1E3C

Crystal structure of an Arylsulfatase A mutant C69S soaked in synthetic substrate

Functional Information from GO Data

Chain	GOid	namespace	contents
P	0004065	molecular_function	arylsulfatase activity
P	0004098	molecular_function	cerebroside-sulfatase activity
P	0005509	molecular_function	calcium ion binding
P	0005515	molecular_function	protein binding
P	0005576	cellular_component	extracellular region
P	0005764	cellular_component	lysosome
P	0005783	cellular_component	endoplasmic reticulum
P	0005788	cellular_component	endoplasmic reticulum lumen
P	0006629	biological_process	lipid metabolic process
P	0008484	molecular_function	sulfuric ester hydrolase activity
P	0016787	molecular_function	hydrolase activity
P	0035578	cellular_component	azurophil granule lumen
P	0043202	cellular_component	lysosomal lumen
P	0046872	molecular_function	metal ion binding
P	0070062	cellular_component	extracellular exosome

Functional Information from PROSITE/UniProt

site_id	PS00149
Number of Residues	11
Details	SULFATASE_2 Sulfatases signature 2. GYlTgmAGK.WH

Chain	Residue	Details
P	GLY115-HIS125

---

site_id	PS00523
Number of Residues	13
Details	SULFATASE_1 Sulfatases signature 1. SLSTPSRaaLLTG

Chain	Residue	Details
P	SER67-GLY79

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"7628016","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"evidences":[{"source":"PubMed","id":"12888274","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12888274","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1N2K","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"description":"via 3-oxoalanine","evidences":[{"source":"PubMed","id":"12888274","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1N2K","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11124905","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"3-oxoalanine (Cys)","evidences":[{"source":"PubMed","id":"7628016","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9342345","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12888274","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1N2K","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12888274","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1N2K","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	6
Details	Annotated By Reference To The Literature 1auk

Chain	Residue	Details
P	LYS302
P	HIS229
P	ASP281
P	LYS123
P	SER150
P	HIS125

---

site_id	CSA2
Number of Residues	6
Details	Annotated By Reference To The Literature 1auk

Chain	Residue	Details
P	LYS302
P	HIS229
P	ASP281
P	ARG73
P	LYS123
P	HIS125

---

site_id	MCSA1
Number of Residues	11
Details	M-CSA 158

Chain

Residue

Details

---