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1DGH

HUMAN ERYTHROCYTE CATALASE 3-AMINO-1,2,4-TRIAZOLE COMPLEX

Functional Information from GO Data
ChainGOidnamespacecontents
A0000302biological_processresponse to reactive oxygen species
A0001649biological_processosteoblast differentiation
A0001657biological_processureteric bud development
A0001666biological_processresponse to hypoxia
A0001822biological_processkidney development
A0004046molecular_functionaminoacylase activity
A0004096molecular_functioncatalase activity
A0004601molecular_functionperoxidase activity
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005777cellular_componentperoxisome
A0005778cellular_componentperoxisomal membrane
A0005782cellular_componentperoxisomal matrix
A0005829cellular_componentcytosol
A0005925cellular_componentfocal adhesion
A0006641biological_processtriglyceride metabolic process
A0006979biological_processresponse to oxidative stress
A0008203biological_processcholesterol metabolic process
A0009060biological_processaerobic respiration
A0009410biological_processresponse to xenobiotic stimulus
A0009411biological_processresponse to UV
A0009636biological_processresponse to toxic substance
A0009642biological_processresponse to light intensity
A0009650biological_processUV protection
A0010193biological_processresponse to ozone
A0010288biological_processresponse to lead ion
A0014823biological_processresponse to activity
A0014854biological_processresponse to inactivity
A0016020cellular_componentmembrane
A0016209molecular_functionantioxidant activity
A0016684molecular_functionoxidoreductase activity, acting on peroxide as acceptor
A0019899molecular_functionenzyme binding
A0020027biological_processhemoglobin metabolic process
A0020037molecular_functionheme binding
A0032355biological_processresponse to estradiol
A0032868biological_processresponse to insulin
A0032991cellular_componentprotein-containing complex
A0033189biological_processresponse to vitamin A
A0033197biological_processresponse to vitamin E
A0033591biological_processresponse to L-ascorbic acid
A0034774cellular_componentsecretory granule lumen
A0042542biological_processresponse to hydrogen peroxide
A0042744biological_processhydrogen peroxide catabolic process
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0043066biological_processnegative regulation of apoptotic process
A0043231cellular_componentintracellular membrane-bounded organelle
A0045471biological_processresponse to ethanol
A0046686biological_processresponse to cadmium ion
A0046872molecular_functionmetal ion binding
A0050661molecular_functionNADP binding
A0051781biological_processpositive regulation of cell division
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0055093biological_processresponse to hyperoxia
A0061692biological_processcellular detoxification of hydrogen peroxide
A0062151cellular_componentcatalase complex
A0070062cellular_componentextracellular exosome
A0070542biological_processresponse to fatty acid
A0071363biological_processcellular response to growth factor stimulus
A0080184biological_processresponse to phenylpropanoid
A1904813cellular_componentficolin-1-rich granule lumen
B0000302biological_processresponse to reactive oxygen species
B0001649biological_processosteoblast differentiation
B0001657biological_processureteric bud development
B0001666biological_processresponse to hypoxia
B0001822biological_processkidney development
B0004046molecular_functionaminoacylase activity
B0004096molecular_functioncatalase activity
B0004601molecular_functionperoxidase activity
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005777cellular_componentperoxisome
B0005778cellular_componentperoxisomal membrane
B0005782cellular_componentperoxisomal matrix
B0005829cellular_componentcytosol
B0005925cellular_componentfocal adhesion
B0006641biological_processtriglyceride metabolic process
B0006979biological_processresponse to oxidative stress
B0008203biological_processcholesterol metabolic process
B0009060biological_processaerobic respiration
B0009410biological_processresponse to xenobiotic stimulus
B0009411biological_processresponse to UV
B0009636biological_processresponse to toxic substance
B0009642biological_processresponse to light intensity
B0009650biological_processUV protection
B0010193biological_processresponse to ozone
B0010288biological_processresponse to lead ion
B0014823biological_processresponse to activity
B0014854biological_processresponse to inactivity
B0016020cellular_componentmembrane
B0016209molecular_functionantioxidant activity
B0016684molecular_functionoxidoreductase activity, acting on peroxide as acceptor
B0019899molecular_functionenzyme binding
B0020027biological_processhemoglobin metabolic process
B0020037molecular_functionheme binding
B0032355biological_processresponse to estradiol
B0032868biological_processresponse to insulin
B0032991cellular_componentprotein-containing complex
B0033189biological_processresponse to vitamin A
B0033197biological_processresponse to vitamin E
B0033591biological_processresponse to L-ascorbic acid
B0034774cellular_componentsecretory granule lumen
B0042542biological_processresponse to hydrogen peroxide
B0042744biological_processhydrogen peroxide catabolic process
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0043066biological_processnegative regulation of apoptotic process
B0043231cellular_componentintracellular membrane-bounded organelle
B0045471biological_processresponse to ethanol
B0046686biological_processresponse to cadmium ion
B0046872molecular_functionmetal ion binding
B0050661molecular_functionNADP binding
B0051781biological_processpositive regulation of cell division
B0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B0055093biological_processresponse to hyperoxia
B0061692biological_processcellular detoxification of hydrogen peroxide
B0062151cellular_componentcatalase complex
B0070062cellular_componentextracellular exosome
B0070542biological_processresponse to fatty acid
B0071363biological_processcellular response to growth factor stimulus
B0080184biological_processresponse to phenylpropanoid
B1904813cellular_componentficolin-1-rich granule lumen
C0000302biological_processresponse to reactive oxygen species
C0001649biological_processosteoblast differentiation
