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1D1S

WILD-TYPE HUMAN SIGMA (CLASS IV) ALCOHOL DEHYDROGENASE

Functional Information from GO Data
ChainGOidnamespacecontents
A0001523biological_processretinoid metabolic process
A0004022molecular_functionalcohol dehydrogenase (NAD+) activity
A0004024molecular_functionalcohol dehydrogenase activity, zinc-dependent
A0004031molecular_functionaldehyde oxidase activity
A0004745molecular_functionNAD-retinol dehydrogenase activity
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006069biological_processethanol oxidation
A0006629biological_processlipid metabolic process
A0008270molecular_functionzinc ion binding
A0009617biological_processresponse to bacterium
A0010430biological_processfatty acid omega-oxidation
A0016491molecular_functionoxidoreductase activity
A0018455molecular_functionalcohol dehydrogenase [NAD(P)+] activity
A0019841molecular_functionretinol binding
A0035276molecular_functionethanol binding
A0042572biological_processretinol metabolic process
A0042573biological_processretinoic acid metabolic process
A0044281biological_processsmall molecule metabolic process
A0045471biological_processresponse to ethanol
A0046872molecular_functionmetal ion binding
A0048019molecular_functionreceptor antagonist activity
A0050153molecular_functionomega-hydroxydecanoate dehydrogenase activity
B0001523biological_processretinoid metabolic process
B0004022molecular_functionalcohol dehydrogenase (NAD+) activity
B0004024molecular_functionalcohol dehydrogenase activity, zinc-dependent
B0004031molecular_functionaldehyde oxidase activity
B0004745molecular_functionNAD-retinol dehydrogenase activity
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006069biological_processethanol oxidation
B0006629biological_processlipid metabolic process
B0008270molecular_functionzinc ion binding
B0009617biological_processresponse to bacterium
B0010430biological_processfatty acid omega-oxidation
B0016491molecular_functionoxidoreductase activity
B0018455molecular_functionalcohol dehydrogenase [NAD(P)+] activity
B0019841molecular_functionretinol binding
B0035276molecular_functionethanol binding
B0042572biological_processretinol metabolic process
B0042573biological_processretinoic acid metabolic process
B0044281biological_processsmall molecule metabolic process
B0045471biological_processresponse to ethanol
B0046872molecular_functionmetal ion binding
B0048019molecular_functionreceptor antagonist activity
B0050153molecular_functionomega-hydroxydecanoate dehydrogenase activity
C0001523biological_processretinoid metabolic process
C0004022molecular_functionalcohol dehydrogenase (NAD+) activity
C0004024molecular_functionalcohol dehydrogenase activity, zinc-dependent
C0004031molecular_functionaldehyde oxidase activity
C0004745molecular_functionNAD-retinol dehydrogenase activity
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006069biological_processethanol oxidation
C0006629biological_processlipid metabolic process
C0008270molecular_functionzinc ion binding
C0009617biological_processresponse to bacterium
C0010430biological_processfatty acid omega-oxidation
C0016491molecular_functionoxidoreductase activity
C0018455molecular_functionalcohol dehydrogenase [NAD(P)+] activity
C0019841molecular_functionretinol binding
C0035276molecular_functionethanol binding
C0042572biological_processretinol metabolic process
C0042573biological_processretinoic acid metabolic process
C0044281biological_processsmall molecule metabolic process
C0045471biological_processresponse to ethanol
C0046872molecular_functionmetal ion binding
C0048019molecular_functionreceptor antagonist activity
C0050153molecular_functionomega-hydroxydecanoate dehydrogenase activity
D0001523biological_processretinoid metabolic process
D0004022molecular_functionalcohol dehydrogenase (NAD+) activity
D0004024molecular_functionalcohol dehydrogenase activity, zinc-dependent
D0004031molecular_functionaldehyde oxidase activity
D0004745molecular_functionNAD-retinol dehydrogenase activity
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0006069biological_processethanol oxidation
D0006629biological_processlipid metabolic process
D0008270molecular_functionzinc ion binding
D0009617biological_processresponse to bacterium
D0010430biological_processfatty acid omega-oxidation
D0016491molecular_functionoxidoreductase activity
D0018455molecular_functionalcohol dehydrogenase [NAD(P)+] activity
D0019841molecular_functionretinol binding
D0035276molecular_functionethanol binding
D0042572biological_processretinol metabolic process
D0042573biological_processretinoic acid metabolic process
D0044281biological_processsmall molecule metabolic process
D0045471biological_processresponse to ethanol
D0046872molecular_functionmetal ion binding
D0048019molecular_functionreceptor antagonist activity
D0050153molecular_functionomega-hydroxydecanoate dehydrogenase activity
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 375
ChainResidue
ACYS97
ACYS100
ACYS103
ACYS111

