1CYN
CYCLOPHILIN B COMPLEXED WITH [D-(CHOLINYLESTER)SER8]-CYCLOSPORIN
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000413 | biological_process | protein peptidyl-prolyl isomerization |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003755 | molecular_function | peptidyl-prolyl cis-trans isomerase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005518 | molecular_function | collagen binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005788 | cellular_component | endoplasmic reticulum lumen |
| A | 0005790 | cellular_component | smooth endoplasmic reticulum |
| A | 0005829 | cellular_component | cytosol |
| A | 0005925 | cellular_component | focal adhesion |
| A | 0006457 | biological_process | protein folding |
| A | 0016018 | molecular_function | cyclosporin A binding |
| A | 0016020 | cellular_component | membrane |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0030593 | biological_process | neutrophil chemotaxis |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0034663 | cellular_component | endoplasmic reticulum chaperone complex |
| A | 0040018 | biological_process | positive regulation of multicellular organism growth |
| A | 0042470 | cellular_component | melanosome |
| A | 0044794 | biological_process | host-mediated activation of viral process |
| A | 0044829 | biological_process | host-mediated activation of viral genome replication |
| A | 0048471 | cellular_component | perinuclear region of cytoplasm |
| A | 0050821 | biological_process | protein stabilization |
| A | 0051082 | molecular_function | unfolded protein binding |
| A | 0060348 | biological_process | bone development |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070063 | molecular_function | RNA polymerase binding |
| A | 1901873 | biological_process | regulation of post-translational protein modification |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR CHAIN C OF CYCLOSPORIN A |
| Chain | Residue |
| A | ARG63 |
| A | TRP129 |
| A | HIS134 |
| C | HOH2001 |
| C | HOH2002 |
| C | HOH2004 |
| C | HOH2006 |
| C | HOH2007 |
| A | PHE68 |
| A | GLN71 |
| A | GLY80 |
| A | ALA109 |
| A | ASN110 |
| A | ALA111 |
| A | GLN119 |
| A | PHE121 |
Functional Information from PROSITE/UniProt
| site_id | PS00170 |
| Number of Residues | 18 |
| Details | CSA_PPIASE_1 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. YknSkFHRVIkdFMiQGG |
| Chain | Residue | Details |
| A | TYR56-GLY73 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 157 |
| Details | Domain: {"description":"PPIase cyclophilin-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00156","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Motif: {"description":"Prevents secretion from ER"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q99KR7","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q99KR7","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"UniProtKB","id":"Q99KR7","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P24369","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
