1D6I
CHALCONE SYNTHASE (H303Q MUTANT)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0009715 | biological_process | chalcone biosynthetic process |
| A | 0009813 | biological_process | flavonoid biosynthetic process |
| A | 0016210 | molecular_function | naringenin-chalcone synthase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| A | 0030639 | biological_process | polyketide biosynthetic process |
| B | 0009058 | biological_process | biosynthetic process |
| B | 0009715 | biological_process | chalcone biosynthetic process |
| B | 0009813 | biological_process | flavonoid biosynthetic process |
| B | 0016210 | molecular_function | naringenin-chalcone synthase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0030639 | biological_process | polyketide biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 390 |
| Chain | Residue |
| A | VAL2 |
| A | SER3 |
| A | VAL4 |
| A | SER5 |
| B | ARG385 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 391 |
| Chain | Residue |
| B | SER5 |
| A | ARG385 |
| B | VAL2 |
| B | SER3 |
| B | VAL4 |
Functional Information from PROSITE/UniProt
| site_id | PS00441 |
| Number of Residues | 17 |
| Details | CHALCONE_SYNTH Chalcone and stilbene synthases active site. RYmMyQqGCFAGGTvLR |
| Chain | Residue | Details |
| A | ARG156-ARG172 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Acyl-thioester intermediate","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10426957","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10426957","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10653632","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | a catalytic site defined by CSA, PubMed 10653632 |
| Chain | Residue | Details |
| A | PHE215 | |
| A | CSD164 | |
| A | ASN336 | |
| A | GLN303 |
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 355 |
| Chain | Residue | Details |
| A | PHE165 | activator, covalently attached, nucleofuge, nucleophile |
| A | ALA219 | electrostatic destabiliser, polar/non-polar interaction |
| A | PRO307 | electrostatic stabiliser, hydrogen bond donor |
| A | ALA340 | electrostatic stabiliser, hydrogen bond donor |
| site_id | MCSA2 |
| Number of Residues | 4 |
| Details | M-CSA 355 |
| Chain | Residue | Details |
| B | PHE165 | activator, covalently attached, nucleofuge, nucleophile |
| B | ALA219 | electrostatic destabiliser, polar/non-polar interaction |
| B | PRO307 | electrostatic stabiliser, hydrogen bond donor |
| B | ALA340 | electrostatic stabiliser, hydrogen bond donor |
