Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0004252 | molecular_function | serine-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| C | 0004252 | molecular_function | serine-type endopeptidase activity |
| C | 0006508 | biological_process | proteolysis |
| D | 0004252 | molecular_function | serine-type endopeptidase activity |
| D | 0006508 | biological_process | proteolysis |
Functional Information from PROSITE/UniProt
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC |
| Chain | Residue | Details |
| A | LEU599-CYS604 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 908 |
| Details | Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Active site: {"description":"Charge relay system"} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Site: {"description":"Cleavage; by plasminogen activator"} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"9201958","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | a catalytic site defined by CSA, PubMed 10656799 |
| Chain | Residue | Details |
| A | HIS603 | |
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 425 |
| Chain | Residue | Details |
| A | HIS603 | proton shuttle (general acid/base) |
| A | ASP646 | electrostatic stabiliser, modifies pKa |
| A | ALA741 | covalent catalysis, proton shuttle (general acid/base) |
| A | GLY742 | electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | 4 |
| Details | M-CSA 425 |
| Chain | Residue | Details |
| B | HIS603 | proton shuttle (general acid/base) |
| B | ASP646 | electrostatic stabiliser, modifies pKa |
| B | ALA741 | covalent catalysis, proton shuttle (general acid/base) |
| B | GLY742 | electrostatic stabiliser |
| site_id | MCSA3 |
| Number of Residues | 4 |
| Details | M-CSA 425 |
| Chain | Residue | Details |
| C | HIS603 | proton shuttle (general acid/base) |
| C | ASP646 | electrostatic stabiliser, modifies pKa |
| C | ALA741 | covalent catalysis, proton shuttle (general acid/base) |
| C | GLY742 | electrostatic stabiliser |
| site_id | MCSA4 |
| Number of Residues | 4 |
| Details | M-CSA 425 |
| Chain | Residue | Details |
| D | HIS603 | proton shuttle (general acid/base) |
| D | ASP646 | electrostatic stabiliser, modifies pKa |
| D | ALA741 | covalent catalysis, proton shuttle (general acid/base) |
| D | GLY742 | electrostatic stabiliser |
