1D1G
DIHYDROFOLATE REDUCTASE FROM THERMOTOGA MARITIMA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004146 | molecular_function | dihydrofolate reductase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046452 | biological_process | dihydrofolate metabolic process |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0046655 | biological_process | folic acid metabolic process |
| A | 0050661 | molecular_function | NADP binding |
| B | 0004146 | molecular_function | dihydrofolate reductase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006730 | biological_process | one-carbon metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0046452 | biological_process | dihydrofolate metabolic process |
| B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| B | 0046655 | biological_process | folic acid metabolic process |
| B | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE NDP A 170 |
| Chain | Residue |
| A | LEU7 |
| A | LEU63 |
| A | THR64 |
| A | ARG65 |
| A | ARG66 |
| A | GLY80 |
| A | ILE100 |
| A | GLY101 |
| A | GLY102 |
| A | LYS103 |
| A | THR104 |
| A | ALA8 |
| A | GLU108 |
| A | ILE131 |
| A | MTX171 |
| A | HOH534 |
| A | HOH556 |
| A | HOH580 |
| A | ILE15 |
| A | ALA16 |
| A | GLY44 |
| A | ARG45 |
| A | ILE46 |
| A | THR47 |
| A | GLU50 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE MTX A 171 |
| Chain | Residue |
| A | VAL6 |
| A | LEU7 |
| A | ALA8 |
| A | ASP27 |
| A | ARG28 |
| A | LYS29 |
| A | PHE31 |
| A | ARG32 |
| A | GLU50 |
| A | ILE51 |
| A | ARG53 |
| A | LEU55 |
| A | ARG58 |
| A | ILE100 |
| A | THR121 |
| A | NDP170 |
| A | HOH502 |
| site_id | AC3 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE NDP B 170 |
| Chain | Residue |
| B | LEU7 |
| B | ALA8 |
| B | ILE15 |
| B | GLY44 |
| B | ARG45 |
| B | ILE46 |
| B | THR47 |
| B | GLU50 |
| B | LEU63 |
| B | THR64 |
| B | ARG65 |
| B | ARG66 |
| B | GLY80 |
| B | ILE100 |
| B | GLY101 |
| B | GLY102 |
| B | LYS103 |
| B | THR104 |
| B | GLU108 |
| B | ILE131 |
| B | MTX171 |
| B | HOH641 |
| site_id | AC4 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE MTX B 171 |
| Chain | Residue |
| B | VAL6 |
| B | LEU7 |
| B | ALA8 |
| B | ASP27 |
| B | ARG28 |
| B | PHE31 |
| B | ARG32 |
| B | GLU50 |
| B | ILE51 |
| B | ARG53 |
| B | LEU55 |
| B | ARG58 |
| B | ILE100 |
| B | THR121 |
| B | NDP170 |
| B | HOH503 |
| B | HOH571 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:10731419 |
| Chain | Residue | Details |
| A | VAL6 | |
| B | ILE100 | |
| A | ASP27 | |
| A | ARG53 | |
| A | ARG58 | |
| A | ILE100 | |
| B | VAL6 | |
| B | ASP27 | |
| B | ARG53 | |
| B | ARG58 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10731419 |
| Chain | Residue | Details |
| A | ALA8 | |
| B | THR64 | |
| B | GLY80 | |
| B | GLY102 | |
| A | ILE15 | |
| A | ARG45 | |
| A | THR64 | |
| A | GLY80 | |
| A | GLY102 | |
| B | ALA8 | |
| B | ILE15 | |
| B | ARG45 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dhf |
| Chain | Residue | Details |
| A | VAL19 | |
| A | ASP27 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dhf |
| Chain | Residue | Details |
| B | VAL19 | |
| B | ASP27 |
