1DGF

HUMAN ERYTHROCYTE CATALASE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000302	biological_process	response to reactive oxygen species
A	0001649	biological_process	osteoblast differentiation
A	0001657	biological_process	ureteric bud development
A	0001666	biological_process	response to hypoxia
A	0001822	biological_process	kidney development
A	0004046	molecular_function	aminoacylase activity
A	0004096	molecular_function	catalase activity
A	0004601	molecular_function	peroxidase activity
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005777	cellular_component	peroxisome
A	0005778	cellular_component	peroxisomal membrane
A	0005782	cellular_component	peroxisomal matrix
A	0005829	cellular_component	cytosol
A	0005925	cellular_component	focal adhesion
A	0006641	biological_process	triglyceride metabolic process
A	0006979	biological_process	response to oxidative stress
A	0008203	biological_process	cholesterol metabolic process
A	0009060	biological_process	aerobic respiration
A	0009410	biological_process	response to xenobiotic stimulus
A	0009411	biological_process	response to UV
A	0009636	biological_process	response to toxic substance
A	0009642	biological_process	response to light intensity
A	0009650	biological_process	UV protection
A	0010193	biological_process	response to ozone
A	0010288	biological_process	response to lead ion
A	0014823	biological_process	response to activity
A	0014854	biological_process	response to inactivity
A	0016020	cellular_component	membrane
A	0016209	molecular_function	antioxidant activity
A	0016684	molecular_function	oxidoreductase activity, acting on peroxide as acceptor
A	0019899	molecular_function	enzyme binding
A	0020027	biological_process	hemoglobin metabolic process
A	0020037	molecular_function	heme binding
A	0032355	biological_process	response to estradiol
A	0032868	biological_process	response to insulin
A	0032991	cellular_component	protein-containing complex
A	0033189	biological_process	response to vitamin A
A	0033197	biological_process	response to vitamin E
A	0033591	biological_process	response to L-ascorbic acid
A	0034774	cellular_component	secretory granule lumen
A	0042542	biological_process	response to hydrogen peroxide
A	0042744	biological_process	hydrogen peroxide catabolic process
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0043066	biological_process	negative regulation of apoptotic process
A	0043231	cellular_component	intracellular membrane-bounded organelle
A	0045471	biological_process	response to ethanol
A	0046686	biological_process	response to cadmium ion
A	0046872	molecular_function	metal ion binding
A	0050661	molecular_function	NADP binding
A	0051781	biological_process	positive regulation of cell division
A	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A	0055093	biological_process	response to hyperoxia
A	0061692	biological_process	cellular detoxification of hydrogen peroxide
A	0062151	cellular_component	catalase complex
A	0070062	cellular_component	extracellular exosome
A	0070542	biological_process	response to fatty acid
A	0071363	biological_process	cellular response to growth factor stimulus
A	0072722	biological_process	response to amitrole
A	0080184	biological_process	response to phenylpropanoid
A	1904813	cellular_component	ficolin-1-rich granule lumen
B	0000302	biological_process	response to reactive oxygen species
B	0001649	biological_process	osteoblast differentiation
B	0001657	biological_process	ureteric bud development
B	0001666	biological_process	response to hypoxia
B	0001822	biological_process	kidney development
B	0004046	molecular_function	aminoacylase activity
B	0004096	molecular_function	catalase activity
B	0004601	molecular_function	peroxidase activity
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005777	cellular_component	peroxisome
B	0005778	cellular_component	peroxisomal membrane
B	0005782	cellular_component	peroxisomal matrix
B	0005829	cellular_component	cytosol
B	0005925	cellular_component	focal adhesion
B	0006641	biological_process	triglyceride metabolic process
B	0006979	biological_process	response to oxidative stress
B	0008203	biological_process	cholesterol metabolic process
B	0009060	biological_process	aerobic respiration
B	0009410	biological_process	response to xenobiotic stimulus
B	0009411	biological_process	response to UV
B	0009636	biological_process	response to toxic substance
B	0009642	biological_process	response to light intensity
B	0009650	biological_process	UV protection
B	0010193	biological_process	response to ozone
B	0010288	biological_process	response to lead ion
B	0014823	biological_process	response to activity
B	0014854	biological_process	response to inactivity
B	0016020	cellular_component	membrane
B	0016209	molecular_function	antioxidant activity
B	0016684	molecular_function	oxidoreductase activity, acting on peroxide as acceptor
B	0019899	molecular_function	enzyme binding
B	0020027	biological_process	hemoglobin metabolic process
B	0020037	molecular_function	heme binding
B	0032355	biological_process	response to estradiol
B	0032868	biological_process	response to insulin
B	0032991	cellular_component	protein-containing complex
B	0033189	biological_process	response to vitamin A
B	0033197	biological_process	response to vitamin E
B	0033591	biological_process	response to L-ascorbic acid
B	0034774	cellular_component	secretory granule lumen
B	0042542	biological_process	response to hydrogen peroxide
B	0042744	biological_process	hydrogen peroxide catabolic process
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0043066	biological_process	negative regulation of apoptotic process
B	0043231	cellular_component	intracellular membrane-bounded organelle
B	0045471	biological_process	response to ethanol
B	0046686	biological_process	response to cadmium ion
B	0046872	molecular_function	metal ion binding
B	0050661	molecular_function	NADP binding
B	0051781	biological_process	positive regulation of cell division
B	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B	0055093	biological_process	response to hyperoxia
B	0061692	biological_process	cellular detoxification of hydrogen peroxide
B	0062151	cellular_component	catalase complex
B	0070062	cellular_component	extracellular exosome
B	0070542	biological_process	response to fatty acid
B	0071363	biological_process	cellular response to growth factor stimulus
B	0072722	biological_process	response to amitrole
B	0080184	biological_process	response to phenylpropanoid
B	1904813	cellular_component	ficolin-1-rich granule lumen
