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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

1CVI

CRYSTAL STRUCTURE OF HUMAN PROSTATIC ACID PHOSPHATASE

Functional Information from GO Data
ChainGOidnamespacecontents
A0003993molecular_functionacid phosphatase activity
A0004725molecular_functionprotein tyrosine phosphatase activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005765cellular_componentlysosomal membrane
A0005771cellular_componentmultivesicular body
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006144biological_processpurine nucleobase metabolic process
A0006629biological_processlipid metabolic process
A0006772biological_processthiamine metabolic process
A0008253molecular_function5'-nucleotidase activity
A0009117biological_processnucleotide metabolic process
A0012506cellular_componentvesicle membrane
A0016020cellular_componentmembrane
A0016787molecular_functionhydrolase activity
A0016791molecular_functionphosphatase activity
A0030141cellular_componentsecretory granule
A0030175cellular_componentfilopodium
A0031985cellular_componentGolgi cisterna
A0033265molecular_functioncholine binding
A0035577cellular_componentazurophil granule membrane
A0042131molecular_functionthiamine phosphate phosphatase activity
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0045177cellular_componentapical part of cell
A0046085biological_processadenosine metabolic process
A0051930biological_processregulation of sensory perception of pain
A0052642molecular_functionlysophosphatidic acid phosphatase activity
A0060090molecular_functionmolecular adaptor activity
A0060168biological_processpositive regulation of adenosine receptor signaling pathway
A0070062cellular_componentextracellular exosome
B0003993molecular_functionacid phosphatase activity
B0004725molecular_functionprotein tyrosine phosphatase activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005765cellular_componentlysosomal membrane
B0005771cellular_componentmultivesicular body
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006144biological_processpurine nucleobase metabolic process
B0006629biological_processlipid metabolic process
B0006772biological_processthiamine metabolic process
B0008253molecular_function5'-nucleotidase activity
B0009117biological_processnucleotide metabolic process
B0012506cellular_componentvesicle membrane
B0016020cellular_componentmembrane
B0016787molecular_functionhydrolase activity
B0016791molecular_functionphosphatase activity
B0030141cellular_componentsecretory granule
B0030175cellular_componentfilopodium
B0031985cellular_componentGolgi cisterna
B0033265molecular_functioncholine binding
B0035577cellular_componentazurophil granule membrane
B0042131molecular_functionthiamine phosphate phosphatase activity
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0045177cellular_componentapical part of cell
B0046085biological_processadenosine metabolic process
B0051930biological_processregulation of sensory perception of pain
B0052642molecular_functionlysophosphatidic acid phosphatase activity
B0060090molecular_functionmolecular adaptor activity
B0060168biological_processpositive regulation of adenosine receptor signaling pathway
B0070062cellular_componentextracellular exosome
C0003993molecular_functionacid phosphatase activity
C0004725molecular_functionprotein tyrosine phosphatase activity
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005765cellular_componentlysosomal membrane
C0005771cellular_componentmultivesicular body
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006144biological_processpurine nucleobase metabolic process
C0006629biological_processlipid metabolic process
C0006772biological_processthiamine metabolic process
C0008253molecular_function5'-nucleotidase activity
C0009117biological_processnucleotide metabolic process
C0012506cellular_componentvesicle membrane
C0016020cellular_componentmembrane
C0016787molecular_functionhydrolase activity
C0016791molecular_functionphosphatase activity
C0030141cellular_componentsecretory granule
C0030175cellular_componentfilopodium
C0031985cellular_componentGolgi cisterna
C0033265molecular_functioncholine binding
C0035577cellular_componentazurophil granule membrane
C0042131molecular_functionthiamine phosphate phosphatase activity
C0042802molecular_functionidentical protein binding
C0042803molecular_functionprotein homodimerization activity
C0045177cellular_componentapical part of cell
C0046085biological_processadenosine metabolic process
C0051930biological_processregulation of sensory perception of pain
C0052642molecular_functionlysophosphatidic acid phosphatase activity
C0060090molecular_functionmolecular adaptor activity
C0060168biological_processpositive regulation of adenosine receptor signaling pathway
C0070062cellular_componentextracellular exosome
D0003993molecular_functionacid phosphatase activity
D0004725molecular_functionprotein tyrosine phosphatase activity
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005634cellular_componentnucleus
D0005765cellular_componentlysosomal membrane
D0005771cellular_componentmultivesicular body
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0006144biological_processpurine nucleobase metabolic process
D0006629biological_processlipid metabolic process
D0006772biological_processthiamine metabolic process
D0008253molecular_function5'-nucleotidase activity
D0009117biological_processnucleotide metabolic process
D0012506cellular_componentvesicle membrane
D0016020cellular_componentmembrane
D0016787molecular_functionhydrolase activity
D0016791molecular_functionphosphatase activity
D0030141cellular_componentsecretory granule
D0030175cellular_componentfilopodium
D0031985cellular_componentGolgi cisterna
D0033265molecular_functioncholine binding
D0035577cellular_componentazurophil granule membrane
D0042131molecular_functionthiamine phosphate phosphatase activity
D0042802molecular_functionidentical protein binding
D0042803molecular_functionprotein homodimerization activity
D0045177cellular_componentapical part of cell
D0046085biological_processadenosine metabolic process
D0051930biological_processregulation of sensory perception of pain
D0052642molecular_functionlysophosphatidic acid phosphatase activity
D0060090molecular_functionmolecular adaptor activity
D0060168biological_processpositive regulation of adenosine receptor signaling pathway
D0070062cellular_componentextracellular exosome
Functional Information from PROSITE/UniProt
site_idPS00616
Number of Residues15
DetailsHIS_ACID_PHOSPHAT_1 Histidine acid phosphatases phosphohistidine signature. LkfVtlVfRHGdRsP
ChainResidueDetails
ALEU1003-PRO1017
site_idPS00778
Number of Residues17
DetailsHIS_ACID_PHOSPHAT_2 Histidine acid phosphatases active site signature. LiMYsAHDTTVsgLqmA
ChainResidueDetails
ALEU1251-ALA1267
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues152
DetailsPeptide: {"description":"PAPf39","featureId":"PRO_0000411250","evidences":[{"source":"PubMed","id":"18083097","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues4
DetailsActive site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"1989985","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues4
DetailsActive site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"1989985","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues16
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"9804805","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues4
DetailsSite: {"description":"Important for substrate specificity"}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues8
DetailsSite: {"description":"Required for homodimerization","evidences":[{"source":"UniProtKB","id":"P20646","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues4
DetailsSite: {"description":"Required for structural stability","evidences":[{"source":"PubMed","id":"9584846","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"10639192","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"10639192","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12525165","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12525165","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
Catalytic Information from CSA
site_idCSA1
Number of Residues6
DetailsAnnotated By Reference To The Literature 1rpt
ChainResidueDetails
AARG1079
AARG1011
AHIS1257
AHIS1012
AASP1258
AARG1015
site_idCSA2
Number of Residues6
DetailsAnnotated By Reference To The Literature 1rpt
ChainResidueDetails
BARG2079
BASP2258
BARG2011
BARG2015
BHIS2012
BHIS2257
site_idCSA3
Number of Residues6
DetailsAnnotated By Reference To The Literature 1rpt
ChainResidueDetails
CARG3011
CASP3258
CARG3079
CARG3015
CHIS3012
CHIS3257
site_idCSA4
Number of Residues6
DetailsAnnotated By Reference To The Literature 1rpt
ChainResidueDetails
DASP4258
DARG4011
DHIS4012
DHIS4257
DARG4015
DARG4079

244693

PDB entries from 2025-11-12

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