C0001657biological_processureteric bud development
C0001666biological_processresponse to hypoxia
C0001822biological_processkidney development
C0004046molecular_functionaminoacylase activity
C0004096molecular_functioncatalase activity
C0004601molecular_functionperoxidase activity
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005777cellular_componentperoxisome
C0005778cellular_componentperoxisomal membrane
C0005782cellular_componentperoxisomal matrix
C0005829cellular_componentcytosol
C0005925cellular_componentfocal adhesion
C0006641biological_processtriglyceride metabolic process
C0006979biological_processresponse to oxidative stress
C0008203biological_processcholesterol metabolic process
C0009060biological_processaerobic respiration
C0009410biological_processresponse to xenobiotic stimulus
C0009411biological_processresponse to UV
C0009636biological_processresponse to toxic substance
C0009642biological_processresponse to light intensity
C0009650biological_processUV protection
C0010193biological_processresponse to ozone
C0010288biological_processresponse to lead ion
C0014823biological_processresponse to activity
C0014854biological_processresponse to inactivity
C0016020cellular_componentmembrane
C0016209molecular_functionantioxidant activity
C0016684molecular_functionoxidoreductase activity, acting on peroxide as acceptor
C0019899molecular_functionenzyme binding
C0020027biological_processhemoglobin metabolic process
C0020037molecular_functionheme binding
C0032355biological_processresponse to estradiol
C0032868biological_processresponse to insulin
C0032991cellular_componentprotein-containing complex
C0033189biological_processresponse to vitamin A
C0033197biological_processresponse to vitamin E
C0033591biological_processresponse to L-ascorbic acid
C0034774cellular_componentsecretory granule lumen
C0042542biological_processresponse to hydrogen peroxide
C0042744biological_processhydrogen peroxide catabolic process
C0042802molecular_functionidentical protein binding
C0042803molecular_functionprotein homodimerization activity
C0043066biological_processnegative regulation of apoptotic process
C0043231cellular_componentintracellular membrane-bounded organelle
C0045471biological_processresponse to ethanol
C0046686biological_processresponse to cadmium ion
C0046872molecular_functionmetal ion binding
C0050661molecular_functionNADP binding
C0051781biological_processpositive regulation of cell division
C0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C0055093biological_processresponse to hyperoxia
C0061692biological_processcellular detoxification of hydrogen peroxide
C0062151cellular_componentcatalase complex
C0070062cellular_componentextracellular exosome
C0070542biological_processresponse to fatty acid
C0071363biological_processcellular response to growth factor stimulus
C0080184biological_processresponse to phenylpropanoid
C1904813cellular_componentficolin-1-rich granule lumen
D0000302biological_processresponse to reactive oxygen species
D0001649biological_processosteoblast differentiation
D0001657biological_processureteric bud development
D0001666biological_processresponse to hypoxia
D0001822biological_processkidney development
D0004046molecular_functionaminoacylase activity
D0004096molecular_functioncatalase activity
D0004601molecular_functionperoxidase activity
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005777cellular_componentperoxisome
D0005778cellular_componentperoxisomal membrane
D0005782cellular_componentperoxisomal matrix
D0005829cellular_componentcytosol
D0005925cellular_componentfocal adhesion
D0006641biological_processtriglyceride metabolic process
D0006979biological_processresponse to oxidative stress
D0008203biological_processcholesterol metabolic process
D0009060biological_processaerobic respiration
D0009410biological_processresponse to xenobiotic stimulus
D0009411biological_processresponse to UV
D0009636biological_processresponse to toxic substance
D0009642biological_processresponse to light intensity
D0009650biological_processUV protection
D0010193biological_processresponse to ozone
D0010288biological_processresponse to lead ion
D0014823biological_processresponse to activity
D0014854biological_processresponse to inactivity
D0016020cellular_componentmembrane
D0016209molecular_functionantioxidant activity
D0016684molecular_functionoxidoreductase activity, acting on peroxide as acceptor
D0019899molecular_functionenzyme binding
D0020027biological_processhemoglobin metabolic process
D0020037molecular_functionheme binding
D0032355biological_processresponse to estradiol
D0032868biological_processresponse to insulin
D0032991cellular_componentprotein-containing complex
D0033189biological_processresponse to vitamin A
D0033197biological_processresponse to vitamin E
D0033591biological_processresponse to L-ascorbic acid
D0034774cellular_componentsecretory granule lumen
D0042542biological_processresponse to hydrogen peroxide
D0042744biological_processhydrogen peroxide catabolic process
D0042802molecular_functionidentical protein binding
D0042803molecular_functionprotein homodimerization activity
D0043066biological_processnegative regulation of apoptotic process
D0043231cellular_componentintracellular membrane-bounded organelle
D0045471biological_processresponse to ethanol
D0046686biological_processresponse to cadmium ion
D0046872molecular_functionmetal ion binding
D0050661molecular_functionNADP binding
D0051781biological_processpositive regulation of cell division
D0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
D0055093biological_processresponse to hyperoxia
D0061692biological_processcellular detoxification of hydrogen peroxide
D0062151cellular_componentcatalase complex
D0070062cellular_componentextracellular exosome
D0070542biological_processresponse to fatty acid
D0071363biological_processcellular response to growth factor stimulus
D0080184biological_processresponse to phenylpropanoid
D1904813cellular_componentficolin-1-rich granule lumen
Functional Information from PDB Data
site_idAC1
Number of Residues23
DetailsBINDING SITE FOR RESIDUE HEM A 2000
ChainResidue
AARG72
APHE161
AGLY216
ASER217
APHE334
AMET350
AARG354
ATYR358
ATHR361
AHIS362
AARG365
AVAL73
AHOH3143
AHOH3155
AHOH3186
CMET61
AVAL74
AHIS75
AARG112
AGLY131
AVAL146
AGLY147
AASN148

