Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004146 | molecular_function | dihydrofolate reductase activity |
A | 0005739 | cellular_component | mitochondrion |
A | 0006730 | biological_process | one-carbon metabolic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0046452 | biological_process | dihydrofolate metabolic process |
A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
A | 0046655 | biological_process | folic acid metabolic process |
A | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 28 |
Details | BINDING SITE FOR RESIDUE NDP A 391 |
Chain | Residue |
A | VAL11 |
A | ALA12 |
A | ILE19 |
A | ASN23 |
A | SER24 |
A | LEU25 |
A | GLY58 |
A | ARG59 |
A | LYS60 |
A | THR61 |
A | ILE80 |
A | THR81 |
A | ARG82 |
A | ASN83 |
A | LYS96 |
A | ILE123 |
A | GLY125 |
A | ALA126 |
A | GLN127 |
A | LEU128 |
A | TYR129 |
A | ALA131 |
A | TOP407 |
A | HOH542 |
A | HOH567 |
A | HOH589 |
A | HOH594 |
A | HOH699 |
site_id | AC2 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE TOP A 407 |
Chain | Residue |
A | ILE10 |
A | VAL11 |
A | LEU25 |
A | GLU32 |
A | PHE36 |
A | PRO66 |
A | ILE123 |
A | TYR129 |
A | NDP391 |
A | HOH525 |
site_id | S1 |
Number of Residues | 11 |
Details | |
Chain | Residue |
A | ILE10 |
A | TYR129 |
A | THR144 |
A | LEU25 |
A | TRP27 |
A | GLU32 |
A | ILE33 |
A | PHE36 |
A | ILE65 |
A | PRO66 |
A | ILE123 |
Functional Information from PROSITE/UniProt
site_id | PS00075 |
Number of Residues | 23 |
Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. GIGrsnsLPWklkk.EisyFkrvT |
Chain | Residue | Details |
A | GLY18-THR40 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | ALA12 | |
A | GLY18 | |
A | ARG59 | |
A | THR81 | |
A | GLY124 | |
Chain | Residue | Details |
A | GLU32 | |
A | ARG75 | |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1dhf |
Chain | Residue | Details |
A | LEU25 | |
A | GLU32 | |