1DEU
CRYSTAL STRUCTURE OF HUMAN PROCATHEPSIN X: A CYSTEINE PROTEASE WITH THE PROREGION COVALENTLY LINKED TO THE ACTIVE SITE CYSTEINE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002003 | biological_process | angiotensin maturation |
| A | 0004180 | molecular_function | carboxypeptidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005764 | cellular_component | lysosome |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005788 | cellular_component | endoplasmic reticulum lumen |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005938 | cellular_component | cell cortex |
| A | 0006508 | biological_process | proteolysis |
| A | 0008234 | molecular_function | cysteine-type peptidase activity |
| A | 0009986 | cellular_component | cell surface |
| A | 0010757 | biological_process | negative regulation of plasminogen activation |
| A | 0016807 | molecular_function | cysteine-type carboxypeptidase activity |
| A | 0030134 | cellular_component | COPII-coated ER to Golgi transport vesicle |
| A | 0030426 | cellular_component | growth cone |
| A | 0031012 | cellular_component | extracellular matrix |
| A | 0031410 | cellular_component | cytoplasmic vesicle |
| A | 0033116 | cellular_component | endoplasmic reticulum-Golgi intermediate compartment membrane |
| A | 0035580 | cellular_component | specific granule lumen |
| A | 0060441 | biological_process | epithelial tube branching involved in lung morphogenesis |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 1904813 | cellular_component | ficolin-1-rich granule lumen |
| B | 0002003 | biological_process | angiotensin maturation |
| B | 0004180 | molecular_function | carboxypeptidase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005764 | cellular_component | lysosome |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0005788 | cellular_component | endoplasmic reticulum lumen |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0005938 | cellular_component | cell cortex |
| B | 0006508 | biological_process | proteolysis |
| B | 0008234 | molecular_function | cysteine-type peptidase activity |
| B | 0009986 | cellular_component | cell surface |
| B | 0010757 | biological_process | negative regulation of plasminogen activation |
| B | 0016807 | molecular_function | cysteine-type carboxypeptidase activity |
| B | 0030134 | cellular_component | COPII-coated ER to Golgi transport vesicle |
| B | 0030426 | cellular_component | growth cone |
| B | 0031012 | cellular_component | extracellular matrix |
| B | 0031410 | cellular_component | cytoplasmic vesicle |
| B | 0033116 | cellular_component | endoplasmic reticulum-Golgi intermediate compartment membrane |
| B | 0035580 | cellular_component | specific granule lumen |
| B | 0060441 | biological_process | epithelial tube branching involved in lung morphogenesis |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 1904813 | cellular_component | ficolin-1-rich granule lumen |
Functional Information from PROSITE/UniProt
| site_id | PS00640 |
| Number of Residues | 20 |
| Details | THIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. YWIvRNSWgepWGerGWLrI |
| Chain | Residue | Details |
| A | TYR195-ILE214 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"10656802","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"10745011","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1pad |
| Chain | Residue | Details |
| A | CYS31 | |
| A | ASN200 | |
| A | HIS180 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1pad |
| Chain | Residue | Details |
| B | CYS31 | |
| B | ASN200 | |
| B | HIS180 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1pad |
| Chain | Residue | Details |
| A | GLN22 | |
| A | CYS31 | |
| A | HIS180 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1pad |
| Chain | Residue | Details |
| B | GLN22 | |
| B | CYS31 | |
| B | HIS180 |
| site_id | CSA5 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1pad |
| Chain | Residue | Details |
| A | GLN22 | |
| A | ASN200 | |
| A | HIS180 |
| site_id | CSA6 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1pad |
| Chain | Residue | Details |
| B | GLN22 | |
| B | ASN200 | |
| B | HIS180 |
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 953 |
| Chain | Residue | Details |
| A | GLN22 | electrostatic stabiliser |
| A | CYS31 | covalent catalysis, proton shuttle (general acid/base) |
| A | HIS180 | proton shuttle (general acid/base) |
| A | ASN200 | electrostatic stabiliser, modifies pKa |
| site_id | MCSA2 |
| Number of Residues | 4 |
| Details | M-CSA 953 |
| Chain | Residue | Details |
| B | GLN22 | electrostatic stabiliser |
| B | CYS31 | covalent catalysis, proton shuttle (general acid/base) |
| B | HIS180 | proton shuttle (general acid/base) |
| B | ASN200 | electrostatic stabiliser, modifies pKa |
