1DM5
ANNEXIN XII E105K HOMOHEXAMER CRYSTAL STRUCTURE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001786 | molecular_function | phosphatidylserine binding |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005544 | molecular_function | calcium-dependent phospholipid binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0012506 | cellular_component | vesicle membrane |
| B | 0001786 | molecular_function | phosphatidylserine binding |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0005544 | molecular_function | calcium-dependent phospholipid binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0012506 | cellular_component | vesicle membrane |
| C | 0001786 | molecular_function | phosphatidylserine binding |
| C | 0005509 | molecular_function | calcium ion binding |
| C | 0005544 | molecular_function | calcium-dependent phospholipid binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0012506 | cellular_component | vesicle membrane |
| D | 0001786 | molecular_function | phosphatidylserine binding |
| D | 0005509 | molecular_function | calcium ion binding |
| D | 0005544 | molecular_function | calcium-dependent phospholipid binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0012506 | cellular_component | vesicle membrane |
| E | 0001786 | molecular_function | phosphatidylserine binding |
| E | 0005509 | molecular_function | calcium ion binding |
| E | 0005544 | molecular_function | calcium-dependent phospholipid binding |
| E | 0005634 | cellular_component | nucleus |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005886 | cellular_component | plasma membrane |
| E | 0012506 | cellular_component | vesicle membrane |
| F | 0001786 | molecular_function | phosphatidylserine binding |
| F | 0005509 | molecular_function | calcium ion binding |
| F | 0005544 | molecular_function | calcium-dependent phospholipid binding |
| F | 0005634 | cellular_component | nucleus |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005886 | cellular_component | plasma membrane |
| F | 0012506 | cellular_component | vesicle membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 1121 |
| Chain | Residue |
| A | MET98 |
| A | GLY102 |
| A | THR103 |
| A | GLU142 |
| E | LYS68 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA B 1122 |
| Chain | Residue |
| B | MET98 |
| B | GLY100 |
| B | GLY102 |
| B | GLU142 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA C 1123 |
| Chain | Residue |
| C | MET98 |
| C | LYS99 |
| C | GLY100 |
| C | GLY102 |
| C | HOH1240 |
| C | HOH1255 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA D 1124 |
| Chain | Residue |
| D | MET98 |
| D | LYS99 |
| D | GLY100 |
| D | GLY102 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA E 1125 |
| Chain | Residue |
| E | MET98 |
| E | LYS99 |
| E | GLY100 |
| E | HOH1213 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA F 1126 |
| Chain | Residue |
| F | MET98 |
| F | GLY100 |
| F | LEU101 |
| F | GLY102 |
| F | HOH1260 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA A 1131 |
| Chain | Residue |
| A | GLY181 |
| A | GLN184 |
| A | ILE185 |
| A | GLY186 |
| A | THR187 |
| A | GLU226 |
| A | HOH1255 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA B 1132 |
| Chain | Residue |
| B | GLY181 |
| B | GLN184 |
| B | ILE185 |
| B | GLY186 |
| B | GLU226 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA C 1133 |
| Chain | Residue |
| C | GLY181 |
| C | GLN184 |
| C | ILE185 |
| C | GLY186 |
| C | GLU226 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA D 1134 |
| Chain | Residue |
| D | GLY181 |
| D | GLN184 |
| D | ILE185 |
| D | GLY186 |
| D | GLU226 |
| D | HOH1258 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA E 1135 |
| Chain | Residue |
| E | GLY181 |
| E | GLN184 |
| E | ILE185 |
| E | GLY186 |
| E | GLU226 |
Functional Information from PROSITE/UniProt
| site_id | PS00223 |
| Number of Residues | 53 |
| Details | ANNEXIN_1 Annexin repeat signature. GTdeksithiLatRsnaQrqQiktdYttlfgkhLedeLkselsGnyeaaAlaL |
| Chain | Residue | Details |
| A | GLY30-LEU82 | |
| A | GLY186-ILE238 | |
| A | GLY261-ILE313 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 426 |
| Details | Repeat: {"description":"Annexin 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 426 |
| Details | Repeat: {"description":"Annexin 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 432 |
| Details | Repeat: {"description":"Annexin 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 426 |
| Details | Repeat: {"description":"Annexin 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | Modified residue: {"description":"Phosphothreonine; by PKC","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
