1DWV

MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DIMER N-hydroxyarginine and 4-amino tetrahydrobiopterin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004517	molecular_function	nitric-oxide synthase activity
A	0006809	biological_process	nitric oxide biosynthetic process
A	0020037	molecular_function	heme binding
B	0004517	molecular_function	nitric-oxide synthase activity
B	0006809	biological_process	nitric oxide biosynthetic process
B	0020037	molecular_function	heme binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 903

Chain	Residue
A	CYS104
A	CYS104
A	CYS109
A	CYS109

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 904

Chain	Residue
A	ARG80
A	HIS91
A	HOH2207

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 905

Chain	Residue
A	LYS82
A	ILE89

---

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 A 906

Chain	Residue
A	LEU177

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 907

Chain	Residue
A	LYS97
A	GLN143
A	ARG448

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 903

Chain	Residue
B	CYS104
B	CYS104
B	CYS109
B	CYS109

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 904

Chain	Residue
B	THR176
B	LEU177
B	HOH2214
B	HOH2215

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 905

Chain	Residue
B	LEU94
B	LYS97
B	GLN143
B	ARG448
B	HOH2216

---

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 906

Chain	Residue
B	ARG80
B	LYS82
B	ILE89

---

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 907

Chain	Residue
B	ARG80
B	ILE89
B	HIS91

---

site_id	BC2
Number of Residues	19
Details	BINDING SITE FOR RESIDUE HEM A 901

Chain	Residue
A	TRP188
A	ARG193
A	CYS194
A	SER236
A	PHE363
A	ASN364
A	GLY365
A	TRP366
A	GLU371
A	TRP457
A	TYR485
A	4AB902
A	HAR909
A	HOH2198
A	HOH2199
A	HOH2200
A	HOH2201
A	HOH2202
A	HOH2203

---

site_id	BC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 4AB A 902

Chain	Residue
A	SER112
A	ARG375
A	TRP455
A	ILE456
A	TRP457
A	PHE470
A	HIS471
A	HEM901
A	HOH2178
A	HOH2203
A	HOH2205
A	HOH2206

---

site_id	BC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE HAR A 909

Chain	Residue
A	GLN257
A	TYR341
A	PRO344
A	GLY365
A	TRP366
A	TYR367
A	GLU371
A	ASP376
A	HEM901
A	HOH2208
A	HOH2209

---

site_id	BC5
Number of Residues	19
Details	BINDING SITE FOR RESIDUE HEM B 901

Chain	Residue
B	TRP188
B	ARG193
B	CYS194
B	SER236
B	PHE363
B	ASN364
B	GLY365
B	TRP366
B	GLU371
B	TRP457
B	TYR485
B	4AB902
B	HAR909
B	HOH2205
B	HOH2206
B	HOH2207
B	HOH2208
B	HOH2209
B	HOH2210

---

site_id	BC6
Number of Residues	13
Details	BINDING SITE FOR RESIDUE 4AB B 902

Chain	Residue
B	HIS471
B	GLU473
B	HEM901
B	HOH2183
B	HOH2209
B	HOH2211
B	HOH2213
B	SER112
B	ARG375
B	TRP455
B	ILE456
B	TRP457
B	PHE470

---

site_id	BC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE HAR B 909

Chain	Residue
B	GLN257
B	TYR341
B	PRO344
B	GLY365
B	TRP366
B	TYR367
B	GLU371
B	ASP376
B	HEM901
B	HOH2152

---

Functional Information from PROSITE/UniProt

site_id	PS60001
Number of Residues	8
Details	NOS Nitric oxide synthase (NOS) signature. RCIGRIqW

Chain	Residue	Details
A	ARG193-TRP200

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10562539","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10769116","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12464241","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1DF1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1DWV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1DWW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1N2N","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10562539","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10769116","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11669619","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12437348","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12464241","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9516116","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1DF1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1DWX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1JWJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M8D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M8E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M8H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M8I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M9T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1N2N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NOD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QOM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2NOD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NOD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"10562539","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10769116","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11669619","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12437348","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12464241","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9334294","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9516116","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1DF1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1DWV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1DWW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1DWX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1JWJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1JWK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M8D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M8E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M8H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M8I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M9T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1N2N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NOC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NOD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NOS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QOM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2NOD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2NOS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NOD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P29474","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10562539","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10769116","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11669619","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12437348","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12464241","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9516116","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1DF1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1DWX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1JWJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1JWK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M8D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M8E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M8H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M8I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M9T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1N2N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NOD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QOM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NOD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10562539","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12437348","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12464241","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1DF1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M9T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1N2N","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10562539","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10769116","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12437348","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12464241","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9516116","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1DF1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1DWX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M8D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M8E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M8I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M9T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1N2N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NOD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QOM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2NOD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NOD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10562539","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10769116","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11669619","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12437348","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12464241","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9516116","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1DF1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1DWX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1JWJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1JWK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M8D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M8E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M8H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M8I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1N2N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NOD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QOM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2NOD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NOD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10562539","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10769116","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9516116","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1DF1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1DWX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NOD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QOM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2NOD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NOD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 3nos

Chain	Residue	Details
A	TRP366
A	ARG197
A	CYS194
A	GLU371

---

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 3nos

Chain	Residue	Details
B	TRP366
B	ARG197
B	CYS194
B	GLU371

---