Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0004252 | molecular_function | serine-type endopeptidase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0006508 | biological_process | proteolysis |
| B | 0007586 | biological_process | digestion |
| B | 0008233 | molecular_function | peptidase activity |
| B | 0008236 | molecular_function | serine-type peptidase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0097180 | cellular_component | serine protease inhibitor complex |
| B | 0097655 | molecular_function | serpin family protein binding |
| D | 0004252 | molecular_function | serine-type endopeptidase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005576 | cellular_component | extracellular region |
| D | 0006508 | biological_process | proteolysis |
| D | 0007586 | biological_process | digestion |
| D | 0008233 | molecular_function | peptidase activity |
| D | 0008236 | molecular_function | serine-type peptidase activity |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0097180 | cellular_component | serine protease inhibitor complex |
| D | 0097655 | molecular_function | serpin family protein binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 400 |
| Chain | Residue |
| B | LYS90 |
| B | HOH504 |
| D | GLY59 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR CHAIN E OF PEPTIDIC INHIBITOR |
| Chain | Residue |
| B | GLY193 |
| B | SER195 |
| B | SER214 |
| B | TRP215 |
| B | GLY216 |
| B | SER217 |
| B | HOH453 |
| D | SER218 |
| E | HOH441 |
| F | HOH294 |
| B | HIS57 |
| B | LEU97 |
| B | THR98 |
| B | LYS175 |
| B | SER190 |
| B | MET192 |
| site_id | AC3 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR CHAIN F OF PEPTIDIC INHIBITOR |
| Chain | Residue |
| B | MET192 |
| B | SER218 |
| D | HIS57 |
| D | LEU97 |
| D | THR98 |
| D | LYS175 |
| D | SER190 |
| D | GLY193 |
| D | SER195 |
| D | SER214 |
| D | TRP215 |
| D | GLY216 |
| D | SER217 |
| D | HOH275 |
| D | HOH290 |
| D | HOH386 |
| E | HOH441 |
| F | HOH294 |
| F | HOH383 |
Functional Information from PROSITE/UniProt
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VTAAHC |
| Chain | Residue | Details |
| B | VAL53-CYS58 | |
| site_id | PS00135 |
| Number of Residues | 12 |
| Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. SScmGDSGGPLV |
| Chain | Residue | Details |
| B | SER189-VAL200 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | ACT_SITE: Charge relay system |
| Chain | Residue | Details |
| B | HIS57 | |
| B | ASP102 | |
| B | SER195 | |
| D | HIS57 | |
| D | ASP102 | |
| D | SER195 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | ASP102 | |
| B | SER195 | |
| B | HIS57 | |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| D | ASP102 | |
| D | SER195 | |
| D | HIS57 | |
| site_id | CSA3 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | ASP102 | |
| B | SER195 | |
| B | GLY193 | |
| B | HIS57 | |
| site_id | CSA4 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| D | ASP102 | |
| D | SER195 | |
| D | GLY193 | |
| D | HIS57 | |
| site_id | CSA5 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | ASP102 | |
| B | SER195 | |
| B | HIS57 | |
| B | GLY196 | |
| site_id | CSA6 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| D | ASP102 | |
| D | SER195 | |
| D | HIS57 | |
| D | GLY196 | |
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 387 |
| Chain | Residue | Details |
| B | HIS57 | electrostatic stabiliser, proton shuttle (general acid/base) |
| B | ASP102 | modifies pKa |
| B | GLY193 | electrostatic stabiliser |
| B | SER195 | covalent catalysis |
| B | GLY196 | electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | 5 |
| Details | M-CSA 387 |
| Chain | Residue | Details |
| D | HIS57 | electrostatic stabiliser, proton shuttle (general acid/base) |
| D | ASP102 | modifies pKa |
| D | GLY193 | electrostatic stabiliser |
| D | SER195 | covalent catalysis |
| D | GLY196 | electrostatic stabiliser |
