1DOA

Structure of the rho family gtp-binding protein cdc42 in complex with the multifunctional regulator rhogdi

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0000322	cellular_component	storage vacuole
A	0003015	biological_process	heart process
A	0003253	biological_process	cardiac neural crest cell migration involved in outflow tract morphogenesis
A	0003924	molecular_function	GTPase activity
A	0003925	molecular_function	G protein activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005813	cellular_component	centrosome
A	0005819	cellular_component	spindle
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0005911	cellular_component	cell-cell junction
A	0005925	cellular_component	focal adhesion
A	0006897	biological_process	endocytosis
A	0006911	biological_process	phagocytosis, engulfment
A	0007015	biological_process	actin filament organization
A	0007030	biological_process	Golgi organization
A	0007163	biological_process	establishment or maintenance of cell polarity
A	0007165	biological_process	signal transduction
A	0007229	biological_process	integrin-mediated signaling pathway
A	0007264	biological_process	small GTPase-mediated signal transduction
A	0009653	biological_process	anatomical structure morphogenesis
A	0010591	biological_process	regulation of lamellipodium assembly
A	0010592	biological_process	positive regulation of lamellipodium assembly
A	0015630	cellular_component	microtubule cytoskeleton
A	0016020	cellular_component	membrane
A	0017119	cellular_component	Golgi transport complex
A	0019901	molecular_function	protein kinase binding
A	0021762	biological_process	substantia nigra development
A	0030010	biological_process	establishment of cell polarity
A	0030036	biological_process	actin cytoskeleton organization
A	0030175	cellular_component	filopodium
A	0030225	biological_process	macrophage differentiation
A	0030307	biological_process	positive regulation of cell growth
A	0030335	biological_process	positive regulation of cell migration
A	0030425	cellular_component	dendrite
A	0030496	cellular_component	midbody
A	0030742	molecular_function	GTP-dependent protein binding
A	0031252	cellular_component	cell leading edge
A	0031256	cellular_component	leading edge membrane
A	0031274	biological_process	positive regulation of pseudopodium assembly
A	0031333	biological_process	negative regulation of protein-containing complex assembly
A	0031996	molecular_function	thioesterase binding
A	0032427	molecular_function	GBD domain binding
A	0032467	biological_process	positive regulation of cytokinesis
A	0032956	biological_process	regulation of actin cytoskeleton organization
A	0032991	cellular_component	protein-containing complex
A	0034191	molecular_function	apolipoprotein A-I receptor binding
A	0034329	biological_process	cell junction assembly
A	0035050	biological_process	embryonic heart tube development
A	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
A	0038189	biological_process	neuropilin signaling pathway
A	0042802	molecular_function	identical protein binding
A	0043005	cellular_component	neuron projection
A	0043025	cellular_component	neuronal cell body
A	0044788	biological_process	host-mediated perturbation of viral process
A	0045177	cellular_component	apical part of cell
A	0045198	biological_process	establishment of epithelial cell apical/basal polarity
A	0045335	cellular_component	phagocytic vesicle
A	0048549	biological_process	positive regulation of pinocytosis
A	0051130	biological_process	positive regulation of cellular component organization
A	0051233	cellular_component	spindle midzone
A	0051489	biological_process	regulation of filopodium assembly
A	0051491	biological_process	positive regulation of filopodium assembly
A	0051492	biological_process	regulation of stress fiber assembly
A	0051496	biological_process	positive regulation of stress fiber assembly
A	0051683	biological_process	establishment of Golgi localization
A	0051988	biological_process	regulation of attachment of spindle microtubules to kinetochore
A	0060071	biological_process	Wnt signaling pathway, planar cell polarity pathway
A	0060501	biological_process	positive regulation of epithelial cell proliferation involved in lung morphogenesis
A	0060997	biological_process	dendritic spine morphogenesis
A	0061630	molecular_function	ubiquitin protein ligase activity
A	0070062	cellular_component	extracellular exosome
A	0071944	cellular_component	cell periphery
A	0072384	biological_process	organelle transport along microtubule
A	0072686	cellular_component	mitotic spindle
A	0086100	biological_process	endothelin receptor signaling pathway
A	0098794	cellular_component	postsynapse
A	0098978	cellular_component	glutamatergic synapse
A	0099175	biological_process	regulation of postsynapse organization
A	1900026	biological_process	positive regulation of substrate adhesion-dependent cell spreading
B	0001772	cellular_component	immunological synapse
B	0005094	molecular_function	Rho GDP-dissociation inhibitor activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0007266	biological_process	Rho protein signal transduction
B	0016020	cellular_component	membrane
B	0071526	biological_process	semaphorin-plexin signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 199

Chain	Residue
A	THR17
A	THR35
A	ASP57
A	GDP198
A	HOH701
A	HOH749

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 200

Chain	Residue
A	HOH709
A	HOH709
A	HOH709
A	HIS0
A	HIS0
A	HIS0

---

site_id	AC3
Number of Residues	17
Details	BINDING SITE FOR RESIDUE GDP A 198

Chain	Residue
A	GLY12
A	ALA13
A	VAL14
A	GLY15
A	LYS16
A	THR17
A	CYS18
A	PHE28
A	VAL33
A	GLN116
A	ASP118
A	SER158
A	ALA159
A	LEU160
A	MG199
A	HOH701
A	HOH749

---

site_id	AC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GER A 952

Chain	Residue
A	ARG186
A	CMT188
B	ILE14
B	LEU75
B	TYR110
B	GLN130
B	THR132
B	ASP140
B	ALA171
B	TRP194
B	LEU196

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Motif: {"description":"Effector region","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	10
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"(Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate","evidences":[{"source":"PubMed","id":"19362538","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20622875","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"(Microbial infection) O-AMP-threonine; by Vibrio VopS","evidences":[{"source":"PubMed","id":"19039103","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine; by SRC","evidences":[{"source":"PubMed","id":"14506284","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Glycosylation: {"description":"(Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate","evidences":[{"source":"PubMed","id":"24141704","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Glycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB; alternate","evidences":[{"source":"PubMed","id":"24905543","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7775453","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7777059","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	17
Details	Region: {"description":"Hydrophobic"}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q99PT1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q99PT1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P52565","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by PKA","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	3
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P52565","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	1
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q99PT1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	3
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"UniProtKB","id":"P52565","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
A	GLN61

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
A	ALA13

---