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 376
ChainResidue
ACYS46
AHIS67
ACYS174
AACT501

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN D 375
ChainResidue
DCYS100
DCYS103
DCYS111
DCYS97

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN D 376
ChainResidue
DCYS46
DHIS67
DCYS174
DACT511

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 375
ChainResidue
BCYS97
BCYS100
BCYS103
BCYS111

site_idAC6
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ZN B 376
ChainResidue
BCYS46
BHIS67
BCYS174
BACT506
BNAD2377

site_idAC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN C 375
ChainResidue
CCYS97
CCYS100
CCYS103
CCYS111

site_idAC8
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN C 376
ChainResidue
CCYS46
CHIS67
CCYS174
CACT505

site_idAC9
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 401
ChainResidue
AHIS271
AACT504
AHOH749
ANAD1377

site_idBC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE ZN A 402
ChainResidue
AHIS138
AACT502
AACT513

site_idBC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 403
ChainResidue
BHIS271
BACT507
BHOH735
BNAD2377

site_idBC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 404
ChainResidue
BHIS138
BHOH725
DGLU357
DGLU360

site_idBC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 405
ChainResidue
BASP341
DGLU99
DACT508
DACT509

site_idBC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 406
ChainResidue
BGLU16
BCAC551
BCAC552
BCAC553

site_idBC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN C 407
ChainResidue
CHIS271
CACT510
CHOH771
CNAD3377

site_idBC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 408
ChainResidue
AGLU357
AGLU360
AHOH793
CHIS138

site_idBC8
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN D 409
ChainResidue
DHIS271
DACT512
DHOH780
DNAD4377

site_idBC9
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN D 410
ChainResidue
DHIS138
DACT514
DHOH693
DHOH867

site_idCC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN D 411
ChainResidue
BCAC551
BCAC552
BCAC553
DHIS348

site_idCC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE ACT A 501
ChainResidue
ATHR48
APHE93
AVAL294
AZN376
AHOH916
ANAD1377

site_idCC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ACT A 502
ChainResidue
ALYS60
AVAL122
AHIS138
AZN402
AACT513

site_idCC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE ACT A 504
ChainResidue
AHIS271
AZN401
ANAD1377

site_idCC5
Number of Residues9
DetailsBINDING SITE FOR RESIDUE ACT C 505
ChainResidue
CCYS46
CTHR48
CHIS67
CPHE93
CMET141
CCYS174
CZN376
CHOH956
CNAD3377

site_idCC6
Number of Residues8
DetailsBINDING SITE FOR RESIDUE ACT B 506
ChainResidue
BCYS46
BTHR48
BPHE93
BMET141
BCYS174
BZN376
BHOH933
BNAD2377

site_idCC7
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ACT B 507
ChainResidue
AZN403
BLEU224
BHIS271
BHOH735
BNAD2377

site_idCC8
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ACT D 508
ChainResidue
BZN405
DGLU99
DARG113
DACT509

site_idCC9
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ACT D 509
ChainResidue
BASP341
BZN405
DLYS34
DGLU99
DACT508

site_idDC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE ACT C 510
ChainResidue
CHIS271
CZN407
CNAD3377

site_idDC2
Number of Residues8
DetailsBINDING SITE FOR RESIDUE ACT D 511
ChainResidue
DCYS46
DTHR48
DHIS67
DPHE93
DCYS174
DZN376
DHOH977
DNAD4377

site_idDC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ACT D 512
ChainResidue
DHIS271
DZN409
DHOH780
DHOH1013

site_idDC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE ACT A 513
ChainResidue
AHIS138
AZN402
AACT502

site_idDC5
Number of Residues3
DetailsBINDING SITE FOR RESIDUE ACT D 514
ChainResidue
DHIS138
DZN410
DHOH693

