1DT5

THE STRUCTURAL ORIGINS OF INTERFACIAL ACTIVATION IN THERMOMYCES (HUMICOLA) LANUGINOSA LIPASE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004806	molecular_function	triglyceride lipase activity
A	0006629	biological_process	lipid metabolic process
A	0016042	biological_process	lipid catabolic process
A	0016787	molecular_function	hydrolase activity
B	0004806	molecular_function	triglyceride lipase activity
B	0006629	biological_process	lipid metabolic process
B	0016042	biological_process	lipid catabolic process
B	0016787	molecular_function	hydrolase activity
C	0004806	molecular_function	triglyceride lipase activity
C	0006629	biological_process	lipid metabolic process
C	0016042	biological_process	lipid catabolic process
C	0016787	molecular_function	hydrolase activity
D	0004806	molecular_function	triglyceride lipase activity
D	0006629	biological_process	lipid metabolic process
D	0016042	biological_process	lipid catabolic process
D	0016787	molecular_function	hydrolase activity
E	0004806	molecular_function	triglyceride lipase activity
E	0006629	biological_process	lipid metabolic process
E	0016042	biological_process	lipid catabolic process
E	0016787	molecular_function	hydrolase activity
F	0004806	molecular_function	triglyceride lipase activity
F	0006629	biological_process	lipid metabolic process
F	0016042	biological_process	lipid catabolic process
F	0016787	molecular_function	hydrolase activity
G	0004806	molecular_function	triglyceride lipase activity
G	0006629	biological_process	lipid metabolic process
G	0016042	biological_process	lipid catabolic process
G	0016787	molecular_function	hydrolase activity
H	0004806	molecular_function	triglyceride lipase activity
H	0006629	biological_process	lipid metabolic process
H	0016042	biological_process	lipid catabolic process
H	0016787	molecular_function	hydrolase activity

Functional Information from PROSITE/UniProt

site_id	PS00120
Number of Residues	10
Details	LIPASE_SER Lipases, serine active site. VVFTGHSLGG

Chain	Residue	Details
A	VAL140-GLY149

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: Nucleophile => ECO:0000269|PubMed:8014587

Chain	Residue	Details
A	SER146
B	SER146
C	SER146
D	SER146
E	SER146
F	SER146
G	SER146
H	SER146

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	ACT_SITE: Charge relay system => ECO:0000305|PubMed:8014587

Chain	Residue	Details
A	ASP201
E	HIS258
F	ASP201
F	HIS258
G	ASP201
G	HIS258
H	ASP201
H	HIS258
A	HIS258
B	ASP201
B	HIS258
C	ASP201
C	HIS258
D	ASP201
D	HIS258
E	ASP201

---