1DS6
CRYSTAL STRUCTURE OF A RAC-RHOGDI COMPLEX
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0003925 | molecular_function | G protein activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005635 | cellular_component | nuclear envelope |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005741 | cellular_component | mitochondrial outer membrane |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005829 | cellular_component | cytosol |
| A | 0005856 | cellular_component | cytoskeleton |
| A | 0005884 | cellular_component | actin filament |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005925 | cellular_component | focal adhesion |
| A | 0006935 | biological_process | chemotaxis |
| A | 0007015 | biological_process | actin filament organization |
| A | 0007163 | biological_process | establishment or maintenance of cell polarity |
| A | 0007165 | biological_process | signal transduction |
| A | 0007264 | biological_process | small GTPase-mediated signal transduction |
| A | 0008360 | biological_process | regulation of cell shape |
| A | 0010310 | biological_process | regulation of hydrogen peroxide metabolic process |
| A | 0010592 | biological_process | positive regulation of lamellipodium assembly |
| A | 0010810 | biological_process | regulation of cell-substrate adhesion |
| A | 0016020 | cellular_component | membrane |
| A | 0019887 | molecular_function | protein kinase regulator activity |
| A | 0030027 | cellular_component | lamellipodium |
| A | 0030036 | biological_process | actin cytoskeleton organization |
| A | 0030670 | cellular_component | phagocytic vesicle membrane |
| A | 0031410 | cellular_component | cytoplasmic vesicle |
| A | 0042129 | biological_process | regulation of T cell proliferation |
| A | 0042554 | biological_process | superoxide anion generation |
| A | 0043020 | cellular_component | NADPH oxidase complex |
| A | 0043304 | biological_process | regulation of mast cell degranulation |
| A | 0045453 | biological_process | bone resorption |
| A | 0045730 | biological_process | respiratory burst |
| A | 0060263 | biological_process | regulation of respiratory burst |
| A | 0060753 | biological_process | regulation of mast cell chemotaxis |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0071593 | biological_process | lymphocyte aggregation |
| A | 0090023 | biological_process | positive regulation of neutrophil chemotaxis |
| A | 1902622 | biological_process | regulation of neutrophil migration |
| A | 1903749 | biological_process | positive regulation of protein localization to mitochondrion |
| B | 0005094 | molecular_function | Rho GDP-dissociation inhibitor activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0007266 | biological_process | Rho protein signal transduction |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 193 |
| Chain | Residue |
| A | THR17 |
| A | THR35 |
| A | GDP194 |
| A | HOH509 |
| A | HOH539 |
| A | HOH550 |
| site_id | AC2 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE GDP A 194 |
| Chain | Residue |
| A | VAL14 |
| A | GLY15 |
| A | LYS16 |
| A | THR17 |
| A | CYS18 |
| A | PHE28 |
| A | ILE33 |
| A | LYS116 |
| A | ASP118 |
| A | LEU119 |
| A | SER158 |
| A | ALA159 |
| A | LEU160 |
| A | MG193 |
| A | HOH531 |
| A | HOH539 |
| A | HOH547 |
| A | HOH550 |
| A | HOH576 |
| A | HOH592 |
| A | HOH593 |
| A | HOH628 |
| A | ASP11 |
| A | GLY12 |
| A | ALA13 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Motif: {"description":"Effector region","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"ADP-ribosylasparagine; by botulinum toxin","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 7 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230","evidences":[{"source":"PubMed","id":"24141704","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| A | GLN61 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| A | ALA13 |