site_idDC6
Number of Residues8
DetailsBINDING SITE FOR RESIDUE CAC B 551
ChainResidue
BGLU16
BPHE61
BZN406
BCAC552
BCAC553
DHIS348
DGLN366
DZN411

site_idDC7
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CAC B 552
ChainResidue
BGLU16
BZN406
BCAC551
BCAC553
DHIS348
DZN411

site_idDC8
Number of Residues7
DetailsBINDING SITE FOR RESIDUE CAC B 553
ChainResidue
BGLU16
BZN406
BCAC551
BCAC552
BHOH903
DHIS348
DZN411

site_idDC9
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CAC A 554
ChainResidue
AMET233
AALA237
AHOH889

site_idEC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CAC B 555
ChainResidue
AGLY259
AASN260
BASN101
BILE112
BHOH613
BHOH622

site_idEC2
Number of Residues28
DetailsBINDING SITE FOR RESIDUE NAD A 1377
ChainResidue
AARG47
ATHR48
AHIS51
ACYS174
ATHR178
AGLY201
AGLY202
AVAL203
AASP223
ALEU224
ALYS228
AVAL268
AILE269
AHIS271
AVAL292
AGLY293
AVAL294
ACYS317
APHE319
AARG369
AZN401
AACT501
AACT504
AHOH623
AHOH888
AHOH901
AHOH911
BPHE309

site_idEC3
Number of Residues28
DetailsBINDING SITE FOR RESIDUE NAD B 2377
ChainResidue
APHE309
AZN403
BARG47
BTHR48
BHIS51
BCYS174
BTHR178
BGLY201
BGLY202
BVAL203
BASP223
BLEU224
BLYS228
BILE269
BHIS271
BVAL292
BGLY293
BVAL294
BCYS317
BVAL318
BPHE319
BARG369
BZN376
BACT506
BACT507
BHOH697
BHOH897
BHOH900

site_idEC4
Number of Residues27
DetailsBINDING SITE FOR RESIDUE NAD C 3377
ChainResidue
CARG47
CTHR48
CHIS51
CCYS174
CTHR178
CGLY201
CGLY202
CVAL203
CASP223
CLEU224
CLYS228
CVAL268
CILE269
CHIS271
CVAL292
CGLY293
CVAL294
CCYS317
CPHE319
CARG369
CZN407
CACT505
CACT510
CHOH770
CHOH771
CHOH845
DPHE309

site_idEC5
Number of Residues24
DetailsBINDING SITE FOR RESIDUE NAD D 4377
ChainResidue
DARG47
DTHR48
DHIS51
DCYS174
DTHR178
DGLY201
DGLY202
DVAL203
DASP223
DLEU224
DLYS228
DVAL268
DILE269
DHIS271
DVAL292
DGLY293
DVAL294
DCYS317
DPHE319
DARG369
DZN409
DACT511
DHOH737
DHOH978

Functional Information from PROSITE/UniProt
site_idPS00059
Number of Residues15
DetailsADH_ZINC Zinc-containing alcohol dehydrogenases signature. GHEaTGIvesiGegV
ChainResidueDetails
AGLY66-VAL80

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues60
DetailsBINDING: BINDING => ECO:0000269|PubMed:10631979, ECO:0007744|PDB:1AGN, ECO:0007744|PDB:1D1S, ECO:0007744|PDB:1D1T
ChainResidueDetails
ASER59
AGLY236
AILE241
ACYS282
APRO305
ALYS330
AARG369
BSER59
BLYS60
BVAL80
BLEU110
ALYS60
BARG113
BILE116
BASP125
BGLY187
BLYS212
BGLY236
BILE241
BCYS282
BPRO305
BLYS330
AVAL80
BARG369
CSER59
CLYS60
CVAL80
CLEU110
CARG113
CILE116
CASP125
CGLY187
CLYS212
ALEU110
CGLY236
CILE241
CCYS282
CPRO305
CLYS330
CARG369
DSER59
DLYS60
DVAL80
DLEU110
AARG113
DARG113
DILE116
DASP125
DGLY187
DLYS212
DGLY236
DILE241
DCYS282
DPRO305
DLYS330
AILE116
DARG369
AASP125
AGLY187
ALYS212

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PDB entries from 2024-03-27

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