Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003723 | molecular_function | RNA binding |
A | 0003729 | molecular_function | mRNA binding |
A | 0004146 | molecular_function | dihydrofolate reductase activity |
A | 0005739 | cellular_component | mitochondrion |
A | 0006545 | biological_process | glycine biosynthetic process |
A | 0006730 | biological_process | one-carbon metabolic process |
A | 0008144 | molecular_function | obsolete drug binding |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0031427 | biological_process | response to methotrexate |
A | 0046452 | biological_process | dihydrofolate metabolic process |
A | 0046653 | biological_process | tetrahydrofolate metabolic process |
A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
A | 0046655 | biological_process | folic acid metabolic process |
A | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA A 200 |
Chain | Residue |
A | GLU78 |
A | GLU78 |
A | TAP191 |
A | TAP191 |
A | HOH278 |
A | HOH278 |
site_id | AC2 |
Number of Residues | 34 |
Details | BINDING SITE FOR RESIDUE TAP A 191 |
Chain | Residue |
A | GLY20 |
A | ASN21 |
A | LEU22 |
A | GLY53 |
A | LYS54 |
A | LYS55 |
A | THR56 |
A | LEU75 |
A | SER76 |
A | ARG77 |
A | GLU78 |
A | GLU78 |
A | LYS91 |
A | SER92 |
A | VAL115 |
A | GLY117 |
A | THR118 |
A | ALA119 |
A | VAL120 |
A | TYR121 |
A | THR146 |
A | HBI198 |
A | CA200 |
A | CA200 |
A | HOH220 |
A | HOH278 |
A | HOH318 |
A | HOH392 |
A | HOH393 |
A | HOH493 |
A | HOH648 |
A | ALA9 |
A | ILE16 |
A | GLY17 |
site_id | AC3 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE HBI A 198 |
Chain | Residue |
A | ILE7 |
A | LEU22 |
A | GLU30 |
A | PHE34 |
A | VAL115 |
A | TAP191 |
A | HOH648 |
Functional Information from PROSITE/UniProt
site_id | PS00075 |
Number of Residues | 24 |
Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. GIGkdgnLPWpplrnEykyFqrmT |
Chain | Residue | Details |
A | GLY15-THR38 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | ALA9 | |
A | LYS54 | |
A | SER76 | |
Chain | Residue | Details |
A | GLY15 | |
A | GLU30 | |
A | ARG70 | |
A | GLY116 | |
Chain | Residue | Details |
A | ASN64 | |