1CY0
COMPLEX OF E.COLI DNA TOPOISOMERASE I WITH 3'-5'-ADENOSINE DIPHOSPHATE
Functional Information from GO Data
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE A3P A 605 |
Chain | Residue |
A | SER340 |
A | HOH606 |
A | HOH728 |
A | ASP341 |
A | LEU348 |
A | GLU520 |
A | LYS521 |
A | MET522 |
A | ILE525 |
A | HIS566 |
A | SER569 |
Functional Information from PROSITE/UniProt
site_id | PS00396 |
Number of Residues | 15 |
Details | TOPO_IA_1 Topoisomerase (Topo) IA-type active site signature. QrLYEagy.........ITYmRTD |
Chain | Residue | Details |
A | GLN309-ASP323 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: O-(5'-phospho-DNA)-tyrosine intermediate => ECO:0000255|PROSITE-ProRule:PRU01383, ECO:0000269|PubMed:21482796, ECO:0000269|PubMed:8114910, ECO:0000269|PubMed:9497321 |
Chain | Residue | Details |
A | TYR319 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00952 |
Chain | Residue | Details |
A | GLU9 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000305 |
Chain | Residue | Details |
A | ASP111 |
site_id | SWS_FT_FI4 |
Number of Residues | 8 |
Details | SITE: Interaction with DNA |
Chain | Residue | Details |
A | HIS33 | |
A | ARG168 | |
A | ARG169 | |
A | ASP172 | |
A | TYR177 | |
A | TRP184 | |
A | ARG321 | |
A | ARG507 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 7 |
Details | M-CSA 366 |
Chain | Residue | Details |
A | GLU9 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, increase acidity, metal ligand, proton acceptor, proton donor, proton relay |
A | ASP111 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, increase acidity, metal ligand, proton acceptor, proton donor, proton relay |
A | ASP113 | metal ligand |
A | GLU115 | metal ligand |
A | TYR319 | activator, covalently attached, hydrogen bond acceptor, nucleofuge, nucleophile, proton acceptor, proton donor |
A | ARG321 | electrostatic stabiliser |
A | HIS365 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, increase acidity, proton acceptor, proton donor |