1D6E
CRYSTAL STRUCTURE OF HLA-DR4 COMPLEX WITH PEPTIDOMIMETIC AND SEB
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0006955 | biological_process | immune response |
A | 0016020 | cellular_component | membrane |
A | 0019882 | biological_process | antigen processing and presentation |
A | 0042613 | cellular_component | MHC class II protein complex |
B | 0006955 | biological_process | immune response |
B | 0016020 | cellular_component | membrane |
B | 0019882 | biological_process | antigen processing and presentation |
B | 0042613 | cellular_component | MHC class II protein complex |
C | 0005515 | molecular_function | protein binding |
C | 0005576 | cellular_component | extracellular region |
C | 0035821 | biological_process | modulation of process of another organism |
C | 0046872 | molecular_function | metal ion binding |
C | 0090729 | molecular_function | toxin activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 21 |
Details | BINDING SITE FOR CHAIN D OF PROTEIN (PEPTIDOMIMETIC INHIBITOR) |
Chain | Residue |
A | GLN9 |
A | ASP66 |
A | ASN69 |
A | GLU179 |
B | HIS13 |
B | TYR30 |
B | LYS71 |
B | ALA74 |
B | THR77 |
B | TYR78 |
B | HIS81 |
A | GLU11 |
B | ASN82 |
B | VAL85 |
A | PHE22 |
A | SER53 |
A | PHE54 |
A | GLY58 |
A | ALA59 |
A | ASN62 |
A | VAL65 |
Functional Information from PROSITE/UniProt
site_id | PS00277 |
Number of Residues | 10 |
Details | STAPH_STREP_TOXIN_1 Staphylococcal enterotoxin/Streptococcal pyrogenic exotoxin signature 1. YGGVTEHngN |
Chain | Residue | Details |
C | TYR115-ASN124 |
site_id | PS00278 |
Number of Residues | 24 |
Details | STAPH_STREP_TOXIN_2 Staphyloccocal enterotoxin/Streptococcal pyrogenic exotoxin signature 2. KkkVtaqeLDyltRhyLvknkkLY |
Chain | Residue | Details |
C | LYS152-TYR175 |
site_id | PS00290 |
Number of Residues | 7 |
Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YDCRVEH |
Chain | Residue | Details |
A | TYR161-HIS167 | |
B | TYR171-HIS177 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819 |
Chain | Residue | Details |
B | ASP57 | |
B | TRP61 | |
B | HIS81 | |
B | ASN82 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:8145819 |
Chain | Residue | Details |
B | ARG93 | |
A | ALA52 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19303388, ECO:0000269|PubMed:24190431 |
Chain | Residue | Details |
B | ASN19 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | SITE: Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819 |
Chain | Residue | Details |
A | SER53 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | SITE: Pathogen-derived peptide antigen => ECO:0000269|PubMed:23260142, ECO:0007744|PDB:4GBX |
Chain | Residue | Details |
A | GLU55 |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | SITE: Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4GBX |
Chain | Residue | Details |
A | ASN62 |
site_id | SWS_FT_FI7 |
Number of Residues | 1 |
Details | SITE: Pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX |
Chain | Residue | Details |
A | ASN69 |
site_id | SWS_FT_FI8 |
Number of Residues | 1 |
Details | SITE: Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX |
Chain | Residue | Details |
A | ARG76 |
site_id | SWS_FT_FI9 |
Number of Residues | 2 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7477400 |
Chain | Residue | Details |
A | ASN78 | |
A | ASN118 |