Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1DAO

COVALENT ADDUCT OF D-AMINO ACID OXIDASE FROM PIG KIDNEY WITH 3-METHYL-2-OXO-VALERIC ACID

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003884	molecular_function	D-amino-acid oxidase activity
A	0005737	cellular_component	cytoplasm
A	0005777	cellular_component	peroxisome
A	0005782	cellular_component	peroxisomal matrix
A	0006562	biological_process	proline catabolic process
A	0007586	biological_process	digestion
A	0016491	molecular_function	oxidoreductase activity
A	0019478	biological_process	D-amino acid catabolic process
A	0036088	biological_process	D-serine catabolic process
A	0042416	biological_process	dopamine biosynthetic process
A	0046416	biological_process	D-amino acid metabolic process
A	0048786	cellular_component	presynaptic active zone
A	0055130	biological_process	D-alanine catabolic process
A	0070945	biological_process	neutrophil-mediated killing of gram-negative bacterium
A	0071949	molecular_function	FAD binding
B	0003884	molecular_function	D-amino-acid oxidase activity
B	0005737	cellular_component	cytoplasm
B	0005777	cellular_component	peroxisome
B	0005782	cellular_component	peroxisomal matrix
B	0006562	biological_process	proline catabolic process
B	0007586	biological_process	digestion
B	0016491	molecular_function	oxidoreductase activity
B	0019478	biological_process	D-amino acid catabolic process
B	0036088	biological_process	D-serine catabolic process
B	0042416	biological_process	dopamine biosynthetic process
B	0046416	biological_process	D-amino acid metabolic process
B	0048786	cellular_component	presynaptic active zone
B	0055130	biological_process	D-alanine catabolic process
B	0070945	biological_process	neutrophil-mediated killing of gram-negative bacterium
B	0071949	molecular_function	FAD binding
C	0003884	molecular_function	D-amino-acid oxidase activity
C	0005737	cellular_component	cytoplasm
C	0005777	cellular_component	peroxisome
C	0005782	cellular_component	peroxisomal matrix
C	0006562	biological_process	proline catabolic process
C	0007586	biological_process	digestion
C	0016491	molecular_function	oxidoreductase activity
C	0019478	biological_process	D-amino acid catabolic process
C	0036088	biological_process	D-serine catabolic process
C	0042416	biological_process	dopamine biosynthetic process
C	0046416	biological_process	D-amino acid metabolic process
C	0048786	cellular_component	presynaptic active zone
C	0055130	biological_process	D-alanine catabolic process
C	0070945	biological_process	neutrophil-mediated killing of gram-negative bacterium
C	0071949	molecular_function	FAD binding
D	0003884	molecular_function	D-amino-acid oxidase activity
D	0005737	cellular_component	cytoplasm
D	0005777	cellular_component	peroxisome
D	0005782	cellular_component	peroxisomal matrix
D	0006562	biological_process	proline catabolic process
D	0007586	biological_process	digestion
D	0016491	molecular_function	oxidoreductase activity
D	0019478	biological_process	D-amino acid catabolic process
D	0036088	biological_process	D-serine catabolic process
D	0042416	biological_process	dopamine biosynthetic process
D	0046416	biological_process	D-amino acid metabolic process
D	0048786	cellular_component	presynaptic active zone
D	0055130	biological_process	D-alanine catabolic process
D	0070945	biological_process	neutrophil-mediated killing of gram-negative bacterium
D	0071949	molecular_function	FAD binding
E	0003884	molecular_function	D-amino-acid oxidase activity
E	0005737	cellular_component	cytoplasm
E	0005777	cellular_component	peroxisome
E	0005782	cellular_component	peroxisomal matrix
E	0006562	biological_process	proline catabolic process
E	0007586	biological_process	digestion
E	0016491	molecular_function	oxidoreductase activity
E	0019478	biological_process	D-amino acid catabolic process
E	0036088	biological_process	D-serine catabolic process
E	0042416	biological_process	dopamine biosynthetic process
E	0046416	biological_process	D-amino acid metabolic process
E	0048786	cellular_component	presynaptic active zone
E	0055130	biological_process	D-alanine catabolic process
E	0070945	biological_process	neutrophil-mediated killing of gram-negative bacterium
E	0071949	molecular_function	FAD binding
F	0003884	molecular_function	D-amino-acid oxidase activity
F	0005737	cellular_component	cytoplasm
F	0005777	cellular_component	peroxisome
F	0005782	cellular_component	peroxisomal matrix
F	0006562	biological_process	proline catabolic process
F	0007586	biological_process	digestion
F	0016491	molecular_function	oxidoreductase activity
F	0019478	biological_process	D-amino acid catabolic process
F	0036088	biological_process	D-serine catabolic process
F	0042416	biological_process	dopamine biosynthetic process
F	0046416	biological_process	D-amino acid metabolic process
F	0048786	cellular_component	presynaptic active zone
F	0055130	biological_process	D-alanine catabolic process
F	0070945	biological_process	neutrophil-mediated killing of gram-negative bacterium
F	0071949	molecular_function	FAD binding
G	0003884	molecular_function	D-amino-acid oxidase activity
G	0005737	cellular_component	cytoplasm
G	0005777	cellular_component	peroxisome
G	0005782	cellular_component	peroxisomal matrix
G	0006562	biological_process	proline catabolic process
G	0007586	biological_process	digestion
G	0016491	molecular_function	oxidoreductase activity
G	0019478	biological_process	D-amino acid catabolic process
G	0036088	biological_process	D-serine catabolic process
G	0042416	biological_process	dopamine biosynthetic process
G	0046416	biological_process	D-amino acid metabolic process
G	0048786	cellular_component	presynaptic active zone
G	0055130	biological_process	D-alanine catabolic process
G	0070945	biological_process	neutrophil-mediated killing of gram-negative bacterium
G	0071949	molecular_function	FAD binding
H	0003884	molecular_function	D-amino-acid oxidase activity
H	0005737	cellular_component	cytoplasm
H	0005777	cellular_component	peroxisome
H	0005782	cellular_component	peroxisomal matrix
H	0006562	biological_process	proline catabolic process
H	0007586	biological_process	digestion
H	0016491	molecular_function	oxidoreductase activity
H	0019478	biological_process	D-amino acid catabolic process
H	0036088	biological_process	D-serine catabolic process
H	0042416	biological_process	dopamine biosynthetic process
H	0046416	biological_process	D-amino acid metabolic process
H	0048786	cellular_component	presynaptic active zone
H	0055130	biological_process	D-alanine catabolic process
H	0070945	biological_process	neutrophil-mediated killing of gram-negative bacterium
H	0071949	molecular_function	FAD binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	31
Details	BINDING SITE FOR RESIDUE FAB A 348

