1DK8
CRYSTAL STRUCTURE OF THE RGS-HOMOLOGOUS DOMAIN OF AXIN
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0090090 | biological_process | negative regulation of canonical Wnt signaling pathway |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE SO4 A 501 |
| Chain | Residue |
| A | PHE142 |
| A | HOH337 |
| A | HOH371 |
| A | HOH405 |
| A | HOH449 |
| A | HOH455 |
| A | LYS184 |
| A | TYR185 |
| A | LYS240 |
| A | SER241 |
| A | ASP242 |
| A | HOH308 |
| A | HOH311 |
| A | HOH314 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 502 |
| Chain | Residue |
| A | THR116 |
| A | LYS121 |
| A | LYS240 |
| A | HOH412 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 503 |
| Chain | Residue |
| A | ARG140 |
| A | LYS144 |
| A | SER237 |
| A | HOH370 |
| A | HOH410 |
| A | HOH438 |
| A | HOH472 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 504 |
| Chain | Residue |
| A | SER137 |
| A | ARG195 |
| A | GLN196 |
| A | HOH404 |
| A | HOH443 |
| A | SO4506 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 505 |
| Chain | Residue |
| A | GLY251 |
| A | SER252 |
| A | HOH331 |
| A | HOH350 |
| A | HOH372 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 506 |
| Chain | Residue |
| A | THR141 |
| A | LYS144 |
| A | LYS163 |
| A | HOH363 |
| A | SO4504 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE DTT A 701 |
| Chain | Residue |
| A | GLU124 |
| A | SER125 |
| A | LEU126 |
| A | HIS127 |
| A | GLU231 |
| A | TYR235 |
| A | HOH398 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 601 |
| Chain | Residue |
| A | CYS167 |
| A | ASP168 |
| A | SER169 |
| A | LYS202 |
| A | SER203 |
| A | LYS206 |
| A | HOH320 |
| A | GOL602 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 602 |
| Chain | Residue |
| A | ASP168 |
| A | ALA200 |
| A | SER203 |
| A | LYS206 |
| A | HOH457 |
| A | HOH477 |
| A | GOL601 |
| A | GOL605 |
| site_id | BC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 603 |
| Chain | Residue |
| A | CYS208 |
| A | CYS208 |
| A | LEU213 |
| A | LEU213 |
| A | ILE214 |
| A | ASP215 |
| A | ASP215 |
| A | HOH364 |
| A | HOH364 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 604 |
| Chain | Residue |
| A | TYR119 |
| A | ARG249 |
| A | ARG249 |
| site_id | BC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 605 |
| Chain | Residue |
| A | PRO199 |
| A | ALA200 |
| A | SER203 |
| A | SER203 |
| A | HOH444 |
| A | HOH457 |
| A | GOL602 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 123 |
| Details | Domain: {"description":"RGS","evidences":[{"source":"PROSITE-ProRule","id":"PRU00171","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by CK1","evidences":[{"source":"PubMed","id":"17318175","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by CK1","evidences":[{"source":"PubMed","id":"17318175","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
