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CRYSTAL STRUCTURE OF A BINARY COMPLEX OF PROTEIN KINASE CK2 (ALPHA-SUBUNIT) AND MG-GMPPNP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0004676 | molecular_function | 3-phosphoinositide-dependent protein kinase activity |
| A | 0004677 | molecular_function | DNA-dependent protein kinase activity |
| A | 0004679 | molecular_function | AMP-activated protein kinase activity |
| A | 0004694 | molecular_function | eukaryotic translation initiation factor 2alpha kinase activity |
| A | 0004711 | molecular_function | ribosomal protein S6 kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005829 | cellular_component | cytosol |
| A | 0005956 | cellular_component | protein kinase CK2 complex |
| A | 0006338 | biological_process | chromatin remodeling |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0006974 | biological_process | DNA damage response |
| A | 0035175 | molecular_function | histone H3S10 kinase activity |
| A | 0035402 | molecular_function | histone H3T11 kinase activity |
| A | 0035403 | molecular_function | histone H3T6 kinase activity |
| A | 0035979 | molecular_function | histone H2AXS139 kinase activity |
| A | 0044022 | molecular_function | histone H3S28 kinase activity |
| A | 0044023 | molecular_function | histone H4S1 kinase activity |
| A | 0044024 | molecular_function | histone H2AS1 kinase activity |
| A | 0044025 | molecular_function | histone H2BS14 kinase activity |
| A | 0051726 | biological_process | regulation of cell cycle |
| A | 0072354 | molecular_function | histone H3T3 kinase activity |
| A | 0072371 | molecular_function | histone H2AS121 kinase activity |
| A | 0072518 | molecular_function | Rho-dependent protein serine/threonine kinase activity |
| A | 0106310 | molecular_function | protein serine kinase activity |
| A | 0140823 | molecular_function | histone H2BS36 kinase activity |
| A | 0140855 | molecular_function | histone H3S57 kinase activity |
| A | 0140857 | molecular_function | histone H3T45 kinase activity |
| A | 1990244 | molecular_function | histone H2AT120 kinase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 341 |
| Chain | Residue |
| A | ASP175 |
| A | GNP340 |
| A | MG342 |
| A | HOH362 |
| A | HOH560 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 342 |
| Chain | Residue |
| A | HOH355 |
| A | ASN161 |
| A | ASP175 |
| A | GNP340 |
| A | MG341 |
| site_id | AC3 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE GNP A 340 |
| Chain | Residue |
| A | VAL45 |
| A | GLY46 |
| A | SER51 |
| A | VAL53 |
| A | ILE66 |
| A | LYS68 |
| A | VAL116 |
| A | LYS158 |
| A | HIS160 |
| A | ASN161 |
| A | MET163 |
| A | ILE174 |
| A | ASP175 |
| A | MG341 |
| A | MG342 |
| A | HOH350 |
| A | HOH351 |
| A | HOH352 |
| A | HOH353 |
| A | HOH355 |
| A | HOH362 |
| A | HOH455 |
| A | HOH524 |
| A | HOH560 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 24 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGRGKYSEVFeGinvnnnek..........CIIK |
| Chain | Residue | Details |
| A | VAL45-LYS68 |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ImHrDVKphNVMI |
| Chain | Residue | Details |
| A | ILE152-ILE164 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor |
| Chain | Residue | Details |
| A | ASP156 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | VAL45 | |
| A | LYS68 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | ASP156 | |
| A | HIS160 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | ASP156 | |
| A | LYS158 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | ASP156 | |
| A | LYS158 | |
| A | SER194 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | ASP156 | |
| A | ASN161 | |
| A | LYS158 |
