1E1H

Crystal Structure of recombinant Botulinum Neurotoxin Type A Light Chain, self-inhibiting Zn endopeptidase.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0006508	biological_process	proteolysis
A	0008270	molecular_function	zinc ion binding
B	0004222	molecular_function	metalloendopeptidase activity
B	0006508	biological_process	proteolysis
B	0008270	molecular_function	zinc ion binding
C	0004222	molecular_function	metalloendopeptidase activity
C	0006508	biological_process	proteolysis
C	0008270	molecular_function	zinc ion binding
D	0004222	molecular_function	metalloendopeptidase activity
D	0006508	biological_process	proteolysis
D	0008270	molecular_function	zinc ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 501

Chain	Residue
A	HIS222
A	HIS226
B	GLU261
C	TYR249

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 502

Chain	Residue
A	TYR249
C	HIS222
C	HIS226
D	GLU261

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:15107500, ECO:0000269|PubMed:16846233, ECO:0007744|PDB:2G7P, ECO:0007744|PDB:2G7Q

Chain	Residue	Details
B	GLU261
D	GLU261

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site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: Transition state stabilizer => ECO:0000305|PubMed:16846233

Chain	Residue	Details
B	TYR365
D	TYR365
C	HIS222
C	HIS226

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1i1e

Chain	Residue	Details
B	ARG362
B	GLU261
B	TYR365

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site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1i1e

Chain	Residue	Details
D	ARG362
D	GLU261
D	TYR365

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