1D2C

METHYLTRANSFERASE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005542	molecular_function	folic acid binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005977	biological_process	glycogen metabolic process
A	0006111	biological_process	regulation of gluconeogenesis
A	0006544	biological_process	glycine metabolic process
A	0006555	biological_process	methionine metabolic process
A	0006730	biological_process	one-carbon metabolic process
A	0008168	molecular_function	methyltransferase activity
A	0008757	molecular_function	S-adenosylmethionine-dependent methyltransferase activity
A	0016594	molecular_function	glycine binding
A	0016740	molecular_function	transferase activity
A	0017174	molecular_function	glycine N-methyltransferase activity
A	0032259	biological_process	methylation
A	0034708	cellular_component	methyltransferase complex
A	0042802	molecular_function	identical protein binding
A	0046498	biological_process	S-adenosylhomocysteine metabolic process
A	0046500	biological_process	S-adenosylmethionine metabolic process
A	0051289	biological_process	protein homotetramerization
A	0098603	molecular_function	selenol Se-methyltransferase activity
A	0170033	biological_process	L-amino acid metabolic process
A	0170039	biological_process	proteinogenic amino acid metabolic process
A	1901052	biological_process	sarcosine metabolic process
A	1904047	molecular_function	S-adenosyl-L-methionine binding
B	0005542	molecular_function	folic acid binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005977	biological_process	glycogen metabolic process
B	0006111	biological_process	regulation of gluconeogenesis
B	0006544	biological_process	glycine metabolic process
B	0006555	biological_process	methionine metabolic process
B	0006730	biological_process	one-carbon metabolic process
B	0008168	molecular_function	methyltransferase activity
B	0008757	molecular_function	S-adenosylmethionine-dependent methyltransferase activity
B	0016594	molecular_function	glycine binding
B	0016740	molecular_function	transferase activity
B	0017174	molecular_function	glycine N-methyltransferase activity
B	0032259	biological_process	methylation
B	0034708	cellular_component	methyltransferase complex
B	0042802	molecular_function	identical protein binding
B	0046498	biological_process	S-adenosylhomocysteine metabolic process
B	0046500	biological_process	S-adenosylmethionine metabolic process
B	0051289	biological_process	protein homotetramerization
B	0098603	molecular_function	selenol Se-methyltransferase activity
B	0170033	biological_process	L-amino acid metabolic process
B	0170039	biological_process	proteinogenic amino acid metabolic process
B	1901052	biological_process	sarcosine metabolic process
B	1904047	molecular_function	S-adenosyl-L-methionine binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:22037183, ECO:0000312|PDB:3THR, ECO:0000312|PDB:3THS

Chain	Residue	Details
A	SER3
A	HIS214
A	ARG239
B	SER3
B	HIS214
B	ARG239

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:22037183, ECO:0000312|PDB:3THS

Chain	Residue	Details
A	TYR5
B	TYR5

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:12859184, ECO:0007744|PDB:1NBH

Chain	Residue	Details
A	TYR21
B	TYR21

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:12859184, ECO:0007744|PDB:1NBH, ECO:0007744|PDB:1NBI

Chain	Residue	Details
A	TRP30
A	ARG40
A	ASP85
A	ASN116
B	TRP30
B	ARG40
B	ASP85
B	ASN116

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:8810903, ECO:0007744|PDB:1XVA

Chain	Residue	Details
A	TYR33
A	ARG175
A	TYR220
B	TYR33
B	ARG175
B	TYR220

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:12859184, ECO:0000269|PubMed:8810903, ECO:0000312|PDB:1XVA, ECO:0007744|PDB:1NBH, ECO:0007744|PDB:1NBI

Chain	Residue	Details
A	ALA64
B	ALA64

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:12859184, ECO:0000269|PubMed:8810903, ECO:0007744|PDB:1NBI, ECO:0007744|PDB:1XVA

Chain	Residue	Details
A	LEU136
B	LEU136

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: N-acetylvaline => ECO:0000269|PubMed:2822402

Chain	Residue	Details
A	VAL1
B	VAL1

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9QXF8

Chain	Residue	Details
A	SER9
B	SER9

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q9QXF8

Chain	Residue	Details
A	TYR33
B	TYR33

---

site_id	SWS_FT_FI11
Number of Residues	8
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q9QXF8

Chain	Residue	Details
A	LYS45
A	LYS190
A	LYS195
A	LYS200
B	LYS45
B	LYS190
B	LYS195
B	LYS200

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1xva

Chain	Residue	Details
A	GLU15

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1xva

Chain	Residue	Details
B	GLU15

---

site_id	MCSA1
Number of Residues	5
Details	M-CSA 23

Chain	Residue	Details
A	TYR21	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
A	GLY137	electrostatic stabiliser, hydrogen bond acceptor
A	HIS142	activator
A	ARG175	electrostatic stabiliser
A	TYR194	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor

---

site_id	MCSA2
Number of Residues	5
Details	M-CSA 23

Chain	Residue	Details
B	TYR21	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
B	GLY137	electrostatic stabiliser, hydrogen bond acceptor
B	HIS142	activator
B	ARG175	electrostatic stabiliser
B	TYR194	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor

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