Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000287 | molecular_function | magnesium ion binding |
A | 0003824 | molecular_function | catalytic activity |
A | 0004743 | molecular_function | pyruvate kinase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005524 | molecular_function | ATP binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006096 | biological_process | glycolytic process |
A | 0009408 | biological_process | response to heat |
A | 0016020 | cellular_component | membrane |
A | 0016301 | molecular_function | kinase activity |
A | 0016310 | biological_process | phosphorylation |
A | 0030955 | molecular_function | potassium ion binding |
A | 0042802 | molecular_function | identical protein binding |
A | 0046872 | molecular_function | metal ion binding |
A | 1902912 | cellular_component | pyruvate kinase complex |
B | 0000287 | molecular_function | magnesium ion binding |
B | 0003824 | molecular_function | catalytic activity |
B | 0004743 | molecular_function | pyruvate kinase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005524 | molecular_function | ATP binding |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0006096 | biological_process | glycolytic process |
B | 0009408 | biological_process | response to heat |
B | 0016020 | cellular_component | membrane |
B | 0016301 | molecular_function | kinase activity |
B | 0016310 | biological_process | phosphorylation |
B | 0030955 | molecular_function | potassium ion binding |
B | 0042802 | molecular_function | identical protein binding |
B | 0046872 | molecular_function | metal ion binding |
B | 1902912 | cellular_component | pyruvate kinase complex |
C | 0000287 | molecular_function | magnesium ion binding |
C | 0003824 | molecular_function | catalytic activity |
C | 0004743 | molecular_function | pyruvate kinase activity |
C | 0005515 | molecular_function | protein binding |
C | 0005524 | molecular_function | ATP binding |
C | 0005737 | cellular_component | cytoplasm |
C | 0005829 | cellular_component | cytosol |
C | 0006096 | biological_process | glycolytic process |
C | 0009408 | biological_process | response to heat |
C | 0016020 | cellular_component | membrane |
C | 0016301 | molecular_function | kinase activity |
C | 0016310 | biological_process | phosphorylation |
C | 0030955 | molecular_function | potassium ion binding |
C | 0042802 | molecular_function | identical protein binding |
C | 0046872 | molecular_function | metal ion binding |
C | 1902912 | cellular_component | pyruvate kinase complex |
D | 0000287 | molecular_function | magnesium ion binding |
D | 0003824 | molecular_function | catalytic activity |
D | 0004743 | molecular_function | pyruvate kinase activity |
D | 0005515 | molecular_function | protein binding |
D | 0005524 | molecular_function | ATP binding |
D | 0005737 | cellular_component | cytoplasm |
D | 0005829 | cellular_component | cytosol |
D | 0006096 | biological_process | glycolytic process |
D | 0009408 | biological_process | response to heat |
D | 0016020 | cellular_component | membrane |
D | 0016301 | molecular_function | kinase activity |
D | 0016310 | biological_process | phosphorylation |
D | 0030955 | molecular_function | potassium ion binding |
D | 0042802 | molecular_function | identical protein binding |
D | 0046872 | molecular_function | metal ion binding |
D | 1902912 | cellular_component | pyruvate kinase complex |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE SO4 A 701 |
Chain | Residue |
A | THR378 |
A | GLN379 |
A | GLY380 |
A | GLY381 |
A | LYS382 |
A | SER383 |
A | GLY460 |
site_id | AC2 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE SO4 B 702 |
Chain | Residue |
B | GLY380 |
B | GLY381 |
B | LYS382 |
B | SER383 |
B | SER459 |
B | GLY460 |
B | THR378 |
B | GLN379 |
site_id | AC3 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE SO4 C 703 |
Chain | Residue |
C | THR378 |
C | GLN379 |
C | GLY380 |
C | GLY381 |
C | LYS382 |
C | SER459 |
C | GLY460 |
site_id | AC4 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE SO4 D 704 |
Chain | Residue |
D | THR378 |
D | GLN379 |
D | GLY380 |
D | GLY381 |
D | LYS382 |
D | SER383 |
D | SER459 |
D | GLY460 |
D | THR461 |
Functional Information from PROSITE/UniProt
site_id | PS00110 |
Number of Residues | 13 |
Details | PYRUVATE_KINASE Pyruvate kinase active site signature. IhIISKIENqEGL |
Chain | Residue | Details |
A | ILE215-LEU227 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | ARG32 | |
A | THR278 | |
B | ARG32 | |
B | ASN34 | |
B | SER36 | |
B | ASP66 | |
B | THR67 | |
B | LYS220 | |
B | GLU222 | |
B | GLY245 | |
B | ASP246 | |
A | ASN34 | |
B | THR278 | |
C | ARG32 | |
C | ASN34 | |
C | SER36 | |
C | ASP66 | |
C | THR67 | |
C | LYS220 | |
C | GLU222 | |
C | GLY245 | |
C | ASP246 | |
A | SER36 | |
C | THR278 | |
D | ARG32 | |
D | ASN34 | |
D | SER36 | |
D | ASP66 | |
D | THR67 | |
D | LYS220 | |
D | GLU222 | |
D | GLY245 | |
D | ASP246 | |
A | ASP66 | |
D | THR278 | |
A | THR67 | |
A | LYS220 | |
A | GLU222 | |
A | GLY245 | |
A | ASP246 | |
Chain | Residue | Details |
A | ARG73 | |
A | LYS156 | |
B | ARG73 | |
B | LYS156 | |
C | ARG73 | |
C | LYS156 | |
D | ARG73 | |
D | LYS156 | |
Chain | Residue | Details |
A | LYS220 | |
B | LYS220 | |
C | LYS220 | |
D | LYS220 | |
Chain | Residue | Details |
A | LYS76 | |
A | LYS319 | |
B | LYS76 | |
B | LYS319 | |
C | LYS76 | |
C | LYS319 | |
D | LYS76 | |
D | LYS319 | |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 6 |
Details | Annotated By Reference To The Literature 1pkn |
Chain | Residue | Details |
A | THR278 | |
A | GLU314 | |
A | LYS220 | |
A | ARG32 | |
A | ARG73 | |
A | SER312 | |
site_id | CSA2 |
Number of Residues | 6 |
Details | Annotated By Reference To The Literature 1pkn |
Chain | Residue | Details |
B | THR278 | |
B | GLU314 | |
B | LYS220 | |
B | ARG32 | |
B | ARG73 | |
B | SER312 | |
site_id | CSA3 |
Number of Residues | 6 |
Details | Annotated By Reference To The Literature 1pkn |
Chain | Residue | Details |
C | THR278 | |
C | GLU314 | |
C | LYS220 | |
C | ARG32 | |
C | ARG73 | |
C | SER312 | |
site_id | CSA4 |
Number of Residues | 6 |
Details | Annotated By Reference To The Literature 1pkn |
Chain | Residue | Details |
D | THR278 | |
D | GLU314 | |
D | LYS220 | |
D | ARG32 | |
D | ARG73 | |
D | SER312 | |