site_idAC2
Number of Residues20
DetailsBINDING SITE FOR RESIDUE NDP A 3000
ChainResidue
AHIS194
APHE198
ASER201
AARG203
AASN213
AHIS235
ALYS237
AVAL302
ATRP303
APRO304
AHIS305
AGLN442
APHE446
AVAL450
AHOH3028
AHOH3211
AHOH3259
AHOH3327
AHOH3369
AHOH3373

site_idAC3
Number of Residues25
DetailsBINDING SITE FOR RESIDUE HEM B 2001
ChainResidue
BARG72
BVAL73
BVAL74
B3AH75
BARG112
BGLY131
BVAL146
BGLY147
BASN148
BPRO158
BPHE161
BGLY216
BSER217
BLEU299
BPHE334
BMET350
BARG354
BTYR358
BTHR361
BHIS362
BARG365
BHOH2049
BHOH2060
BHOH2236
DMET61

site_idAC4
Number of Residues26
DetailsBINDING SITE FOR RESIDUE HEM C 2002
ChainResidue
AMET61
AASP65
CARG72
CVAL73
CVAL74
CHIS75
CARG112
CGLY131
CVAL146
CGLY147
CASN148
CPRO158
CPHE161
CGLY216
CSER217
CLEU299
CPHE334
CMET350
CARG354
CTYR358
CTHR361
CHIS362
CARG365
CHOH3058
CHOH3059
CHOH3141

