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1D9S

TUMOR SUPPRESSOR P15(INK4B) STRUCTURE BY COMPARATIVE MODELING AND NMR DATA

Functional Information from GO Data
ChainGOidnamespacecontents
A0002039molecular_functionp53 binding
A0004861molecular_functioncyclin-dependent protein serine/threonine kinase inhibitor activity
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0007179biological_processtransforming growth factor beta receptor signaling pathway
A0008285biological_processnegative regulation of cell population proliferation
A0016604cellular_componentnuclear body
A0019789molecular_functionSUMO transferase activity
A0019901molecular_functionprotein kinase binding
A0030219biological_processmegakaryocyte differentiation
A0030511biological_processpositive regulation of transforming growth factor beta receptor signaling pathway
A0031670biological_processcellular response to nutrient
A0032991cellular_componentprotein-containing complex
A0035985cellular_componentsenescence-associated heterochromatin focus
A0045786biological_processnegative regulation of cell cycle
A0048536biological_processspleen development
A0050680biological_processnegative regulation of epithelial cell proliferation
A0051059molecular_functionNF-kappaB binding
A0055104molecular_functionligase inhibitor activity
A0060253biological_processnegative regulation of glial cell proliferation
A0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
A0070316biological_processregulation of G0 to G1 transition
A0071460biological_processcellular response to cell-matrix adhesion
A0097371molecular_functionMDM2/MDM4 family protein binding
A0097718molecular_functiondisordered domain specific binding
A1902807biological_processnegative regulation of cell cycle G1/S phase transition
A1990948molecular_functionubiquitin ligase inhibitor activity
A2000045biological_processregulation of G1/S transition of mitotic cell cycle
A2000134biological_processnegative regulation of G1/S transition of mitotic cell cycle
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues29
DetailsRepeat: {"description":"ANK 1"}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues28
DetailsRepeat: {"description":"ANK 2"}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues29
DetailsRepeat: {"description":"ANK 3"}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues26
DetailsRepeat: {"description":"ANK 4"}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"15345747","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

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