1D1Q

CRYSTAL STRUCTURE OF A YEAST LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE (LTP1) COMPLEXED WITH THE SUBSTRATE PNPP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003993	molecular_function	acid phosphatase activity
A	0004721	molecular_function	phosphoprotein phosphatase activity
A	0004725	molecular_function	protein tyrosine phosphatase activity
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0006470	biological_process	protein dephosphorylation
B	0003993	molecular_function	acid phosphatase activity
B	0004721	molecular_function	phosphoprotein phosphatase activity
B	0004725	molecular_function	protein tyrosine phosphatase activity
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0006470	biological_process	protein dephosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PO4 B 402

Chain	Residue
B	ALA13
B	HOH426
B	LEU14
B	GLY15
B	ASN16
B	PHE17
B	CYS18
B	ARG19
B	SER20
B	HOH415

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site_id	AC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE 4NP A 401

Chain	Residue
A	GLU3
A	ALA13
A	LEU14
A	GLY15
A	ASN16
A	PHE17
A	CYS18
A	ARG19
A	ASP132
A	TRP134
A	HOH457
B	TYR51
B	HOH432

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site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL B 403

Chain	Residue
A	ILE64
A	GLN67
A	GLN139
A	HOH436
A	HOH469
A	HOH490
A	HOH491
B	TRP134
B	TYR135

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Nucleophile => ECO:0000269|PubMed:10684639, ECO:0007744|PDB:1D1Q

Chain	Residue	Details
A	ALA13
B	ALA13

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site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: Transition state stabilizer => ECO:0000269|PubMed:10684639, ECO:0007744|PDB:1D1Q

Chain	Residue	Details
A	ARG19
B	ARG19

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site_id	SWS_FT_FI3
Number of Residues	2
Details	ACT_SITE: Proton donor => ECO:0000269|PubMed:10684639, ECO:0007744|PDB:1D1Q

Chain	Residue	Details
A	ASP132
B	ASP132

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site_id	SWS_FT_FI4
Number of Residues	2
Details	SITE: Important for catalytic activity => ECO:0000269|PubMed:10684639, ECO:0007744|PDB:1D1Q

Chain	Residue	Details
A	SER20
B	SER20

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site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956

Chain	Residue	Details
A	SER56
B	SER56

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	a catalytic site defined by CSA, PubMed 10684639, 12882518, 10409830

Chain	Residue	Details
A	ALA13
A	ARG19
A	SER20
A	ASP132

---

site_id	CSA2
Number of Residues	4
Details	a catalytic site defined by CSA, PubMed 10684639, 12882518, 10409830

Chain	Residue	Details
B	ALA13
B	ARG19
B	SER20
B	ASP132

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