1DJ2

STRUCTURES OF ADENYLOSUCCINATE SYNTHETASE FROM TRITICUM AESTIVUM AND ARABIDOPSIS THALIANA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0004019	molecular_function	adenylosuccinate synthase activity
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006164	biological_process	purine nucleotide biosynthetic process
A	0009507	cellular_component	chloroplast
A	0009536	cellular_component	plastid
A	0009570	cellular_component	chloroplast stroma
A	0016874	molecular_function	ligase activity
A	0044208	biological_process	'de novo' AMP biosynthetic process
A	0046040	biological_process	IMP metabolic process
A	0046872	molecular_function	metal ion binding
A	0048046	cellular_component	apoplast
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0004019	molecular_function	adenylosuccinate synthase activity
B	0005525	molecular_function	GTP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006164	biological_process	purine nucleotide biosynthetic process
B	0009507	cellular_component	chloroplast
B	0009536	cellular_component	plastid
B	0009570	cellular_component	chloroplast stroma
B	0016874	molecular_function	ligase activity
B	0044208	biological_process	'de novo' AMP biosynthetic process
B	0046040	biological_process	IMP metabolic process
B	0046872	molecular_function	metal ion binding
B	0048046	cellular_component	apoplast

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE GDP A 500

Chain	Residue
A	GLY30
A	TYR62
A	LYS349
A	ASP351
A	GLY432
A	ILE433
A	GLY434
A	ASP31
A	GLY33
A	LYS34
A	GLY35
A	LYS36
A	GLY58
A	HIS59
A	THR60

---

site_id	AC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE GDP B 600

Chain	Residue
B	GLY30
B	ASP31
B	GLY33
B	LYS34
B	GLY35
B	LYS36
B	GLY58
B	HIS59
B	THR60
B	TYR62
B	LYS349
B	ASP351
B	GLY432
B	ILE433
B	GLY434
B	PRO435

---

Functional Information from PROSITE/UniProt

site_id	PS00513
Number of Residues	12
Details	ADENYLOSUCCIN_SYN_2 Adenylosuccinate synthetase active site. GIGPaYssKviR

Chain	Residue	Details
A	GLY151-ARG162

---

site_id	PS01266
Number of Residues	8
Details	ADENYLOSUCCIN_SYN_1 Adenylosuccinate synthetase GTP-binding site. QWGDEGKG

Chain	Residue	Details
A	GLN28-GLY35

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_03125","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Proton donor","evidences":[{"source":"HAMAP-Rule","id":"MF_03125","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	20
Details	Binding site: {"description":"in other chain","evidences":[{"source":"HAMAP-Rule","id":"MF_03125","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03125","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1gim

Chain	Residue	Details
A	GLN242
A	ASP31
A	HIS59

---

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1gim

Chain	Residue	Details
B	GLN242
B	ASP31
B	HIS59

---