Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1DWV

MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DIMER N-hydroxyarginine and 4-amino tetrahydrobiopterin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004517	molecular_function	nitric-oxide synthase activity
A	0006809	biological_process	nitric oxide biosynthetic process
A	0020037	molecular_function	heme binding
B	0004517	molecular_function	nitric-oxide synthase activity
B	0006809	biological_process	nitric oxide biosynthetic process
B	0020037	molecular_function	heme binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 903

Chain	Residue
A	CYS104
A	CYS104
A	CYS109
A	CYS109

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 904

Chain	Residue
A	ARG80
A	HIS91
A	HOH2207

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 905

Chain	Residue
A	LYS82
A	ILE89

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 A 906

Chain	Residue
A	LEU177

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 907

Chain	Residue
A	LYS97
A	GLN143
A	ARG448

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 903

Chain	Residue
B	CYS104
B	CYS104
B	CYS109
B	CYS109

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 904

Chain	Residue
B	THR176
B	LEU177
B	HOH2214
B	HOH2215

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 905

Chain	Residue
B	LEU94
B	LYS97
B	GLN143
B	ARG448
B	HOH2216

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 906

Chain	Residue
B	ARG80
B	LYS82
B	ILE89

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 907

Chain	Residue
B	ARG80
B	ILE89
B	HIS91

site_id	BC2
Number of Residues	19
Details	BINDING SITE FOR RESIDUE HEM A 901

Chain	Residue
A	TRP188
A	ARG193
A	CYS194
A	SER236
A	PHE363
A	ASN364
A	GLY365
A	TRP366
A	GLU371
A	TRP457
A	TYR485
A	4AB902
A	HAR909
A	HOH2198
A	HOH2199
A	HOH2200
A	HOH2201
A	HOH2202
A	HOH2203

site_id	BC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 4AB A 902

Chain	Residue
A	SER112
A	ARG375
A	TRP455
A	ILE456
A	TRP457
A	PHE470
A	HIS471
A	HEM901
A	HOH2178
A	HOH2203
A	HOH2205
A	HOH2206

site_id	BC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE HAR A 909

Chain	Residue
A	GLN257
A	TYR341
A	PRO344
A	GLY365
A	TRP366
A	TYR367
A	GLU371
A	ASP376
A	HEM901
A	HOH2208
A	HOH2209

site_id	BC5
Number of Residues	19
Details	BINDING SITE FOR RESIDUE HEM B 901

Chain	Residue
B	TRP188
B	ARG193
B	CYS194
B	SER236
B	PHE363
B	ASN364
B	GLY365
B	TRP366
B	GLU371
B	TRP457
B	TYR485
B	4AB902
B	HAR909
B	HOH2205
B	HOH2206
B	HOH2207
B	HOH2208
B	HOH2209
B	HOH2210

site_id	BC6
Number of Residues	13
Details	BINDING SITE FOR RESIDUE 4AB B 902

Chain	Residue
B	HIS471
B	GLU473
B	HEM901
B	HOH2183
B	HOH2209
B	HOH2211
B	HOH2213
B	SER112
B	ARG375
B	TRP455
B	ILE456
B	TRP457
B	PHE470

site_id	BC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE HAR B 909

Chain	Residue
B	GLN257
B	TYR341
B	PRO344
B	GLY365
B	TRP366
B	TYR367
B	GLU371
B	ASP376
B	HEM901
B	HOH2152

Functional Information from PROSITE/UniProt

site_id	PS60001
Number of Residues	8
Details	NOS Nitric oxide synthase (NOS) signature. RCIGRIqW

Chain	Residue	Details
A	ARG193-TRP200

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:10562539, ECO:0000269\|PubMed:10769116, ECO:0000269\|PubMed:12464241, ECO:0007744\|PDB:1DF1, ECO:0007744\|PDB:1DWV, ECO:0007744\|PDB:1DWW, ECO:0007744\|PDB:1N2N

Chain	Residue	Details
A	CYS104
A	CYS109
B	CYS104
B	CYS109

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:10562539, ECO:0000269\|PubMed:10769116, ECO:0000269\|PubMed:11669619, ECO:0000269\|PubMed:12437348, ECO:0000269\|PubMed:12464241, ECO:0000269\|PubMed:9516116, ECO:0007744\|PDB:1DF1, ECO:0007744\|PDB:1DWX, ECO:0007744\|PDB:1JWJ, ECO:0007744\|PDB:1M8D, ECO:0007744\|PDB:1M8E, ECO:0007744\|PDB:1M8H, ECO:0007744\|PDB:1M8I, ECO:0007744\|PDB:1M9T, ECO:0007744\|PDB:1N2N, ECO:0007744\|PDB:1NOD, ECO:0007744\|PDB:1QOM, ECO:0007744\|PDB:2NOD, ECO:0007744\|PDB:3NOD

