1DCO

DCOH, A BIFUNCTIONAL PROTEIN-BINDING TRANSCRIPTIONAL COACTIVATOR

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003713	molecular_function	transcription coactivator activity
A	0004505	molecular_function	phenylalanine 4-monooxygenase activity
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0006558	biological_process	L-phenylalanine metabolic process
A	0006729	biological_process	tetrahydrobiopterin biosynthetic process
A	0008124	molecular_function	4-alpha-hydroxytetrahydrobiopterin dehydratase activity
A	0008150	biological_process	biological_process
A	0009072	biological_process	aromatic amino acid metabolic process
A	0016829	molecular_function	lyase activity
A	0019293	biological_process	tyrosine biosynthetic process, by oxidation of phenylalanine
A	0042802	molecular_function	identical protein binding
A	0043393	biological_process	regulation of protein binding
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	1902221	biological_process	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process
B	0003713	molecular_function	transcription coactivator activity
B	0004505	molecular_function	phenylalanine 4-monooxygenase activity
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0006558	biological_process	L-phenylalanine metabolic process
B	0006729	biological_process	tetrahydrobiopterin biosynthetic process
B	0008124	molecular_function	4-alpha-hydroxytetrahydrobiopterin dehydratase activity
B	0008150	biological_process	biological_process
B	0009072	biological_process	aromatic amino acid metabolic process
B	0016829	molecular_function	lyase activity
B	0019293	biological_process	tyrosine biosynthetic process, by oxidation of phenylalanine
B	0042802	molecular_function	identical protein binding
B	0043393	biological_process	regulation of protein binding
B	0045893	biological_process	positive regulation of DNA-templated transcription
B	1902221	biological_process	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process
C	0003713	molecular_function	transcription coactivator activity
C	0004505	molecular_function	phenylalanine 4-monooxygenase activity
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0006558	biological_process	L-phenylalanine metabolic process
C	0006729	biological_process	tetrahydrobiopterin biosynthetic process
C	0008124	molecular_function	4-alpha-hydroxytetrahydrobiopterin dehydratase activity
C	0008150	biological_process	biological_process
C	0009072	biological_process	aromatic amino acid metabolic process
C	0016829	molecular_function	lyase activity
C	0019293	biological_process	tyrosine biosynthetic process, by oxidation of phenylalanine
C	0042802	molecular_function	identical protein binding
C	0043393	biological_process	regulation of protein binding
C	0045893	biological_process	positive regulation of DNA-templated transcription
C	1902221	biological_process	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process
D	0003713	molecular_function	transcription coactivator activity
D	0004505	molecular_function	phenylalanine 4-monooxygenase activity
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0006558	biological_process	L-phenylalanine metabolic process
D	0006729	biological_process	tetrahydrobiopterin biosynthetic process
D	0008124	molecular_function	4-alpha-hydroxytetrahydrobiopterin dehydratase activity
D	0008150	biological_process	biological_process
D	0009072	biological_process	aromatic amino acid metabolic process
D	0016829	molecular_function	lyase activity
D	0019293	biological_process	tyrosine biosynthetic process, by oxidation of phenylalanine
D	0042802	molecular_function	identical protein binding
D	0043393	biological_process	regulation of protein binding
D	0045893	biological_process	positive regulation of DNA-templated transcription
D	1902221	biological_process	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process
E	0003713	molecular_function	transcription coactivator activity
E	0004505	molecular_function	phenylalanine 4-monooxygenase activity
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0006558	biological_process	L-phenylalanine metabolic process
E	0006729	biological_process	tetrahydrobiopterin biosynthetic process
E	0008124	molecular_function	4-alpha-hydroxytetrahydrobiopterin dehydratase activity
E	0008150	biological_process	biological_process
E	0009072	biological_process	aromatic amino acid metabolic process
E	0016829	molecular_function	lyase activity
E	0019293	biological_process	tyrosine biosynthetic process, by oxidation of phenylalanine
E	0042802	molecular_function	identical protein binding
E	0043393	biological_process	regulation of protein binding
E	0045893	biological_process	positive regulation of DNA-templated transcription
E	1902221	biological_process	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process
F	0003713	molecular_function	transcription coactivator activity
F	0004505	molecular_function	phenylalanine 4-monooxygenase activity
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0006558	biological_process	L-phenylalanine metabolic process
F	0006729	biological_process	tetrahydrobiopterin biosynthetic process
F	0008124	molecular_function	4-alpha-hydroxytetrahydrobiopterin dehydratase activity
F	0008150	biological_process	biological_process
F	0009072	biological_process	aromatic amino acid metabolic process
F	0016829	molecular_function	lyase activity
F	0019293	biological_process	tyrosine biosynthetic process, by oxidation of phenylalanine
F	0042802	molecular_function	identical protein binding
F	0043393	biological_process	regulation of protein binding
F	0045893	biological_process	positive regulation of DNA-templated transcription
F	1902221	biological_process	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process
G	0003713	molecular_function	transcription coactivator activity
G	0004505	molecular_function	phenylalanine 4-monooxygenase activity
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0006558	biological_process	L-phenylalanine metabolic process
G	0006729	biological_process	tetrahydrobiopterin biosynthetic process
G	0008124	molecular_function	4-alpha-hydroxytetrahydrobiopterin dehydratase activity
G	0008150	biological_process	biological_process
G	0009072	biological_process	aromatic amino acid metabolic process
G	0016829	molecular_function	lyase activity
G	0019293	biological_process	tyrosine biosynthetic process, by oxidation of phenylalanine
G	0042802	molecular_function	identical protein binding
G	0043393	biological_process	regulation of protein binding
G	0045893	biological_process	positive regulation of DNA-templated transcription
G	1902221	biological_process	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process
H	0003713	molecular_function	transcription coactivator activity
H	0004505	molecular_function	phenylalanine 4-monooxygenase activity
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0006558	biological_process	L-phenylalanine metabolic process
H	0006729	biological_process	tetrahydrobiopterin biosynthetic process
H	0008124	molecular_function	4-alpha-hydroxytetrahydrobiopterin dehydratase activity
H	0008150	biological_process	biological_process
H	0009072	biological_process	aromatic amino acid metabolic process
H	0016829	molecular_function	lyase activity
H	0019293	biological_process	tyrosine biosynthetic process, by oxidation of phenylalanine
H	0042802	molecular_function	identical protein binding
H	0043393	biological_process	regulation of protein binding
H	0045893	biological_process	positive regulation of DNA-templated transcription
H	1902221	biological_process	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	Binding site: {}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	6
Details	a catalytic site defined by CSA, PubMed 8897596, 9698371