C	0000302	biological_process	response to reactive oxygen species
C	0001649	biological_process	osteoblast differentiation
C	0001657	biological_process	ureteric bud development
C	0001666	biological_process	response to hypoxia
C	0001822	biological_process	kidney development
C	0004046	molecular_function	aminoacylase activity
C	0004096	molecular_function	catalase activity
C	0004601	molecular_function	peroxidase activity
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005777	cellular_component	peroxisome
C	0005778	cellular_component	peroxisomal membrane
C	0005782	cellular_component	peroxisomal matrix
C	0005829	cellular_component	cytosol
C	0005925	cellular_component	focal adhesion
C	0006641	biological_process	triglyceride metabolic process
C	0006979	biological_process	response to oxidative stress
C	0008203	biological_process	cholesterol metabolic process
C	0009060	biological_process	aerobic respiration
C	0009410	biological_process	response to xenobiotic stimulus
C	0009411	biological_process	response to UV
C	0009636	biological_process	response to toxic substance
C	0009642	biological_process	response to light intensity
C	0009650	biological_process	UV protection
C	0010193	biological_process	response to ozone
C	0010288	biological_process	response to lead ion
C	0014823	biological_process	response to activity
C	0014854	biological_process	response to inactivity
C	0016020	cellular_component	membrane
C	0016209	molecular_function	antioxidant activity
C	0016684	molecular_function	oxidoreductase activity, acting on peroxide as acceptor
C	0019899	molecular_function	enzyme binding
C	0020027	biological_process	hemoglobin metabolic process
C	0020037	molecular_function	heme binding
C	0032355	biological_process	response to estradiol
C	0032868	biological_process	response to insulin
C	0032991	cellular_component	protein-containing complex
C	0033189	biological_process	response to vitamin A
C	0033197	biological_process	response to vitamin E
C	0033591	biological_process	response to L-ascorbic acid
C	0034774	cellular_component	secretory granule lumen
C	0042542	biological_process	response to hydrogen peroxide
C	0042744	biological_process	hydrogen peroxide catabolic process
C	0042802	molecular_function	identical protein binding
C	0042803	molecular_function	protein homodimerization activity
C	0043066	biological_process	negative regulation of apoptotic process
C	0043231	cellular_component	intracellular membrane-bounded organelle
C	0045471	biological_process	response to ethanol
C	0046686	biological_process	response to cadmium ion
C	0046872	molecular_function	metal ion binding
C	0050661	molecular_function	NADP binding
C	0051781	biological_process	positive regulation of cell division
C	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C	0055093	biological_process	response to hyperoxia
C	0061692	biological_process	cellular detoxification of hydrogen peroxide
C	0062151	cellular_component	catalase complex
C	0070062	cellular_component	extracellular exosome
C	0070542	biological_process	response to fatty acid
C	0071363	biological_process	cellular response to growth factor stimulus
C	0072722	biological_process	response to amitrole
C	0080184	biological_process	response to phenylpropanoid
C	1904813	cellular_component	ficolin-1-rich granule lumen
D	0000302	biological_process	response to reactive oxygen species
D	0001649	biological_process	osteoblast differentiation
D	0001657	biological_process	ureteric bud development
D	0001666	biological_process	response to hypoxia
D	0001822	biological_process	kidney development
D	0004046	molecular_function	aminoacylase activity
D	0004096	molecular_function	catalase activity
D	0004601	molecular_function	peroxidase activity
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005777	cellular_component	peroxisome
D	0005778	cellular_component	peroxisomal membrane
D	0005782	cellular_component	peroxisomal matrix
D	0005829	cellular_component	cytosol
D	0005925	cellular_component	focal adhesion
D	0006641	biological_process	triglyceride metabolic process
D	0006979	biological_process	response to oxidative stress
D	0008203	biological_process	cholesterol metabolic process
D	0009060	biological_process	aerobic respiration
D	0009410	biological_process	response to xenobiotic stimulus
D	0009411	biological_process	response to UV
D	0009636	biological_process	response to toxic substance
D	0009642	biological_process	response to light intensity
D	0009650	biological_process	UV protection
D	0010193	biological_process	response to ozone
D	0010288	biological_process	response to lead ion
D	0014823	biological_process	response to activity
D	0014854	biological_process	response to inactivity
D	0016020	cellular_component	membrane
D	0016209	molecular_function	antioxidant activity
D	0016684	molecular_function	oxidoreductase activity, acting on peroxide as acceptor
D	0019899	molecular_function	enzyme binding
D	0020027	biological_process	hemoglobin metabolic process
D	0020037	molecular_function	heme binding
D	0032355	biological_process	response to estradiol
D	0032868	biological_process	response to insulin
D	0032991	cellular_component	protein-containing complex
D	0033189	biological_process	response to vitamin A
D	0033197	biological_process	response to vitamin E
D	0033591	biological_process	response to L-ascorbic acid
D	0034774	cellular_component	secretory granule lumen
D	0042542	biological_process	response to hydrogen peroxide
D	0042744	biological_process	hydrogen peroxide catabolic process
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0043066	biological_process	negative regulation of apoptotic process
D	0043231	cellular_component	intracellular membrane-bounded organelle
D	0045471	biological_process	response to ethanol
D	0046686	biological_process	response to cadmium ion
D	0046872	molecular_function	metal ion binding
D	0050661	molecular_function	NADP binding
D	0051781	biological_process	positive regulation of cell division
D	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
D	0055093	biological_process	response to hyperoxia
D	0061692	biological_process	cellular detoxification of hydrogen peroxide
D	0062151	cellular_component	catalase complex
D	0070062	cellular_component	extracellular exosome
D	0070542	biological_process	response to fatty acid
D	0071363	biological_process	cellular response to growth factor stimulus
D	0072722	biological_process	response to amitrole
D	0080184	biological_process	response to phenylpropanoid
D	1904813	cellular_component	ficolin-1-rich granule lumen

