1D6E
CRYSTAL STRUCTURE OF HLA-DR4 COMPLEX WITH PEPTIDOMIMETIC AND SEB
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006955 | biological_process | immune response |
| A | 0016020 | cellular_component | membrane |
| A | 0019882 | biological_process | antigen processing and presentation |
| A | 0042613 | cellular_component | MHC class II protein complex |
| B | 0006955 | biological_process | immune response |
| B | 0016020 | cellular_component | membrane |
| B | 0019882 | biological_process | antigen processing and presentation |
| B | 0042613 | cellular_component | MHC class II protein complex |
| C | 0005515 | molecular_function | protein binding |
| C | 0005576 | cellular_component | extracellular region |
| C | 0035821 | biological_process | modulation of process of another organism |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0090729 | molecular_function | toxin activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR CHAIN D OF PROTEIN (PEPTIDOMIMETIC INHIBITOR) |
| Chain | Residue |
| A | GLN9 |
| A | ASP66 |
| A | ASN69 |
| A | GLU179 |
| B | HIS13 |
| B | TYR30 |
| B | LYS71 |
| B | ALA74 |
| B | THR77 |
| B | TYR78 |
| B | HIS81 |
| A | GLU11 |
| B | ASN82 |
| B | VAL85 |
| A | PHE22 |
| A | SER53 |
| A | PHE54 |
| A | GLY58 |
| A | ALA59 |
| A | ASN62 |
| A | VAL65 |
Functional Information from PROSITE/UniProt
| site_id | PS00277 |
| Number of Residues | 10 |
| Details | STAPH_STREP_TOXIN_1 Staphylococcal enterotoxin/Streptococcal pyrogenic exotoxin signature 1. YGGVTEHngN |
| Chain | Residue | Details |
| C | TYR115-ASN124 |
| site_id | PS00278 |
| Number of Residues | 24 |
| Details | STAPH_STREP_TOXIN_2 Staphyloccocal enterotoxin/Streptococcal pyrogenic exotoxin signature 2. KkkVtaqeLDyltRhyLvknkkLY |
| Chain | Residue | Details |
| C | LYS152-TYR175 |
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCQVEH |
| Chain | Residue | Details |
| B | TYR171-HIS177 | |
| A | TYR161-HIS167 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 92 |
| Details | Domain: {"description":"Ig-like C1-type"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 93 |
| Details | Region: {"description":"Alpha-2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Site: {"description":"Self- and pathogen-derived peptide antigen","evidences":[{"source":"PubMed","id":"17583734","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21115828","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23260142","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8145819","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4GBX","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Site: {"description":"Self-peptide antigen","evidences":[{"source":"PubMed","id":"31619516","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Site: {"description":"Self- and pathogen-derived peptide antigen","evidences":[{"source":"PubMed","id":"21115828","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8145819","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Site: {"description":"Self- and pathogen-derived peptide antigen","evidences":[{"source":"PubMed","id":"17583734","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21115828","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31619516","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8145819","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Site: {"description":"Pathogen-derived peptide antigen","evidences":[{"source":"PubMed","id":"23260142","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4GBX","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Site: {"description":"Self- and pathogen-derived peptide antigen","evidences":[{"source":"PubMed","id":"17583734","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21115828","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23260142","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31619516","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8145819","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4GBX","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Site: {"description":"Pathogen-derived peptide antigen","evidences":[{"source":"PubMed","id":"17583734","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21115828","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23260142","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8145819","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4FQX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GBX","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Site: {"description":"Self- and pathogen-derived peptide antigen","evidences":[{"source":"PubMed","id":"17583734","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23260142","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31619516","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8145819","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4FQX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GBX","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7477400","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"31619516","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8145819","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"8145819","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19303388","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24190431","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
