1DRU

ESCHERICHIA COLI DHPR/NADH COMPLEX

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0008652	biological_process	amino acid biosynthetic process
A	0008839	molecular_function	4-hydroxy-tetrahydrodipicolinate reductase
A	0009085	biological_process	lysine biosynthetic process
A	0009089	biological_process	lysine biosynthetic process via diaminopimelate
A	0016491	molecular_function	oxidoreductase activity
A	0016726	molecular_function	oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor
A	0019877	biological_process	diaminopimelate biosynthetic process
A	0042802	molecular_function	identical protein binding
A	0050661	molecular_function	NADP binding
A	0051287	molecular_function	NAD binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	BINDING SITE FOR RESIDUE NAD A 301

Chain	Residue
A	GLY12
A	GLY15
A	ARG16
A	MET17
A	GLU38
A	ARG39
A	PHE79
A	THR80
A	ARG81
A	GLY84
A	GLY102
A	THR103
A	THR104
A	ALA126
A	ALA127
A	ASN128
A	PHE129
A	PHE243
A	HOH401

---

site_id	BIN
Number of Residues	15
Details	DINUCLEOTIDE BINDING SITE

Chain	Residue
A	GLY12
A	GLY102
A	THR104
A	ALA126
A	ALA127
A	PHE129
A	ARG240
A	GLY15
A	ARG16
A	MET17
A	GLU38
A	ARG39
A	THR80
A	ARG81
A	GLY84

---

Functional Information from PROSITE/UniProt

site_id	PS01298
Number of Residues	18
Details	DAPB Dihydrodipicolinate reductase signature. EIiEaHhrhKvDapSGTA

Chain	Residue	Details
A	GLU154-ALA171

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor

Chain	Residue	Details
A	HIS159

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton donor

Chain	Residue	Details
A	LYS163

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:7893645, ECO:0007744|PDB:1DIH

Chain	Residue	Details
A	ARG16
A	ARG39
A	GLY102
A	PHE129
A	ARG240
A	GLY12

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:8873595, ECO:0000269|PubMed:9398235, ECO:0007744|PDB:1ARZ, ECO:0007744|PDB:1DRU

Chain	Residue	Details
A	GLU38
A	THR80
A	ALA126
A	GLY15

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	BINDING:

Chain	Residue	Details
A	GLY169
A	HIS160

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:9398235, ECO:0007744|PDB:1ARZ

Chain	Residue	Details
A	PHE243
A	LYS163

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	2
Details	M-CSA 402

Chain	Residue	Details
A	HIS159	activator, proton shuttle (general acid/base)
A	LYS163	activator, electrostatic stabiliser, proton shuttle (general acid/base)

---