1DFJ

RIBONUCLEASE INHIBITOR COMPLEXED WITH RIBONUCLEASE A

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0003676	molecular_function	nucleic acid binding
E	0004518	molecular_function	nuclease activity
E	0004519	molecular_function	endonuclease activity
E	0004522	molecular_function	ribonuclease A activity
E	0004540	molecular_function	RNA nuclease activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0016787	molecular_function	hydrolase activity
E	0016829	molecular_function	lyase activity
E	0050830	biological_process	defense response to Gram-positive bacterium
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005737	cellular_component	cytoplasm
I	0005886	cellular_component	plasma membrane
I	0008428	molecular_function	ribonuclease inhibitor activity
I	0016477	biological_process	cell migration
I	0030027	cellular_component	lamellipodium
I	0032311	cellular_component	angiogenin-PRI complex
I	0034315	biological_process	regulation of Arp2/3 complex-mediated actin nucleation
I	0045765	biological_process	regulation of angiogenesis

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 E 1001

Chain	Residue
E	GLN11
E	HIS12
E	LYS41
E	HIS119
E	PHE120
I	ASP431

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Functional Information from PROSITE/UniProt

site_id	PS00127
Number of Residues	7
Details	RNASE_PANCREATIC Pancreatic ribonuclease family signature. CKpvNTF

Chain	Residue	Details
E	CYS40-PHE46

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton donor"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (Glc) (glycation) lysine; in vitro","evidences":[{"source":"PubMed","id":"4030761","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine; partial","featureId":"CAR_000006","evidences":[{"source":"PubMed","id":"19358553","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	28
Details	Repeat: {"description":"LRR 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	27
Details	Repeat: {"description":"LRR 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	28
Details	Repeat: {"description":"LRR 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	27
Details	Repeat: {"description":"LRR 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	28
Details	Repeat: {"description":"LRR 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	27
Details	Repeat: {"description":"LRR 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	28
Details	Repeat: {"description":"LRR 7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	27
Details	Repeat: {"description":"LRR 8"}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	28
Details	Repeat: {"description":"LRR 9"}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	27
Details	Repeat: {"description":"LRR 10"}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	28
Details	Repeat: {"description":"LRR 11"}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	27
Details	Repeat: {"description":"LRR 12"}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	28
Details	Repeat: {"description":"LRR 13"}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	27
Details	Repeat: {"description":"LRR 14"}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	28
Details	Repeat: {"description":"LRR 15"}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	1
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"3219361","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P13489","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1rbn

Chain	Residue	Details
E	PHE120
E	HIS119
E	HIS12
E	LYS41

---

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1rbn

Chain	Residue	Details
E	HIS119
E	HIS12
E	LYS41

---

site_id	MCSA1
Number of Residues	5
Details	M-CSA 164

Chain

Residue

Details

---