016151 | molecular_function | nickel cation binding |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 901 |
| Chain | Residue |
| B | GLU52 |
| B | LEU488 |
| B | HIS542 |
| B | HOH2070 |
| B | HOH2355 |
| B | HOH2358 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG D 901 |
| Chain | Residue |
| D | HOH2043 |
| D | HOH2299 |
| D | HOH2300 |
| D | GLU52 |
| D | LEU488 |
| D | HIS542 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE F3S A 267 |
| Chain | Residue |
| A | ASN228 |
| A | CYS230 |
| A | PHE235 |
| A | TRP240 |
| A | PRO241 |
| A | CYS248 |
| A | ILE249 |
| A | CYS251 |
| B | LYS222 |
| B | GLN227 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SF4 A 268 |
| Chain | Residue |
| A | HIS187 |
| A | CYS190 |
| A | ARG192 |
| A | ARG193 |
| A | CYS215 |
| A | LEU216 |
| A | CYS221 |
| site_id | AC5 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE FSX A 269 |
| Chain | Residue |
| A | GLU16 |
| A | CYS17 |
| A | THR18 |
| A | GLY19 |
| A | CYS20 |
| A | GLU75 |
| A | THR113 |
| A | CYS114 |
| A | GLY149 |
| A | CYS150 |
| A | PRO151 |
| A | HOH2122 |
| B | HIS225 |
| site_id | AC6 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE FNE B 543 |
| Chain | Residue |
| B | CYS71 |
| B | CYS74 |
| B | HIS78 |
| B | VAL467 |
| B | SER468 |
| B | ARG469 |
| B | LEU472 |
| B | VAL490 |
| B | PRO491 |
| B | THR492 |
| B | CYS536 |
| B | CYS539 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE F3S C 267 |
| Chain | Residue |
| C | THR226 |
| C | ASN228 |
| C | CYS230 |
| C | PHE235 |
| C | TRP240 |
| C | CYS248 |
| C | ILE249 |
| C | CYS251 |
| D | LYS222 |
| D | GLN227 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SF4 C 268 |
| Chain | Residue |
| C | HIS187 |
| C | CYS190 |
| C | ARG192 |
| C | ARG193 |
| C | CYS215 |
| C | LEU216 |
| C | CYS221 |
| C | VAL242 |
| site_id | AC9 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE FSX C 269 |
| Chain | Residue |
| C | GLU16 |
| C | CYS17 |
| C | THR18 |
| C | GLY19 |
| C | CYS20 |
| C | GLU75 |
| C | THR113 |
| C | CYS114 |
| C | GLY149 |
| C | CYS150 |
| C | PRO151 |
| D | HIS225 |
| site_id | BC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE FNE D 543 |
| Chain | Residue |
| D | CYS71 |
| D | CYS74 |
| D | HIS78 |
| D | VAL467 |
| D | ARG469 |
| D | LEU472 |
| D | VAL490 |
| D | PRO491 |
| D | THR492 |
| D | CYS536 |
| D | CYS539 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE H2S A 904 |
| Chain | Residue |
| A | GLY119 |
| A | ASN255 |
| A | HOH2124 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE H2S C 904 |
| Chain | Residue |
| C | GLY119 |
| C | ASN255 |
| C | HOH2101 |
| C | TYR117 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE H2S D 904 |
| Chain | Residue |
| D | LEU106 |
| D | GLN109 |
| D | PHE110 |
| D | VAL467 |
| D | SER468 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE H2S B 904 |
| Chain | Residue |
| B | LEU106 |
| B | PHE110 |
| B | VAL467 |
| B | SER468 |
Functional Information from PROSITE/UniProt
| site_id | PS00507 |
| Number of Residues | 26 |
| Details | NI_HGENASE_L_1 Nickel-dependent hydrogenases large subunit signature 1. RGIEtilkgrdprdaqhftQRtCGVC |
| Chain | Residue | Details |
| B | ARG49-CYS74 |
| site_id | PS00508 |
| Number of Residues | 10 |
| Details | NI_HGENASE_L_2 Nickel-dependent hydrogenases large subunit signature 2. FDPCIACst.H |
| Chain | Residue | Details |
| B | PHE533-HIS542 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1cc1 |
| Chain | Residue | Details |
| A | THR18 | |
| B | CYS536 | |
| B | GLU24 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1cc1 |
| Chain | Residue | Details |
| C | THR18 | |
| D | CYS536 | |
| D | GLU24 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1cc1 |
| Chain | Residue | Details |
| B | CYS536 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1cc1 |
| Chain | Residue | Details |
| D | CYS536 |