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT A 5000

Chain	Residue
A	HOH5375
A	HOH5465
A	HOH5469
A	HOH5493

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACT C 5001

Chain	Residue
C	ARG127
C	HOH5345
C	HOH5490

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT B 5002

Chain	Residue
B	HOH5493
B	HOH5535
B	HOH5372
B	HOH5479

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT D 5003

Chain	Residue
D	HIS466
D	HOH5454
D	HOH5522
D	HOH5553

---

site_id	AC5
Number of Residues	26
Details	BINDING SITE FOR RESIDUE HEM A 3000

Chain	Residue
A	ARG72
A	VAL73
A	VAL74
A	HIS75
A	ARG112
A	GLY131
A	VAL146
A	GLY147
A	ASN148
A	PRO158
A	PHE161
A	GLY216
A	SER217
A	LEU299
A	PHE334
A	MET350
A	ARG354
A	TYR358
A	THR361
A	HIS362
A	ARG365
A	HOH5001
A	HOH5006
A	HOH5076
C	MET61
C	ASP65

---

site_id	AC6
Number of Residues	22
Details	BINDING SITE FOR RESIDUE NDP A 4000

Chain	Residue
A	PRO151
A	HIS194
A	PHE198
A	SER201
A	ARG203
A	ASN213
A	HIS235
A	LYS237
A	VAL302
A	TRP303
A	PRO304
A	HIS305
A	GLN442
A	PHE446
A	VAL450
A	HOH5129
A	HOH5235
A	HOH5266
A	HOH5280
A	HOH5344
A	HOH5408
A	HOH5528

---

site_id	AC7
Number of Residues	25
Details	BINDING SITE FOR RESIDUE HEM B 3001

Chain	Residue
B	ARG72
B	VAL73
B	VAL74
B	HIS75
B	ARG112
B	GLY131
B	VAL146
B	GLY147
B	ASN148
B	PRO158
B	PHE161
B	GLY216
B	SER217
B	PHE334
B	MET350
B	ARG354
B	TYR358
B	THR361
B	HIS362
B	ARG365
B	HOH5003
B	HOH5018
B	HOH5058
D	MET61
D	ASP65

---

site_id	AC8
Number of Residues	26
Details	BINDING SITE FOR RESIDUE HEM C 3002

Chain	Residue
C	PRO158
C	PHE161
C	GLY216
C	SER217
C	LEU299
C	PHE334
C	MET350
C	ARG354
C	TYR358
C	THR361
C	HIS362
C	ARG365
C	HOH5003
C	HOH5018
C	HOH5065
A	MET61
A	ASP65
C	ARG72
C	VAL73
C	VAL74
C	HIS75
C	ARG112
C	GLY131
C	VAL146
C	GLY147
C	ASN148

