1CS0
Crystal structure of carbamoyl phosphate synthetase complexed at CYS269 in the small subunit with the tetrahedral mimic l-glutamate gamma-semialdehyde
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004087 | molecular_function | carbamoyl-phosphate synthase (ammonia) activity |
| A | 0004088 | molecular_function | carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005951 | cellular_component | carbamoyl-phosphate synthase complex |
| A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| A | 0006526 | biological_process | arginine biosynthetic process |
| A | 0006541 | biological_process | glutamine metabolic process |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0016597 | molecular_function | amino acid binding |
| A | 0016874 | molecular_function | ligase activity |
| A | 0019856 | biological_process | pyrimidine nucleobase biosynthetic process |
| A | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004088 | molecular_function | carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity |
| B | 0004359 | molecular_function | glutaminase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005951 | cellular_component | carbamoyl-phosphate synthase complex |
| B | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| B | 0006526 | biological_process | arginine biosynthetic process |
| B | 0006541 | biological_process | glutamine metabolic process |
| B | 0016874 | molecular_function | ligase activity |
| B | 0019856 | biological_process | pyrimidine nucleobase biosynthetic process |
| B | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| B | 0046982 | molecular_function | protein heterodimerization activity |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0004087 | molecular_function | carbamoyl-phosphate synthase (ammonia) activity |
| C | 0004088 | molecular_function | carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0005951 | cellular_component | carbamoyl-phosphate synthase complex |
| C | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| C | 0006526 | biological_process | arginine biosynthetic process |
| C | 0006541 | biological_process | glutamine metabolic process |
| C | 0008652 | biological_process | amino acid biosynthetic process |
| C | 0016597 | molecular_function | amino acid binding |
| C | 0016874 | molecular_function | ligase activity |
| C | 0019856 | biological_process | pyrimidine nucleobase biosynthetic process |
| C | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0004088 | molecular_function | carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity |
| D | 0004359 | molecular_function | glutaminase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0005951 | cellular_component | carbamoyl-phosphate synthase complex |
| D | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| D | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| D | 0006526 | biological_process | arginine biosynthetic process |
| D | 0006541 | biological_process | glutamine metabolic process |
| D | 0016874 | molecular_function | ligase activity |
| D | 0019856 | biological_process | pyrimidine nucleobase biosynthetic process |
| D | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| D | 0046982 | molecular_function | protein heterodimerization activity |
| E | 0000166 | molecular_function | nucleotide binding |
| E | 0004087 | molecular_function | carbamoyl-phosphate synthase (ammonia) activity |
| E | 0004088 | molecular_function | carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity |
| E | 0005515 | molecular_function | protein binding |
| E | 0005524 | molecular_function | ATP binding |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005829 | cellular_component | cytosol |
| E | 0005951 | cellular_component | carbamoyl-phosphate synthase complex |
| E | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| E | 0006526 | biological_process | arginine biosynthetic process |
| E | 0006541 | biological_process | glutamine metabolic process |
| E | 0008652 | biological_process | amino acid biosynthetic process |
| E | 0016597 | molecular_function | amino acid binding |
| E | 0016874 | molecular_function | ligase activity |