Chain	Residue
A	ALA8
A	GLY9
A	VAL10
A	ILE11
A	ALA36
A	ASP37
A	ARG38
A	THR43
A	THR44
A	THR45
A	ALA48
A	ALA49
A	GLY50
A	LEU51
A	ARG162
A	LYS163
A	VAL164
A	CYS181
A	THR182
A	TRP185
A	TYR224
A	TYR228
A	ARG283
A	HIS311
A	GLY312
A	GLY313
A	TYR314
A	GLY315
A	LEU316
A	THR317
A	GLY7

site_id	AC2
Number of Residues	31
Details	BINDING SITE FOR RESIDUE FAB B 348

Chain	Residue
B	GLY7
B	ALA8
B	GLY9
B	VAL10
B	ILE11
B	ALA36
B	ASP37
B	ARG38
B	THR43
B	THR44
B	THR45
B	ALA48
B	ALA49
B	GLY50
B	LEU51
B	ARG162
B	LYS163
B	VAL164
B	CYS181
B	THR182
B	TRP185
B	TYR224
B	TYR228
B	ARG283
B	HIS311
B	GLY312
B	GLY313
B	TYR314
B	GLY315
B	LEU316
B	THR317

site_id	AC3
Number of Residues	31
Details	BINDING SITE FOR RESIDUE FAB C 348

Chain	Residue
C	LEU316
C	THR317
C	GLY7
C	ALA8
C	GLY9
C	VAL10
C	ILE11
C	ALA36
C	ASP37
C	ARG38
C	THR43
C	THR44
C	THR45
C	ALA48
C	ALA49
C	GLY50
C	LEU51
C	ARG162
C	LYS163
C	VAL164
C	CYS181
C	THR182
C	TRP185
C	TYR224
C	TYR228
C	ARG283
C	HIS311
C	GLY312
C	GLY313
C	TYR314
C	GLY315

site_id	AC4
Number of Residues	30
Details	BINDING SITE FOR RESIDUE FAB D 348

Chain	Residue
D	GLY7
D	ALA8
D	GLY9
D	VAL10
D	ILE11
D	ALA36
D	ASP37
D	ARG38
D	THR43
D	THR44
D	THR45
D	ALA48
D	ALA49
D	GLY50
D	LEU51
D	ARG162
D	VAL164
D	CYS181
D	THR182
D	TRP185
D	TYR224
D	TYR228
D	ARG283
D	HIS311
D	GLY312
D	GLY313
D	TYR314
D	GLY315
D	LEU316
D	THR317

site_id	AC5
Number of Residues	31
Details	BINDING SITE FOR RESIDUE FAB E 348

Chain	Residue
E	GLY7
E	ALA8
E	GLY9
E	VAL10
E	ILE11
E	ALA36
E	ASP37
E	ARG38
E	THR43
E	THR44
E	THR45
E	ALA48
E	ALA49
E	GLY50
E	LEU51
E	ARG162
E	LYS163
E	VAL164
E	CYS181
E	THR182
E	TRP185
E	TYR224
E	TYR228
E	ARG283
E	HIS311
E	GLY312
E	GLY313
E	TYR314
E	GLY315
E	LEU316
E	THR317