Chain	Residue	Details
A	GLU58
A	HIS63
A	HIS62
A	HIS80
A	HIS80
A	GLU81

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site_id	MCSA1
Number of Residues	6
Details	M-CSA 73

Chain	Residue	Details
A	GLU58	electrostatic stabiliser, hydrogen bond acceptor, proton acceptor, proton donor
A	HIS62	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
A	HIS63	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay
A	HIS80	electrostatic stabiliser, hydrogen bond donor
A	GLU81	electrostatic stabiliser, hydrogen bond donor
A	ASP89	electrostatic stabiliser, hydrogen bond acceptor

---

site_id	MCSA2
Number of Residues	6
Details	M-CSA 73

Chain	Residue	Details
B	GLU58	electrostatic stabiliser, hydrogen bond acceptor, proton acceptor, proton donor
B	HIS62	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
B	HIS63	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay
B	HIS80	electrostatic stabiliser, hydrogen bond donor
B	GLU81	electrostatic stabiliser, hydrogen bond donor
B	ASP89	electrostatic stabiliser, hydrogen bond acceptor

---

site_id	MCSA3
Number of Residues	6
Details	M-CSA 73

Chain	Residue	Details
C	GLU58	electrostatic stabiliser, hydrogen bond acceptor, proton acceptor, proton donor
C	HIS62	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
C	HIS63	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay
C	HIS80	electrostatic stabiliser, hydrogen bond donor
C	GLU81	electrostatic stabiliser, hydrogen bond donor
C	ASP89	electrostatic stabiliser, hydrogen bond acceptor

---

site_id	MCSA4
Number of Residues	6
Details	M-CSA 73

Chain	Residue	Details
D	GLU58	electrostatic stabiliser, hydrogen bond acceptor, proton acceptor, proton donor
D	HIS62	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
D	HIS63	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay
D	HIS80	electrostatic stabiliser, hydrogen bond donor
D	GLU81	electrostatic stabiliser, hydrogen bond donor
D	ASP89	electrostatic stabiliser, hydrogen bond acceptor

---

site_id	MCSA5
Number of Residues	6
Details	M-CSA 73

Chain	Residue	Details
E	GLU58	electrostatic stabiliser, hydrogen bond acceptor, proton acceptor, proton donor
E	HIS62	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
E	HIS63	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay
E	HIS80	electrostatic stabiliser, hydrogen bond donor
E	GLU81	electrostatic stabiliser, hydrogen bond donor
E	ASP89	electrostatic stabiliser, hydrogen bond acceptor

---

site_id	MCSA6
Number of Residues	6
Details	M-CSA 73

Chain	Residue	Details
F	GLU58	electrostatic stabiliser, hydrogen bond acceptor, proton acceptor, proton donor
F	HIS62	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
F	HIS63	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay
F	HIS80	electrostatic stabiliser, hydrogen bond donor
F	GLU81	electrostatic stabiliser, hydrogen bond donor
F	ASP89	electrostatic stabiliser, hydrogen bond acceptor

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site_id	MCSA7
Number of Residues	6
Details	M-CSA 73

Chain	Residue	Details
G	GLU58	electrostatic stabiliser, hydrogen bond acceptor, proton acceptor, proton donor
G	HIS62	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
G	HIS63	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay
G	HIS80	electrostatic stabiliser, hydrogen bond donor
G	GLU81	electrostatic stabiliser, hydrogen bond donor
G	ASP89	electrostatic stabiliser, hydrogen bond acceptor

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site_id	MCSA8
Number of Residues	6
Details	M-CSA 73

Chain	Residue	Details
H	GLU58	electrostatic stabiliser, hydrogen bond acceptor, proton acceptor, proton donor
H	HIS62	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
H	HIS63	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay
H	HIS80	electrostatic stabiliser, hydrogen bond donor
H	GLU81	electrostatic stabiliser, hydrogen bond donor
H	ASP89	electrostatic stabiliser, hydrogen bond acceptor

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