1DQX

CRYSTAL STRUCTURE OF OROTIDINE 5'-PHOSPHATE DECARBOXYLASE COMPLEXED TO 6-HYDROXYURIDINE 5'-PHOSPHATE (BMP)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004590	molecular_function	orotidine-5'-phosphate decarboxylase activity
A	0005829	cellular_component	cytosol
A	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0006222	biological_process	UMP biosynthetic process
A	0016829	molecular_function	lyase activity
A	0016831	molecular_function	carboxy-lyase activity
A	0044205	biological_process	'de novo' UMP biosynthetic process
B	0004590	molecular_function	orotidine-5'-phosphate decarboxylase activity
B	0005829	cellular_component	cytosol
B	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0006222	biological_process	UMP biosynthetic process
B	0016829	molecular_function	lyase activity
B	0016831	molecular_function	carboxy-lyase activity
B	0044205	biological_process	'de novo' UMP biosynthetic process
C	0004590	molecular_function	orotidine-5'-phosphate decarboxylase activity
C	0005829	cellular_component	cytosol
C	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
C	0006221	biological_process	pyrimidine nucleotide biosynthetic process
C	0006222	biological_process	UMP biosynthetic process
C	0016829	molecular_function	lyase activity
C	0016831	molecular_function	carboxy-lyase activity
C	0044205	biological_process	'de novo' UMP biosynthetic process
D	0004590	molecular_function	orotidine-5'-phosphate decarboxylase activity
D	0005829	cellular_component	cytosol
D	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
D	0006221	biological_process	pyrimidine nucleotide biosynthetic process
D	0006222	biological_process	UMP biosynthetic process
D	0016829	molecular_function	lyase activity
D	0016831	molecular_function	carboxy-lyase activity
D	0044205	biological_process	'de novo' UMP biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE BMP A 601

Chain	Residue
A	SER35
A	GLN215
A	TYR217
A	GLY234
A	ARG235
A	HOH625
A	HOH628
B	ASP96
B	ILE97
B	THR100
A	ASP37
A	LYS59
A	HIS61
A	ASP91
A	LYS93
A	LEU153
A	SER154
A	PRO202

---

site_id	AC2
Number of Residues	18
Details	BINDING SITE FOR RESIDUE BMP B 602

Chain	Residue
A	ASP96
A	ILE97
A	THR100
B	SER35
B	ASP37
B	LYS59
B	HIS61
B	ASP91
B	LYS93
B	LEU153
B	SER154
B	PRO202
B	GLN215
B	TYR217
B	GLY234
B	ARG235
B	HOH630
B	HOH677

---

site_id	AC3
Number of Residues	18
Details	BINDING SITE FOR RESIDUE BMP C 603

Chain	Residue
C	SER35
C	ASP37
C	LYS59
C	HIS61
C	ASP91
C	LYS93
C	LEU153
C	SER154
C	PRO202
C	GLN215
C	TYR217
C	GLY234
C	ARG235
C	HOH622
C	HOH637
D	ASP96
D	ILE97
D	THR100

---

site_id	AC4
Number of Residues	17
Details	BINDING SITE FOR RESIDUE BMP D 604

Chain	Residue
C	ASP96
C	ILE97
C	THR100
D	SER35
D	ASP37
D	LYS59
D	HIS61
D	ASP91
D	LYS93
D	LEU153
D	SER154
D	PRO202
D	GLN215
D	TYR217
D	GLY234
D	ARG235
D	HOH609

---

Functional Information from PROSITE/UniProt

site_id	PS00156
Number of Residues	14
Details	OMPDECASE Orotidine 5'-phosphate decarboxylase active site. LFeDrKfaDIGnTV

Chain	Residue	Details
A	LEU88-VAL101

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton donor"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	56
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	16
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"12872131","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1dbt

Chain	Residue	Details
A	ASP91
A	LYS93

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1dbt

Chain	Residue	Details
B	ASP91
B	LYS93

---

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1dbt

Chain	Residue	Details
C	ASP91
C	LYS93

---

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1dbt

Chain	Residue	Details
D	ASP91
D	LYS93

---

site_id	CSA5
Number of Residues	4
Details	Annotated By Reference To The Literature 1dbt

Chain	Residue	Details
A	LYS59
A	ASP96
A	ASP91
A	LYS93

---

site_id	CSA6
Number of Residues	4
Details	Annotated By Reference To The Literature 1dbt

Chain	Residue	Details
B	LYS59
B	ASP96
B	ASP91
B	LYS93

---

site_id	CSA7
Number of Residues	4
Details	Annotated By Reference To The Literature 1dbt

Chain	Residue	Details
C	LYS59
C	ASP96
C	ASP91
C	LYS93

---

site_id	CSA8
Number of Residues	4
Details	Annotated By Reference To The Literature 1dbt

Chain	Residue	Details
D	LYS59
D	ASP96
D	ASP91
D	LYS93

---