site_idAC5
Number of Residues19
DetailsBINDING SITE FOR RESIDUE NDP C 3001
ChainResidue
CHIS235
CLYS237
CILE242
CTRP303
CPRO304
CHIS305
CGLN442
CPHE446
CVAL450
CHOH3158
CHOH3177
CHOH3201
CHOH3251
CHOH3368
CHIS194
CPHE198
CSER201
CARG203
CASN213

site_idAC6
Number of Residues23
DetailsBINDING SITE FOR RESIDUE HEM D 2003
ChainResidue
BASP65
DARG72
DVAL73
DVAL74
D3AH75
DARG112
DGLY131
DVAL146
DGLY147
DASN148
DPHE161
DGLY216
DSER217
DPHE334
DMET350
DARG354
DTYR358
DTHR361
DHIS362
DARG365
DHOH2025
DHOH2047
DHOH2138

Functional Information from PROSITE/UniProt
site_idPS00437
Number of Residues9
DetailsCATALASE_1 Catalase proximal heme-ligand signature. RLFAYpDTH
ChainResidueDetails
AARG354-HIS362
BARG354-HIS362

site_idPS00438
Number of Residues17
DetailsCATALASE_2 Catalase proximal active site signature. FdReripERvvHakGAG
ChainResidueDetails
APHE64-GLY80
BPHE64-GLY80

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: ACT_SITE => ECO:0000305|PubMed:10656833
ChainResidueDetails
BALA76
BASN149
DALA76
DASN149

site_idSWS_FT_FI2
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:10656833, ECO:0007744|PDB:1DGB, ECO:0007744|PDB:1DGF, ECO:0007744|PDB:1DGG, ECO:0007744|PDB:1DGH
ChainResidueDetails
BGLN195
DGLY214
DPRO304
DLYS306
BASP202
BGLY204
BGLY214
BPRO304
BLYS306
DGLN195
DASP202
DGLY204

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:10656833, ECO:0007744|PDB:1DGB, ECO:0007744|PDB:1DGF, ECO:0007744|PDB:1DGH
ChainResidueDetails
BTHR238
DTHR238

site_idSWS_FT_FI4
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:10656833, ECO:0007744|PDB:1DGF
ChainResidueDetails
BASP307
DASP307

site_idSWS_FT_FI5
Number of Residues2
DetailsBINDING: axial binding residue => ECO:0000269|PubMed:10656833, ECO:0000269|PubMed:10666617, ECO:0007744|PDB:1DGB, ECO:0007744|PDB:1DGF, ECO:0007744|PDB:1DGG, ECO:0007744|PDB:1DGH, ECO:0007744|PDB:1F4J, ECO:0007744|PDB:1QQW
ChainResidueDetails
BPRO359
DPRO359

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
BASP10
BILE423
DASP10
DILE423

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P24270
ChainResidueDetails
BLEU222
DLEU222

site_idSWS_FT_FI8
Number of Residues4
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P24270
ChainResidueDetails
BPHE234
BTYR500
DPHE234
DTYR500

site_idSWS_FT_FI9
Number of Residues4
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P24270
ChainResidueDetails
BASP307
BASN481
DASP307
DASN481

site_idSWS_FT_FI10
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P24270
ChainResidueDetails
BALA418
DALA418

Catalytic Information from CSA
site_idCSA1
Number of Residues3
DetailsAnnotated By Reference To The Literature 1iph
ChainResidueDetails
AHIS75
AASN148
ASER114

site_idCSA2
Number of Residues3
DetailsAnnotated By Reference To The Literature 1iph
ChainResidueDetails
CHIS75
CASN148
CSER114

site_idCSA3
Number of Residues2
DetailsAnnotated By Reference To The Literature 1iph
ChainResidueDetails
BSER114
BASN148

site_idCSA4
Number of Residues2
DetailsAnnotated By Reference To The Literature 1iph
ChainResidueDetails
DSER114
DASN148

222415

PDB entries from 2024-07-10

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