| E | 0019856 | biological_process | pyrimidine nucleobase biosynthetic process |
| E | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| E | 0046872 | molecular_function | metal ion binding |
| F | 0004088 | molecular_function | carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity |
| F | 0004359 | molecular_function | glutaminase activity |
| F | 0005515 | molecular_function | protein binding |
| F | 0005524 | molecular_function | ATP binding |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005829 | cellular_component | cytosol |
| F | 0005951 | cellular_component | carbamoyl-phosphate synthase complex |
| F | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| F | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| F | 0006526 | biological_process | arginine biosynthetic process |
| F | 0006541 | biological_process | glutamine metabolic process |
| F | 0016874 | molecular_function | ligase activity |
| F | 0019856 | biological_process | pyrimidine nucleobase biosynthetic process |
| F | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| F | 0046982 | molecular_function | protein heterodimerization activity |
| G | 0000166 | molecular_function | nucleotide binding |
| G | 0004087 | molecular_function | carbamoyl-phosphate synthase (ammonia) activity |
| G | 0004088 | molecular_function | carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity |
| G | 0005515 | molecular_function | protein binding |
| G | 0005524 | molecular_function | ATP binding |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0005829 | cellular_component | cytosol |
| G | 0005951 | cellular_component | carbamoyl-phosphate synthase complex |
| G | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| G | 0006526 | biological_process | arginine biosynthetic process |
| G | 0006541 | biological_process | glutamine metabolic process |
| G | 0008652 | biological_process | amino acid biosynthetic process |
| G | 0016597 | molecular_function | amino acid binding |
| G | 0016874 | molecular_function | ligase activity |
| G | 0019856 | biological_process | pyrimidine nucleobase biosynthetic process |
| G | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| G | 0046872 | molecular_function | metal ion binding |
| H | 0004088 | molecular_function | carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity |
| H | 0004359 | molecular_function | glutaminase activity |
| H | 0005515 | molecular_function | protein binding |
| H | 0005524 | molecular_function | ATP binding |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0005829 | cellular_component | cytosol |
| H | 0005951 | cellular_component | carbamoyl-phosphate synthase complex |
| H | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| H | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| H | 0006526 | biological_process | arginine biosynthetic process |
| H | 0006541 | biological_process | glutamine metabolic process |
| H | 0016874 | molecular_function | ligase activity |
| H | 0019856 | biological_process | pyrimidine nucleobase biosynthetic process |
| H | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| H | 0046982 | molecular_function | protein heterodimerization activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN A 5001 |
| Chain | Residue |
| A | GLU299 |
| A | ASN301 |
| A | ADP5000 |
| A | MN5002 |
| A | PO45005 |
| A | HOH5158 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MN A 5002 |
| Chain | Residue |
| A | MN5001 |
| A | PO45005 |
| A | K5021 |
| A | HOH5157 |
| A | GLN285 |
| A | GLU299 |
| A | ADP5000 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K A 5003 |
| Chain | Residue |
| A | GLU215 |
| A | ASN236 |
| A | ASP238 |
| A | ALA239 |
| A | ILE242 |
| A | SER247 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE K A 5004 |
| Chain | Residue |
| A | ALA126 |
| A | GLU127 |
| A | GLU299 |
| A | MET300 |
| A | ASN301 |
| A | HOH5158 |
| A | HOH5252 |
| A | HOH5912 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN A 5007 |
| Chain | Residue |
| A | GLN829 |
| A | GLU841 |
| A | ADP5006 |
| A | HOH5165 |
| A | HOH5948 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE K A 5008 |
| Chain | Residue |
| A | GLU841 |
| A | ASN843 |
