1D0G
CRYSTAL STRUCTURE OF DEATH RECEPTOR 5 (DR5) BOUND TO APO2L/TRAIL
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005164 | molecular_function | tumor necrosis factor receptor binding |
| A | 0006955 | biological_process | immune response |
| A | 0016020 | cellular_component | membrane |
| B | 0005164 | molecular_function | tumor necrosis factor receptor binding |
| B | 0006955 | biological_process | immune response |
| B | 0016020 | cellular_component | membrane |
| D | 0005164 | molecular_function | tumor necrosis factor receptor binding |
| D | 0006955 | biological_process | immune response |
| D | 0016020 | cellular_component | membrane |
| R | 0045569 | molecular_function | TRAIL binding |
| S | 0045569 | molecular_function | TRAIL binding |
| T | 0045569 | molecular_function | TRAIL binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 300 |
| Chain | Residue |
| A | CYS230 |
| B | CYS230 |
| B | CL400 |
| D | CYS230 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 400 |
| Chain | Residue |
| A | CYS230 |
| A | ZN300 |
| B | CYS230 |
| D | CYS230 |
Functional Information from PROSITE/UniProt
| site_id | PS00251 |
| Number of Residues | 17 |
| Details | THD_1 Tumor necrosis factor (TNF) homology domain (THD) signature. LvIHeKGFYYIysQTyF |
| Chain | Residue | Details |
| A | LEU174-PHE190 |
| site_id | PS00652 |
| Number of Residues | 41 |
| Details | TNFR_NGFR_1 TNFR/NGFR family cysteine-rich region signature. Ckygqd.Ysthwndllf.ClrCtr.Cdsgevelsp..Ctttr..NTVC |
| Chain | Residue | Details |
| R | CYS44-CYS84 | |
| R | CYS84-CYS125 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 120 |
| Details | Repeat: {"description":"TNFR-Cys 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 120 |
| Details | Repeat: {"description":"TNFR-Cys 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10549288","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26457518","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5CIR","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
