Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004517 | molecular_function | nitric-oxide synthase activity |
| A | 0006809 | biological_process | nitric oxide biosynthetic process |
| B | 0004517 | molecular_function | nitric-oxide synthase activity |
| B | 0006809 | biological_process | nitric oxide biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT A 1850 |
| Chain | Residue |
| A | ARG252 |
| A | ASN368 |
| A | ARG374 |
| A | HOH2000 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT A 1860 |
| Chain | Residue |
| A | GLY188 |
| A | TRP358 |
| A | SER428 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CAC A 950 |
| Chain | Residue |
| A | ARG440 |
| A | GLY441 |
| A | TRP324 |
| A | CYS384 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT B 2850 |
| Chain | Residue |
| B | GLN249 |
| B | ARG252 |
| B | ASN368 |
| B | ARG374 |
| B | HOH2988 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACT B 2860 |
| Chain | Residue |
| B | TRP358 |
| B | VAL420 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CAC B 950 |
| Chain | Residue |
| B | TRP324 |
| B | CYS384 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 900 |
| Chain | Residue |
| A | CYS96 |
| A | CYS101 |
| B | CYS96 |
| B | CYS101 |
| site_id | AC8 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE HEM A 1500 |
| Chain | Residue |
| A | TRP180 |
| A | ARG185 |
| A | CYS186 |
| A | SER228 |
| A | PHE355 |
| A | SER356 |
| A | TRP358 |
| A | GLU363 |
| A | TYR477 |
| A | H4B1600 |
| A | TZC1790 |
| A | HOH1915 |
| A | HOH1936 |
| A | HOH2012 |
| site_id | AC9 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE HEM B 2500 |
| Chain | Residue |
| B | TRP180 |
| B | ARG185 |
| B | CYS186 |
| B | SER228 |
| B | MET341 |
| B | PHE355 |
| B | SER356 |
| B | TRP358 |
| B | GLU363 |
| B | TYR477 |
| B | H4B2600 |
| B | TZC2790 |
| B | HOH2893 |
| B | HOH2954 |
| B | HOH2992 |
| B | HOH2995 |
| B | HOH2998 |
| site_id | BC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE H4B A 1600 |
| Chain | Residue |
| A | SER104 |
| A | ARG367 |
| A | ALA448 |
| A | TRP449 |
| A | HEM1500 |
| A | GOL1880 |
| A | HOH1889 |
| A | HOH2014 |
| B | TRP447 |
| B | PHE462 |
| B | HIS463 |
| B | GLN464 |
| B | GLU465 |
| B | HOH2881 |
| site_id | BC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE TZC A 1790 |
| Chain | Residue |
| A | PRO336 |
| A | VAL338 |
| A | PHE355 |
| A | SER356 |
| A | GLY357 |
| A | TRP358 |
| A | GLU363 |
| A | HEM1500 |
| site_id | BC3 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE H4B B 2600 |
| Chain | Residue |
| A | PHE462 |
| B | SER104 |
| B | ARG367 |
| B | ALA448 |
| B | TRP449 |
| B | HEM2500 |
| B | GOL2880 |
| B | HOH2884 |
| B | HOH2934 |
| B | HOH2983 |
| B | HOH2992 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE TZC B 2790 |
| Chain | Residue |
| B | PRO336 |
| B | PHE355 |
| B | GLY357 |
| B | TRP358 |
| B | GLU363 |
| B | HEM2500 |
| site_id | BC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 1880 |
| Chain | Residue |
| B | TRP76 |
| B | HOH2881 |
| A | VAL106 |
| A | ARG367 |
| A | HIS373 |
| A | TRP449 |
| A | H4B1600 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 2880 |
| Chain | Residue |
| B | VAL106 |
| B | ARG367 |
| B | HIS373 |
| B | TRP449 |
| B | H4B2600 |
| B | HOH2884 |
Functional Information from PROSITE/UniProt
| site_id | PS60001 |
| Number of Residues | 8 |
| Details | NOS Nitric oxide synthase (NOS) signature. RCVGRIqW |
| Chain | Residue | Details |
| A | ARG185-TRP192 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P35228","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P29474","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"description":"axial binding residue","evidences":[{"source":"UniProtKB","id":"P29474","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by CDK5","evidences":[{"source":"UniProtKB","id":"P29474","evidenceCode":"ECO:0000250"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 3nos |
| Chain | Residue | Details |
| A | CYS186 | |
| A | ARG189 | |
| A | GLU363 | |
| A | TRP358 | |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 3nos |
| Chain | Residue | Details |
| B | CYS186 | |
| B | ARG189 | |
| B | GLU363 | |
| B | TRP358 | |
