1DM3
ACETYLATED BIOSYNTHETIC THIOLASE FROM ZOOGLOEA RAMIGERA IN COMPLEX WITH ACETYL-COA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003985 | molecular_function | acetyl-CoA C-acetyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| A | 0042619 | biological_process | poly-hydroxybutyrate biosynthetic process |
| B | 0003985 | molecular_function | acetyl-CoA C-acetyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0042619 | biological_process | poly-hydroxybutyrate biosynthetic process |
| C | 0003985 | molecular_function | acetyl-CoA C-acetyltransferase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0016746 | molecular_function | acyltransferase activity |
| C | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| C | 0042619 | biological_process | poly-hydroxybutyrate biosynthetic process |
| D | 0003985 | molecular_function | acetyl-CoA C-acetyltransferase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0016746 | molecular_function | acyltransferase activity |
| D | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| D | 0042619 | biological_process | poly-hydroxybutyrate biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 807 |
| Chain | Residue |
| B | LYS298 |
| B | ARG302 |
| B | HOH983 |
| B | HOH1029 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 808 |
| Chain | Residue |
| A | SER260 |
| A | GLU263 |
| A | ARG266 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 809 |
| Chain | Residue |
| B | ARG266 |
| B | HOH991 |
| B | SER260 |
| B | GLU263 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 810 |
| Chain | Residue |
| A | LYS298 |
| A | ARG302 |
| A | HOH966 |
| A | HOH1088 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 811 |
| Chain | Residue |
| A | ARG41 |
| A | ILE199 |
| A | VAL200 |
| A | HOH968 |
| A | HOH1063 |
| A | HOH1108 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 812 |
| Chain | Residue |
| B | ARG41 |
| B | ILE199 |
| B | VAL200 |
| B | HOH984 |
| B | HOH1052 |
| B | HOH1054 |
| site_id | AC7 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE ACO A 813 |
| Chain | Residue |
| A | SCY89 |
| A | LEU148 |
| A | HIS156 |
| A | MET157 |
| A | ARG220 |
| A | SER227 |
| A | MET228 |
| A | ALA243 |
| A | GLY244 |
| A | SER247 |
| A | GLY248 |
| A | MET288 |
| A | ALA318 |
| A | PHE319 |
| A | HIS348 |
| A | CYS378 |
| A | HOH846 |
| A | HOH879 |
| A | HOH902 |
| A | HOH908 |
| A | HOH936 |
| A | HOH949 |
| A | HOH976 |
| A | HOH978 |
| A | HOH1001 |
| A | HOH1109 |
| D | MET134 |
| site_id | AC8 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE ACO B 814 |
| Chain | Residue |
| B | SCY89 |
| B | LEU148 |
| B | HIS156 |
| B | MET157 |
| B | ARG220 |
| B | SER227 |
| B | MET228 |
| B | ALA243 |
| B | GLY244 |
| B | SER247 |
| B | GLY248 |
| B | MET288 |
| B | ALA318 |
| B | PHE319 |
| B | HIS348 |
| B | CYS378 |
| B | ILE379 |
| B | GLY380 |
| B | HOH829 |
| B | HOH854 |
| B | HOH857 |
| B | HOH880 |
| B | HOH896 |
| B | HOH1022 |
| B | HOH1096 |
| C | MET134 |
| site_id | AC9 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE ACO C 815 |
| Chain | Residue |
| C | HOH908 |
| C | SCY89 |
| C | LEU148 |
| C | HIS156 |
| C | MET157 |
| C | ARG220 |
| C | SER227 |
| C | MET228 |
| C | PHE235 |
| C | ALA243 |
| C | GLY244 |
| C | SER247 |
| C | GLY248 |
| C | MET288 |
| C | ALA318 |
| C | PHE319 |
| C | HIS348 |
| C | CYS378 |
| C | ILE379 |
| C | HOH881 |
| site_id | BC1 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE ACO D 816 |
| Chain | Residue |
| D | SCY89 |
| D | LEU148 |
| D | HIS156 |
| D | MET157 |
| D | GLN183 |
| D | ARG220 |
| D | MET228 |
| D | PHE235 |
| D | ALA243 |
| D | GLY244 |
| D | SER247 |
| D | GLY248 |
| D | LEU249 |
| D | MET288 |
| D | ALA318 |
| D | PHE319 |
| D | HIS348 |
| D | CYS378 |
| D | ILE379 |
| D | GLY380 |
| D | HOH845 |
| D | HOH855 |
Functional Information from PROSITE/UniProt
| site_id | PS00098 |
| Number of Residues | 19 |
| Details | THIOLASE_1 Thiolases acyl-enzyme intermediate signature. MNQlCGSGLrAValgmqqI |
| Chain | Residue | Details |
| A | MET85-ILE103 |
| site_id | PS00099 |
| Number of Residues | 14 |
| Details | THIOLASE_3 Thiolases active site. GLATLCIGgGmGvA |
| Chain | Residue | Details |
| A | GLY373-ALA386 |
| site_id | PS00737 |
| Number of Residues | 17 |
| Details | THIOLASE_2 Thiolases signature 2. NvnGGaIAiGHPiGaSG |
| Chain | Residue | Details |
| A | ASN338-GLY354 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Acyl-thioester intermediate |
| Chain | Residue | Details |
| A | SCY89 | |
| B | SCY89 | |
| C | SCY89 | |
| D | SCY89 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | ACT_SITE: Proton acceptor |
| Chain | Residue | Details |
| A | HIS348 | |
| A | CYS378 | |
| B | HIS348 | |
| B | CYS378 | |
| C | HIS348 | |
| C | CYS378 | |
| D | HIS348 | |
| D | CYS378 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1afw |
| Chain | Residue | Details |
| A | HIS348 | |
| A | GLY380 | |
| A | CYS378 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1afw |
| Chain | Residue | Details |
| B | HIS348 | |
| B | GLY380 | |
| B | CYS378 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1afw |
| Chain | Residue | Details |
| C | HIS348 | |
| C | GLY380 | |
| C | CYS378 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1afw |
| Chain | Residue | Details |
| D | HIS348 | |
| D | GLY380 | |
| D | CYS378 |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1afw |
| Chain | Residue | Details |
| A | HIS348 | |
| A | CYS378 |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1afw |
| Chain | Residue | Details |
| B | HIS348 | |
| B | CYS378 |
| site_id | CSA7 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1afw |
| Chain | Residue | Details |
| C | HIS348 | |
| C | CYS378 |
| site_id | CSA8 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1afw |
| Chain | Residue | Details |
| D | HIS348 | |
| D | CYS378 |
