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1DFC

CRYSTAL STRUCTURE OF HUMAN FASCIN, AN ACTIN-CROSSLINKING PROTEIN

Functional Information from GO Data
ChainGOidnamespacecontents
A0001725cellular_componentstress fiber
A0001726cellular_componentruffle
A0002102cellular_componentpodosome
A0003723molecular_functionRNA binding
A0003779molecular_functionactin binding
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005902cellular_componentmicrovillus
A0005911cellular_componentcell-cell junction
A0005938cellular_componentcell cortex
A0007015biological_processactin filament organization
A0007043biological_processcell-cell junction assembly
A0007163biological_processestablishment or maintenance of cell polarity
A0008144molecular_functionobsolete drug binding
A0010592biological_processpositive regulation of lamellipodium assembly
A0015629cellular_componentactin cytoskeleton
A0016477biological_processcell migration
A0030027cellular_componentlamellipodium
A0030035biological_processmicrospike assembly
A0030036biological_processactin cytoskeleton organization
A0030046biological_processparallel actin filament bundle assembly
A0030175cellular_componentfilopodium
A0030426cellular_componentgrowth cone
A0030674molecular_functionprotein-macromolecule adaptor activity
A0031253cellular_componentcell projection membrane
A0032534biological_processregulation of microvillus assembly
A0032956biological_processregulation of actin cytoskeleton organization
A0035089biological_processestablishment of apical/basal cell polarity
A0042995cellular_componentcell projection
A0044393cellular_componentmicrospike
A0045296molecular_functioncadherin binding
A0048870biological_processcell motility
A0051015molecular_functionactin filament binding
A0051017biological_processactin filament bundle assembly
A0051491biological_processpositive regulation of filopodium assembly
A0070062cellular_componentextracellular exosome
A0070161cellular_componentanchoring junction
A0071803biological_processpositive regulation of podosome assembly
A0090091biological_processpositive regulation of extracellular matrix disassembly
B0001725cellular_componentstress fiber
B0001726cellular_componentruffle
B0002102cellular_componentpodosome
B0003723molecular_functionRNA binding
B0003779molecular_functionactin binding
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005902cellular_componentmicrovillus
B0005911cellular_componentcell-cell junction
B0005938cellular_componentcell cortex
B0007015biological_processactin filament organization
B0007043biological_processcell-cell junction assembly
B0007163biological_processestablishment or maintenance of cell polarity
B0008144molecular_functionobsolete drug binding
B0010592biological_processpositive regulation of lamellipodium assembly
B0015629cellular_componentactin cytoskeleton
B0016477biological_processcell migration
B0030027cellular_componentlamellipodium
B0030035biological_processmicrospike assembly
B0030036biological_processactin cytoskeleton organization
B0030046biological_processparallel actin filament bundle assembly
B0030175cellular_componentfilopodium
B0030426cellular_componentgrowth cone
B0030674molecular_functionprotein-macromolecule adaptor activity
B0031253cellular_componentcell projection membrane
B0032534biological_processregulation of microvillus assembly
B0032956biological_processregulation of actin cytoskeleton organization
B0035089biological_processestablishment of apical/basal cell polarity
B0042995cellular_componentcell projection
B0044393cellular_componentmicrospike
B0045296molecular_functioncadherin binding
B0048870biological_processcell motility
B0051015molecular_functionactin filament binding
B0051017biological_processactin filament bundle assembly
B0051491biological_processpositive regulation of filopodium assembly
B0070062cellular_componentextracellular exosome
B0070161cellular_componentanchoring junction
B0071803biological_processpositive regulation of podosome assembly
B0090091biological_processpositive regulation of extracellular matrix disassembly
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: N-acetylthreonine => ECO:0000269|Ref.9, ECO:0007744|PubMed:22223895
ChainResidueDetails
ATHR1002
BTHR2002

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648
ChainResidueDetails
ASER1038
BSER2038

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8999969, ECO:0000305|PubMed:22155786
ChainResidueDetails
ASER1039
BSER2039

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q61553
ChainResidueDetails
ALYS1074
BLYS2074

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER1127
ASER1234
BSER2127
BSER2234

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ATHR1239
BTHR2239

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P85845
ChainResidueDetails
ATHR1403
BTHR2403

site_idSWS_FT_FI8
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25218447
ChainResidueDetails
ALYS1399
BLYS2399

219140

PDB entries from 2024-05-01

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