| A | ADP5006 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K A 5009 |
| Chain | Residue |
| A | GLU761 |
| A | HIS781 |
| A | GLU783 |
| A | GLN784 |
| A | VAL787 |
| A | SER792 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL A 5011 |
| Chain | Residue |
| A | GLN93 |
| A | THR173 |
| A | MET174 |
| A | HOH5133 |
| A | HOH5134 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 5012 |
| Chain | Residue |
| A | ASN289 |
| A | ASN292 |
| A | ARG294 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 5013 |
| Chain | Residue |
| A | ASN371 |
| A | PHE900 |
| A | PRO901 |
| A | GLY902 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 5014 |
| Chain | Residue |
| A | LYS940 |
| A | LYS941 |
| A | HIS942 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 5015 |
| Chain | Residue |
| A | ARG950 |
| A | GLY952 |
| A | SER1018 |
| site_id | BC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL B 5016 |
| Chain | Residue |
| B | LYS285 |
| site_id | BC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 5017 |
| Chain | Residue |
| B | ASP114 |
| B | HOH5058 |
| site_id | BC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 5018 |
| Chain | Residue |
| A | ARG294 |
| A | HOH5711 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K A 5019 |
| Chain | Residue |
| A | ASP84 |
| A | GLY112 |
| A | THR114 |
| A | HOH5172 |
| A | HOH5173 |
| A | HOH5730 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE K B 5020 |
| Chain | Residue |
| B | HIS16 |
| B | ASP112 |
| B | HOH5057 |
| B | HOH5058 |
| site_id | BC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE K A 5021 |
| Chain | Residue |
| A | GLU217 |
| A | THR244 |
| A | ASN283 |
| A | GLN285 |
| A | MN5002 |
| A | PO45005 |
| A | HOH5161 |
| site_id | CC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE K A 5022 |
| Chain | Residue |
| A | THR143 |
| A | ALA144 |
| A | HOH5261 |
| site_id | CC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL E 5058 |
| Chain | Residue |
| E | GLN93 |
| E | THR173 |
| E | MET174 |
| E | HOH5116 |
| site_id | CC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K G 5090 |
| Chain | Residue |
| G | ASP84 |
| G | GLY112 |
| G | THR114 |
| G | HOH5177 |
| G | HOH5715 |
| site_id | CC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN C 5024 |
| Chain | Residue |
| C | GLU299 |
| C | ASN301 |
| C | HOH1157 |
| C | ADP5023 |
| C | MN5025 |
| C | PO45028 |
| site_id | CC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL E 5059 |
| Chain | Residue |
| E | ASN289 |
| E | ASN292 |
| E | ARG294 |
| site_id | CC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE K H 5091 |
| Chain | Residue |
| G | HOH5530 |
| H | HIS16 |
| H | ASP112 |
| site_id | CC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN C 5025 |
| Chain | Residue |
| C | GLN285 |
| C | GLU299 |
| C | HOH1156 |
| C | ADP5023 |
| C | MN5024 |
| C | PO45028 |
| site_id | CC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL E 5060 |
| Chain | Residue |
| E | ASN371 |
| E | PHE900 |
| E | PRO901 |
| E | GLY902 |
| site_id | CC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE K G 5092 |
| Chain | Residue |
| G | GLU217 |
| G | THR244 |
| G | ASN283 |
| G | GLN285 |
| G | MN5073 |
| G | PO45076 |
| G | HOH5165 |
| site_id | DC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K C 5026 |
| Chain | Residue |
| C | GLU215 |
| C | ASN236 |
| C | ASP238 |
| C | ALA239 |
| C | ILE242 |
| C | SER247 |
| site_id | DC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL E 5061 |
| Chain | Residue |
| E | LYS941 |
| site_id | DC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE K G 5093 |
| Chain | Residue |
| G | THR143 |
| G | ALA144 |
| G | HOH5265 |
| G | HOH5266 |
| site_id | DC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE K C 5027 |
| Chain | Residue |
| C | ALA126 |
| C | GLU127 |
| C | GLU299 |
| C | MET300 |
| C | ASN301 |
| C | HOH1250 |
| C | HOH1849 |
| site_id | DC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL E 5062 |
| Chain | Residue |
| E | ARG950 |
| E | GLU951 |
| E | GLY952 |
| site_id | DC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN C 5030 |
| Chain | Residue |
| C | GLN829 |
| C | GLU841 |
| C | HOH1164 |