---

site_id	AC9
Number of Residues	24
Details	BINDING SITE FOR RESIDUE NDP C 4001

Chain	Residue
C	PRO151
C	HIS194
C	PHE198
C	SER201
C	ARG203
C	ASN213
C	HIS235
C	LYS237
C	VAL302
C	TRP303
C	PRO304
C	HIS305
C	LYS306
C	GLN442
C	PHE446
C	VAL450
C	HOH5103
C	HOH5262
C	HOH5293
C	HOH5308
C	HOH5330
C	HOH5336
C	HOH5385
C	HOH5508

---

site_id	BC1
Number of Residues	25
Details	BINDING SITE FOR RESIDUE HEM D 3003

Chain	Residue
B	MET61
B	ASP65
D	ARG72
D	VAL73
D	VAL74
D	HIS75
D	ARG112
D	GLY131
D	VAL146
D	GLY147
D	ASN148
D	PRO158
D	PHE161
D	GLY216
D	SER217
D	PHE334
D	MET350
D	ARG354
D	TYR358
D	THR361
D	HIS362
D	ARG365
D	HOH5004
D	HOH5007
D	HOH5057

---

Functional Information from PROSITE/UniProt

site_id	PS00437
Number of Residues	9
Details	CATALASE_1 Catalase proximal heme-ligand signature. RLFAYpDTH

Chain	Residue	Details
A	ARG354-HIS362

---

site_id	PS00438
Number of Residues	17
Details	CATALASE_2 Catalase proximal active site signature. FdReripERvvHakGAG

Chain	Residue	Details
A	PHE64-GLY80

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: ACT_SITE => ECO:0000305|PubMed:10656833

Chain	Residue	Details
A	HIS75
A	ASN148
B	HIS75
B	ASN148
C	HIS75
C	ASN148
D	HIS75
D	ASN148

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	BINDING: BINDING => ECO:0000269|PubMed:10656833, ECO:0007744|PDB:1DGB, ECO:0007744|PDB:1DGF, ECO:0007744|PDB:1DGG, ECO:0007744|PDB:1DGH

Chain	Residue	Details
A	HIS194
B	ASN213
B	TRP303
B	HIS305
C	HIS194
C	SER201
C	ARG203
C	ASN213
C	TRP303
C	HIS305
D	HIS194
A	SER201
D	SER201
D	ARG203
D	ASN213
D	TRP303
D	HIS305
A	ARG203
A	ASN213
A	TRP303
A	HIS305
B	HIS194
B	SER201
B	ARG203

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:10656833, ECO:0007744|PDB:1DGB, ECO:0007744|PDB:1DGF, ECO:0007744|PDB:1DGH

Chain	Residue	Details
A	LYS237
B	LYS237
C	LYS237
D	LYS237

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:10656833, ECO:0007744|PDB:1DGF

Chain	Residue	Details
A	LYS306
B	LYS306
C	LYS306
D	LYS306

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	BINDING: axial binding residue => ECO:0000269|PubMed:10656833, ECO:0000269|PubMed:10666617, ECO:0007744|PDB:1DGB, ECO:0007744|PDB:1DGF, ECO:0007744|PDB:1DGG, ECO:0007744|PDB:1DGH, ECO:0007744|PDB:1F4J, ECO:0007744|PDB:1QQW

Chain	Residue	Details
A	TYR358
B	TYR358
C	TYR358
D	TYR358

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	SER9
A	SER422
B	SER9
B	SER422
C	SER9
C	SER422
D	SER9
D	SER422

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P24270

Chain	Residue	Details
A	LYS221
B	LYS221
C	LYS221
D	LYS221

---

site_id	SWS_FT_FI8
Number of Residues	8
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P24270

Chain	Residue	Details
A	LYS233
A	LYS499
B	LYS233
B	LYS499
C	LYS233
C	LYS499
D	LYS233
D	LYS499

---

site_id	SWS_FT_FI9
Number of Residues	8
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P24270

Chain	Residue	Details
A	LYS306
A	LYS480
B	LYS306
B	LYS480
C	LYS306
C	LYS480
D	LYS306
D	LYS480

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P24270

Chain	Residue	Details
A	SER417
B	SER417
C	SER417
D	SER417

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1iph

Chain	Residue	Details
A	HIS75
A	ASN148
A	SER114

---

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1iph

Chain	Residue	Details
B	HIS75
B	ASN148
B	SER114

---

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1iph

Chain	Residue	Details
C	HIS75
C	ASN148
C	SER114

---

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1iph

Chain	Residue	Details
D	HIS75
D	ASN148
D	SER114

---