site_id	AC6
Number of Residues	31
Details	BINDING SITE FOR RESIDUE FAB F 348

Chain	Residue
F	GLY7
F	ALA8
F	GLY9
F	VAL10
F	ILE11
F	ALA36
F	ASP37
F	ARG38
F	THR43
F	THR44
F	THR45
F	ALA48
F	ALA49
F	GLY50
F	LEU51
F	ARG162
F	LYS163
F	VAL164
F	CYS181
F	THR182
F	TRP185
F	TYR224
F	TYR228
F	ARG283
F	HIS311
F	GLY312
F	GLY313
F	TYR314
F	GLY315
F	LEU316
F	THR317

site_id	AC7
Number of Residues	31
Details	BINDING SITE FOR RESIDUE FAB G 348

Chain	Residue
G	GLY7
G	ALA8
G	GLY9
G	VAL10
G	ILE11
G	ALA36
G	ASP37
G	ARG38
G	THR43
G	THR44
G	THR45
G	ALA48
G	ALA49
G	GLY50
G	LEU51
G	ARG162
G	LYS163
G	VAL164
G	CYS181
G	THR182
G	TRP185
G	TYR224
G	TYR228
G	ARG283
G	HIS311
G	GLY312
G	GLY313
G	TYR314
G	GLY315
G	LEU316
G	THR317

site_id	AC8
Number of Residues	30
Details	BINDING SITE FOR RESIDUE FAB H 348

Chain	Residue
H	GLY7
H	ALA8
H	GLY9
H	VAL10
H	ILE11
H	ALA36
H	ASP37
H	ARG38
H	THR43
H	THR44
H	THR45
H	ALA48
H	ALA49
H	GLY50
H	LEU51
H	ARG162
H	VAL164
H	CYS181
H	THR182
H	TRP185
H	TYR224
H	TYR228
H	ARG283
H	HIS311
H	GLY312
H	GLY313
H	TYR314
H	GLY315
H	LEU316
H	THR317

site_id	FAA
Number of Residues	1
Details	COVALENTLY BOUND COFACTOR.

Chain	Residue
A	FAB348

site_id	FAB
Number of Residues	1
Details	COVALENTLY BOUND COFACTOR.

Chain	Residue
B	FAB348

site_id	FAC
Number of Residues	1
Details	COVALENTLY BOUND COFACTOR.

Chain	Residue
C	FAB348

site_id	FAD
Number of Residues	1
Details	COVALENTLY BOUND COFACTOR.

Chain	Residue
D	FAB348

site_id	FAE
Number of Residues	1
Details	COVALENTLY BOUND COFACTOR.

Chain	Residue
E	FAB348

site_id	FAF
Number of Residues	1
Details	COVALENTLY BOUND COFACTOR.

Chain	Residue
F	FAB348

site_id	FAG
Number of Residues	1
Details	COVALENTLY BOUND COFACTOR.

Chain	Residue
G	FAB348

site_id	FAH
Number of Residues	1
Details	COVALENTLY BOUND COFACTOR.

Chain	Residue
H	FAB348

Functional Information from PROSITE/UniProt

site_id	PS00677
Number of Residues	19
Details	DAO D-amino acid oxidases signature. VIHNYGhGGyGltihwGcA

Chain	Residue	Details
A	VAL305-ALA323

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	64
Details	BINDING: BINDING => ECO:0000269\|PubMed:8755502

Chain	Residue	Details
A	VAL3
B	ASP37
B	THR44
B	ALA49
B	VAL164
B	THR182
B	GLY312
B	THR317
C	VAL3
C	ASP37
C	THR44
A	ASP37
C	ALA49
C	VAL164
C	THR182
C	GLY312
C	THR317
D	VAL3
D	ASP37
D	THR44
D	ALA49
D	VAL164
A	THR44
D	THR182
D	GLY312
D	THR317
E	VAL3
E	ASP37
E	THR44
E	ALA49
E	VAL164
E	THR182
E	GLY312
A	ALA49
E	THR317
F	VAL3
F	ASP37
F	THR44
F	ALA49
F	VAL164
F	THR182
F	GLY312
F	THR317
G	VAL3
A	VAL164
G	ASP37
G	THR44
G	ALA49
G	VAL164
G	THR182
G	GLY312
G	THR317
H	VAL3
H	ASP37
H	THR44
A	THR182
H	ALA49
H	VAL164
H	THR182
H	GLY312
H	THR317
A	GLY312
A	THR317
B	VAL3

site_id	SWS_FT_FI2
Number of Residues	40
Details	BINDING:

Chain	Residue	Details
A	GLN53
B	GLY313
C	GLN53
C	HIS217
C	TYR228
C	ARG283
C	GLY313
D	GLN53
D	HIS217
D	TYR228
D	ARG283
A	HIS217
D	GLY313
E	GLN53
E	HIS217
E	TYR228
E	ARG283
E	GLY313
F	GLN53
F	HIS217
F	TYR228
F	ARG283
A	TYR228
F	GLY313
G	GLN53
G	HIS217
G	TYR228
G	ARG283
G	GLY313
H	GLN53
H	HIS217
H	TYR228
H	ARG283
A	ARG283
H	GLY313
A	GLY313
B	GLN53
B	HIS217
B	TYR228
B	ARG283

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)