1E2T

Arylamine N-acetyltransferase (NAT) from Salmonella typhimurium

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004060	molecular_function	arylamine N-acetyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0016407	molecular_function	acetyltransferase activity
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0046990	molecular_function	N-hydroxyarylamine O-acetyltransferase activity
B	0004060	molecular_function	arylamine N-acetyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0016407	molecular_function	acetyltransferase activity
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0046990	molecular_function	N-hydroxyarylamine O-acetyltransferase activity
C	0004060	molecular_function	arylamine N-acetyltransferase activity
C	0005737	cellular_component	cytoplasm
C	0016407	molecular_function	acetyltransferase activity
C	0016740	molecular_function	transferase activity
C	0016746	molecular_function	acyltransferase activity
C	0046990	molecular_function	N-hydroxyarylamine O-acetyltransferase activity
D	0004060	molecular_function	arylamine N-acetyltransferase activity
D	0005737	cellular_component	cytoplasm
D	0016407	molecular_function	acetyltransferase activity
D	0016740	molecular_function	transferase activity
D	0016746	molecular_function	acyltransferase activity
D	0046990	molecular_function	N-hydroxyarylamine O-acetyltransferase activity
E	0004060	molecular_function	arylamine N-acetyltransferase activity
E	0005737	cellular_component	cytoplasm
E	0016407	molecular_function	acetyltransferase activity
E	0016740	molecular_function	transferase activity
E	0016746	molecular_function	acyltransferase activity
E	0046990	molecular_function	N-hydroxyarylamine O-acetyltransferase activity
F	0004060	molecular_function	arylamine N-acetyltransferase activity
F	0005737	cellular_component	cytoplasm
F	0016407	molecular_function	acetyltransferase activity
F	0016740	molecular_function	transferase activity
F	0016746	molecular_function	acyltransferase activity
F	0046990	molecular_function	N-hydroxyarylamine O-acetyltransferase activity
G	0004060	molecular_function	arylamine N-acetyltransferase activity
G	0005737	cellular_component	cytoplasm
G	0016407	molecular_function	acetyltransferase activity
G	0016740	molecular_function	transferase activity
G	0016746	molecular_function	acyltransferase activity
G	0046990	molecular_function	N-hydroxyarylamine O-acetyltransferase activity
H	0004060	molecular_function	arylamine N-acetyltransferase activity
H	0005737	cellular_component	cytoplasm
H	0016407	molecular_function	acetyltransferase activity
H	0016740	molecular_function	transferase activity
H	0016746	molecular_function	acyltransferase activity
H	0046990	molecular_function	N-hydroxyarylamine O-acetyltransferase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Active site: {"description":"Acyl-thioester intermediate","evidences":[{"source":"PubMed","id":"10876241","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"1569093","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"7889864","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	16
Details	Active site: {"evidences":[{"source":"PubMed","id":"10876241","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	a catalytic site defined by CSA, PubMed 10876241, 2897358

Chain	Residue	Details
A	GLU39
A	CYS69
A	ARG64

---

site_id	MCSA1
Number of Residues	5
Details	M-CSA 515

Chain	Residue	Details
A	GLU39	electrostatic stabiliser
A	ARG64	electrostatic stabiliser
A	CYS69	covalent catalysis, electrostatic stabiliser, proton shuttle (general acid/base)
A	HIS107	modifies pKa, proton shuttle (general acid/base)
A	ASP122	modifies pKa

---

site_id	MCSA2
Number of Residues	5
Details	M-CSA 515

Chain	Residue	Details
B	GLU39	electrostatic stabiliser
B	ARG64	electrostatic stabiliser
B	CYS69	covalent catalysis, electrostatic stabiliser, proton shuttle (general acid/base)
B	HIS107	modifies pKa, proton shuttle (general acid/base)
B	ASP122	modifies pKa

---

site_id	MCSA3
Number of Residues	5
Details	M-CSA 515

Chain	Residue	Details
C	GLU39	electrostatic stabiliser
C	ARG64	electrostatic stabiliser
C	CYS69	covalent catalysis, electrostatic stabiliser, proton shuttle (general acid/base)
C	HIS107	modifies pKa, proton shuttle (general acid/base)
C	ASP122	modifies pKa

---

site_id	MCSA4
Number of Residues	5
Details	M-CSA 515

Chain	Residue	Details
D	GLU39	electrostatic stabiliser
D	ARG64	electrostatic stabiliser
D	CYS69	covalent catalysis, electrostatic stabiliser, proton shuttle (general acid/base)
D	HIS107	modifies pKa, proton shuttle (general acid/base)
D	ASP122	modifies pKa

---

site_id	MCSA5
Number of Residues	5
Details	M-CSA 515

Chain	Residue	Details
E	GLU39	electrostatic stabiliser
E	ARG64	electrostatic stabiliser
E	CYS69	covalent catalysis, electrostatic stabiliser, proton shuttle (general acid/base)
E	HIS107	modifies pKa, proton shuttle (general acid/base)
E	ASP122	modifies pKa

---

site_id	MCSA6
Number of Residues	5
Details	M-CSA 515

Chain	Residue	Details
F	GLU39	electrostatic stabiliser
F	ARG64	electrostatic stabiliser
F	CYS69	covalent catalysis, electrostatic stabiliser, proton shuttle (general acid/base)
F	HIS107	modifies pKa, proton shuttle (general acid/base)
F	ASP122	modifies pKa

---

site_id	MCSA7
Number of Residues	5
Details	M-CSA 515

Chain	Residue	Details
G	GLU39	electrostatic stabiliser
G	ARG64	electrostatic stabiliser
G	CYS69	covalent catalysis, electrostatic stabiliser, proton shuttle (general acid/base)
G	HIS107	modifies pKa, proton shuttle (general acid/base)
G	ASP122	modifies pKa

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site_id	MCSA8
Number of Residues	5
Details	M-CSA 515

Chain	Residue	Details
H	GLU39	electrostatic stabiliser
H	ARG64	electrostatic stabiliser
H	CYS69	covalent catalysis, electrostatic stabiliser, proton shuttle (general acid/base)
H	HIS107	modifies pKa, proton shuttle (general acid/base)
H	ASP122	modifies pKa

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