1DXL
Dihydrolipoamide dehydrogenase of glycine decarboxylase from Pisum Sativum
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004148 | molecular_function | dihydrolipoyl dehydrogenase (NADH) activity |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0005960 | cellular_component | glycine cleavage complex |
| A | 0006103 | biological_process | 2-oxoglutarate metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
| A | 0019464 | biological_process | glycine decarboxylation via glycine cleavage system |
| A | 0045252 | cellular_component | oxoglutarate dehydrogenase complex |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| B | 0004148 | molecular_function | dihydrolipoyl dehydrogenase (NADH) activity |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005759 | cellular_component | mitochondrial matrix |
| B | 0005960 | cellular_component | glycine cleavage complex |
| B | 0006103 | biological_process | 2-oxoglutarate metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
| B | 0019464 | biological_process | glycine decarboxylation via glycine cleavage system |
| B | 0045252 | cellular_component | oxoglutarate dehydrogenase complex |
| B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| C | 0004148 | molecular_function | dihydrolipoyl dehydrogenase (NADH) activity |
| C | 0005739 | cellular_component | mitochondrion |
| C | 0005759 | cellular_component | mitochondrial matrix |
| C | 0005960 | cellular_component | glycine cleavage complex |
| C | 0006103 | biological_process | 2-oxoglutarate metabolic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
| C | 0019464 | biological_process | glycine decarboxylation via glycine cleavage system |
| C | 0045252 | cellular_component | oxoglutarate dehydrogenase complex |
| C | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| D | 0004148 | molecular_function | dihydrolipoyl dehydrogenase (NADH) activity |
| D | 0005739 | cellular_component | mitochondrion |
| D | 0005759 | cellular_component | mitochondrial matrix |
| D | 0005960 | cellular_component | glycine cleavage complex |
| D | 0006103 | biological_process | 2-oxoglutarate metabolic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
| D | 0019464 | biological_process | glycine decarboxylation via glycine cleavage system |
| D | 0045252 | cellular_component | oxoglutarate dehydrogenase complex |
| D | 0050660 | molecular_function | flavin adenine dinucleotide binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 33 |
| Details | BINDING SITE FOR RESIDUE FAD A 480 |
| Chain | Residue |
| A | ILE12 |
| A | CYS45 |
| A | VAL48 |
| A | GLY49 |
| A | CYS50 |
| A | LYS54 |
| A | GLY116 |
| A | TYR117 |
| A | GLY118 |
| A | ALA146 |
| A | THR147 |
| A | GLY15 |
| A | GLY148 |
| A | SER149 |
| A | SER167 |
| A | TYR187 |
| A | ILE188 |
| A | ARG277 |
| A | ASP317 |
| A | MET323 |
| A | LEU324 |
| A | ALA325 |
| A | PRO16 |
| A | HIS326 |
| A | ALA328 |
| A | TYR356 |
| B | HIS449 |
| A | GLY17 |
| A | GLU36 |
| A | LYS37 |
| A | ARG38 |
| A | GLY43 |
| A | THR44 |
| site_id | AC2 |
| Number of Residues | 32 |
| Details | BINDING SITE FOR RESIDUE FAD B 480 |
| Chain | Residue |
| A | HIS449 |
| B | ILE12 |
| B | GLY15 |
| B | PRO16 |
| B | GLY17 |
| B | ILE35 |
| B | GLU36 |
| B | LYS37 |
| B | ARG38 |
| B | GLY43 |
| B | THR44 |
| B | CYS45 |
| B | GLY49 |
| B | CYS50 |
| B | LYS54 |
| B | GLY116 |
| B | TYR117 |
| B | GLY118 |
| B | ALA146 |
| B | THR147 |
| B | GLY148 |
| B | SER149 |
| B | ILE188 |
| B | ARG277 |
| B | LEU284 |
| B | ASP317 |
| B | MET323 |
| B | LEU324 |
| B | ALA325 |
| B | HIS326 |
| B | ALA328 |
| B | HOH2006 |
| site_id | AC3 |
| Number of Residues | 33 |
| Details | BINDING SITE FOR RESIDUE FAD C 480 |
| Chain | Residue |
| C | ILE12 |
| C | GLY13 |
| C | GLY14 |
| C | GLY15 |
| C | PRO16 |
| C | GLY17 |
| C | GLU36 |
| C | LYS37 |
| C | ARG38 |
| C | GLY43 |
| C | THR44 |
| C | CYS45 |
| C | VAL48 |
| C | GLY49 |
| C | LYS54 |
| C | GLY116 |
| C | TYR117 |
| C | GLY118 |
| C | ALA146 |
| C | THR147 |
| C | GLY148 |
| C | ILE188 |
| C | ARG277 |
| C | PHE280 |
| C | ASP317 |
| C | MET323 |
| C | LEU324 |
| C | ALA325 |
| C | HIS326 |
| C | ALA328 |
| C | TYR356 |
| C | HOH2001 |
| D | HIS449 |
| site_id | AC4 |
| Number of Residues | 32 |
| Details | BINDING SITE FOR RESIDUE FAD D 480 |
| Chain | Residue |
| D | ILE12 |
| D | GLY14 |
| D | GLY15 |
| D | PRO16 |
| D | GLY17 |
| D | ILE35 |
| D | GLU36 |
| D | LYS37 |
| D | ARG38 |
| D | GLY43 |
| D | THR44 |
| D | CYS45 |
| D | GLY49 |
| D | CYS50 |
| D | LYS54 |
| D | GLY116 |
| D | TYR117 |
| D | GLY118 |
| D | ALA146 |
| D | THR147 |
| D | GLY148 |
| D | SER149 |
| D | ILE188 |
| D | ARG277 |
| D | ASP317 |
| D | MET323 |
| D | LEU324 |
| D | ALA325 |
| D | HIS326 |
| D | ALA328 |
| D | TYR356 |
| C | HIS449 |
Functional Information from PROSITE/UniProt
| site_id | PS00076 |
| Number of Residues | 11 |
| Details | PYRIDINE_REDOX_1 Pyridine nucleotide-disulphide oxidoreductases class-I active site. GGtCLnvGCIP |
| Chain | Residue | Details |
| A | GLY42-PRO52 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 56 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10806386","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 52 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1get |
| Chain | Residue | Details |
| A | GLU454 | |
| A | HIS449 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1get |
| Chain | Residue | Details |
| B | GLU454 | |
| B | HIS449 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1get |
| Chain | Residue | Details |
| C | GLU454 | |
| C | HIS449 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1get |
| Chain | Residue | Details |
| D | GLU454 | |
| D | HIS449 |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1get |
| Chain | Residue | Details |
| A | CYS45 | |
| A | CYS50 |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1get |
| Chain | Residue | Details |
| B | CYS45 | |
| B | CYS50 |
| site_id | CSA7 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1get |
| Chain | Residue | Details |
| C | CYS45 | |
| C | CYS50 |
| site_id | CSA8 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1get |
| Chain | Residue | Details |
| D | CYS45 | |
| D | CYS50 |