| C | HOH1851 |
| C | ADP5029 |
| site_id | DC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL F 5063 |
| Chain | Residue |
| F | LYS285 |
| site_id | DC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE K C 5031 |
| Chain | Residue |
| C | GLU841 |
| C | ASN843 |
| C | HOH1651 |
| C | ADP5029 |
| site_id | DC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL F 5064 |
| Chain | Residue |
| F | PHE15 |
| F | ASP114 |
| F | HOH2657 |
| site_id | EC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K C 5032 |
| Chain | Residue |
| C | GLU761 |
| C | HIS781 |
| C | GLU783 |
| C | GLN784 |
| C | VAL787 |
| C | SER792 |
| site_id | EC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE K E 5065 |
| Chain | Residue |
| E | ASP84 |
| E | GLY112 |
| E | THR114 |
| E | HOH5704 |
| site_id | EC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL C 5035 |
| Chain | Residue |
| C | GLN93 |
| C | THR173 |
| C | MET174 |
| C | HOH1132 |
| site_id | EC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE K F 5066 |
| Chain | Residue |
| E | HOH5511 |
| F | HIS16 |
| F | ASP112 |
| F | HOH2618 |
| site_id | EC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL C 5036 |
| Chain | Residue |
| C | ASN289 |
| C | ASN292 |
| C | ARG294 |
| site_id | EC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K E 5067 |
| Chain | Residue |
| E | GLU217 |
| E | THR244 |
| E | ASN283 |
| E | GLN285 |
| E | PO45051 |
| E | HOH5143 |
| site_id | EC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL C 5037 |
| Chain | Residue |
| C | ALA370 |
| C | ASN371 |
| C | PHE900 |
| C | PRO901 |
| C | GLY902 |
| site_id | EC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE K E 5068 |
| Chain | Residue |
| E | THR279 |
| site_id | EC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL C 5038 |
| Chain | Residue |
| C | LYS940 |
| C | LYS941 |
| site_id | FC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE K E 5069 |
| Chain | Residue |
| E | THR143 |
| E | ALA144 |
| E | HOH5243 |
| site_id | FC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL C 5039 |
| Chain | Residue |
| C | ARG950 |
| C | SER1018 |
| site_id | FC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN G 5072 |
| Chain | Residue |
| G | GLU299 |
| G | ASN301 |
| G | ADP5071 |
| G | MN5073 |
| G | PO45076 |
| G | HOH5162 |
| site_id | FC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL D 5040 |
| Chain | Residue |
| D | LYS285 |
| site_id | FC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MN G 5073 |
| Chain | Residue |
| G | GLN285 |
| G | GLU299 |
| G | ADP5071 |
| G | MN5072 |
| G | PO45076 |
| G | K5092 |
| G | HOH5161 |
| site_id | FC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL D 5041 |
| Chain | Residue |
| C | GLU549 |
| C | HOH1562 |
| D | PHE15 |
| D | ASP114 |
| D | HOH1600 |
| site_id | FC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K G 5074 |
| Chain | Residue |
| G | GLU215 |
| G | ASN236 |
| G | ASP238 |
| G | ALA239 |
| G | ILE242 |
| G | SER247 |
| site_id | FC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE K C 5042 |
| Chain | Residue |
| C | ASP84 |
| C | GLY112 |
| C | THR114 |
| C | HOH1171 |
| site_id | FC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE K G 5075 |
| Chain | Residue |
| G | ALA126 |
| G | GLU127 |
| G | GLU299 |
| G | MET300 |
| G | ASN301 |
| G | HOH5162 |
| G | HOH5256 |
| site_id | GC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE K D 5043 |
| Chain | Residue |
| C | HOH1562 |
| D | HIS16 |
| D | ASP112 |
| D | HOH1561 |
| site_id | GC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN G 5078 |
| Chain | Residue |
| G | GLN829 |
| G | GLU841 |
| G | ADP5077 |
| G | HOH5169 |
| site_id | GC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K C 5044 |
| Chain | Residue |
| C | GLU217 |
| C | THR244 |
| C | ASN283 |
| C | GLN285 |
| C | HOH1160 |
| C | PO45028 |
| site_id | GC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K G 5079 |
| Chain | Residue |
| G | GLU841 |
| G | ASN843 |
| G | ADP5077 |
| G | HOH5607 |
| G | HOH5705 |
| site_id | GC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE K C 5045 |
| Chain | Residue |
| C | THR143 |
| C | ALA144 |
| C | HOH1259 |