Chain	Residue	Details
A	SER112
B	SER112

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: axial binding residue => ECO:0000269\|PubMed:10562539, ECO:0000269\|PubMed:10769116, ECO:0000269\|PubMed:11669619, ECO:0000269\|PubMed:12437348, ECO:0000269\|PubMed:12464241, ECO:0000269\|PubMed:9334294, ECO:0000269\|PubMed:9516116, ECO:0007744\|PDB:1DF1, ECO:0007744\|PDB:1DWV, ECO:0007744\|PDB:1DWW, ECO:0007744\|PDB:1DWX, ECO:0007744\|PDB:1JWJ, ECO:0007744\|PDB:1JWK, ECO:0007744\|PDB:1M8D, ECO:0007744\|PDB:1M8E, ECO:0007744\|PDB:1M8H, ECO:0007744\|PDB:1M8I, ECO:0007744\|PDB:1M9T, ECO:0007744\|PDB:1N2N, ECO:0007744\|PDB:1NOC, ECO:0007744\|PDB:1NOD, ECO:0007744\|PDB:1NOS, ECO:0007744\|PDB:1QOM, ECO:0007744\|PDB:2NOD, ECO:0007744\|PDB:2NOS, ECO:0007744\|PDB:3NOD

Chain	Residue	Details
A	CYS194
B	CYS194

site_id	SWS_FT_FI4
Number of Residues	8
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P29474

Chain	Residue	Details
A	GLN257
A	TRP366
A	TYR367
A	GLU371
B	GLN257
B	TRP366
B	TYR367
B	GLU371

site_id	SWS_FT_FI5
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:10562539, ECO:0000269\|PubMed:10769116, ECO:0000269\|PubMed:11669619, ECO:0000269\|PubMed:12437348, ECO:0000269\|PubMed:12464241, ECO:0000269\|PubMed:9516116, ECO:0007744\|PDB:1DF1, ECO:0007744\|PDB:1DWX, ECO:0007744\|PDB:1JWJ, ECO:0007744\|PDB:1JWK, ECO:0007744\|PDB:1M8D, ECO:0007744\|PDB:1M8E, ECO:0007744\|PDB:1M8H, ECO:0007744\|PDB:1M8I, ECO:0007744\|PDB:1M9T, ECO:0007744\|PDB:1N2N, ECO:0007744\|PDB:1NOD, ECO:0007744\|PDB:1QOM, ECO:0007744\|PDB:3NOD

Chain	Residue	Details
A	ARG375
B	ARG375

site_id	SWS_FT_FI6
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:10562539, ECO:0000269\|PubMed:12437348, ECO:0000269\|PubMed:12464241, ECO:0007744\|PDB:1DF1, ECO:0007744\|PDB:1M9T, ECO:0007744\|PDB:1N2N

Chain	Residue	Details
A	ILE456
B	ILE456

site_id	SWS_FT_FI7
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:10562539, ECO:0000269\|PubMed:10769116, ECO:0000269\|PubMed:12437348, ECO:0000269\|PubMed:12464241, ECO:0000269\|PubMed:9516116, ECO:0007744\|PDB:1DF1, ECO:0007744\|PDB:1DWX, ECO:0007744\|PDB:1M8D, ECO:0007744\|PDB:1M8E, ECO:0007744\|PDB:1M8I, ECO:0007744\|PDB:1M9T, ECO:0007744\|PDB:1N2N, ECO:0007744\|PDB:1NOD, ECO:0007744\|PDB:1QOM, ECO:0007744\|PDB:2NOD, ECO:0007744\|PDB:3NOD

Chain	Residue	Details
A	TRP457
B	TRP457

site_id	SWS_FT_FI8
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:10562539, ECO:0000269\|PubMed:10769116, ECO:0000269\|PubMed:11669619, ECO:0000269\|PubMed:12437348, ECO:0000269\|PubMed:12464241, ECO:0000269\|PubMed:9516116, ECO:0007744\|PDB:1DF1, ECO:0007744\|PDB:1DWX, ECO:0007744\|PDB:1JWJ, ECO:0007744\|PDB:1JWK, ECO:0007744\|PDB:1M8D, ECO:0007744\|PDB:1M8E, ECO:0007744\|PDB:1M8H, ECO:0007744\|PDB:1M8I, ECO:0007744\|PDB:1N2N, ECO:0007744\|PDB:1NOD, ECO:0007744\|PDB:1QOM, ECO:0007744\|PDB:2NOD, ECO:0007744\|PDB:3NOD

Chain	Residue	Details
A	PHE470
B	PHE470

site_id	SWS_FT_FI9
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:10562539, ECO:0000269\|PubMed:10769116, ECO:0000269\|PubMed:9516116, ECO:0007744\|PDB:1DF1, ECO:0007744\|PDB:1DWX, ECO:0007744\|PDB:1NOD, ECO:0007744\|PDB:1QOM, ECO:0007744\|PDB:2NOD, ECO:0007744\|PDB:3NOD

Chain	Residue	Details
A	TYR485
B	TYR485

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 3nos

Chain	Residue	Details
A	TRP366
A	ARG197
A	CYS194
A	GLU371

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 3nos

Chain	Residue	Details
B	TRP366
B	ARG197
B	CYS194
B	GLU371

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)