| C | HOH1260 |
| site_id | GC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K G 5080 |
| Chain | Residue |
| G | GLU761 |
| G | HIS781 |
| G | GLU783 |
| G | GLN784 |
| G | VAL787 |
| G | SER792 |
| site_id | GC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN E 5047 |
| Chain | Residue |
| E | GLU299 |
| E | ASN301 |
| E | ADP5046 |
| E | MN5048 |
| E | PO45051 |
| E | HOH5140 |
| site_id | GC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL G 5083 |
| Chain | Residue |
| G | GLN93 |
| G | THR173 |
| G | MET174 |
| site_id | GC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN E 5048 |
| Chain | Residue |
| E | GLN285 |
| E | GLU299 |
| E | ADP5046 |
| E | MN5047 |
| E | PO45051 |
| E | HOH5139 |
| site_id | HC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL G 5084 |
| Chain | Residue |
| G | ASN289 |
| G | ASN292 |
| G | ARG294 |
| site_id | HC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K E 5049 |
| Chain | Residue |
| E | GLU215 |
| E | ASN236 |
| E | ASP238 |
| E | ALA239 |
| E | ILE242 |
| E | SER247 |
| site_id | HC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL G 5085 |
| Chain | Residue |
| G | ASN371 |
| G | PHE900 |
| G | PRO901 |
| G | GLY902 |
| G | HOH5313 |
| site_id | HC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE K E 5050 |
| Chain | Residue |
| E | ALA126 |
| E | GLU127 |
| E | GLU299 |
| E | MET300 |
| E | ASN301 |
| E | HOH5233 |
| E | HOH5697 |
| site_id | HC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL G 5086 |
| Chain | Residue |
| G | LYS940 |
| G | LYS941 |
| site_id | HC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN E 5053 |
| Chain | Residue |
| E | GLN829 |
| E | GLU841 |
| E | ADP5052 |
| E | HOH5147 |
| site_id | HC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL G 5087 |
| Chain | Residue |
| G | ARG950 |
| G | GLY952 |
| G | SER1018 |
| site_id | HC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE K E 5054 |
| Chain | Residue |
| E | GLU841 |
| E | ASN843 |
| E | ADP5052 |
| site_id | HC9 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL H 5088 |
| Chain | Residue |
| H | LYS285 |
| site_id | IC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K E 5055 |
| Chain | Residue |
| E | GLU761 |
| E | HIS781 |
| E | GLU783 |
| E | GLN784 |
| E | VAL787 |
| E | SER792 |
| site_id | IC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL H 5089 |
| Chain | Residue |
| G | GLU549 |
| H | PHE15 |
| H | ASP114 |
| site_id | IC3 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE PO4 A 5005 |
| Chain | Residue |
| A | MET174 |
| A | GLY175 |
| A | HIS243 |
| A | GLN285 |
| A | GLU299 |
| A | ASN301 |
| A | ARG303 |
| A | ARG306 |
| A | ADP5000 |
| A | MN5001 |
| A | MN5002 |
| A | K5021 |
| A | HOH5157 |
| A | HOH5159 |
| A | HOH5161 |
| site_id | IC4 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE PO4 C 5028 |
| Chain | Residue |
| C | MET174 |
| C | GLY175 |
| C | HIS243 |
| C | GLN285 |
| C | GLU299 |
| C | ASN301 |
| C | ARG303 |
| C | ARG306 |
| C | HOH1158 |
| C | HOH1160 |
| C | ADP5023 |
| C | MN5024 |
| C | MN5025 |
| C | K5044 |
| site_id | IC5 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE PO4 E 5051 |
| Chain | Residue |
| E | MET174 |
| E | GLY175 |
| E | HIS243 |
| E | GLN285 |
| E | GLU299 |
| E | ASN301 |
| E | ARG303 |
| E | ARG306 |
| E | ADP5046 |
| E | MN5047 |
| E | MN5048 |
| E | K5067 |
| E | HOH5141 |
| E | HOH5143 |
| site_id | IC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 E 5070 |
| Chain | Residue |
| E | PRO797 |
| E | PRO885 |
| E | PRO886 |
| E | TYR888 |
| site_id | IC7 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE PO4 G 5076 |
| Chain | Residue |
| G | MET174 |
| G | GLY175 |
| G | HIS243 |
| G | GLN285 |
| G | GLU299 |
| G | ASN301 |
| G | ARG303 |
| G | ARG306 |
| G | ADP5071 |
| G | MN5072 |
| G | MN5073 |
| G | K5092 |
| G | HOH5163 |
| site_id | IC8 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE ADP A 5000 |
| Chain | Residue |
| A | ARG129 |
| A | ILE167 |
| A | ARG169 |
| A | MET174 |
| A | GLY175 |
| A | GLY176 |
| A | GLU208 |
| A | LEU210 |
| A | ILE211 |
| A | GLU215 |
| A | MET240 |
| A | GLY241 |
| A | ILE242 |
| A | HIS243 |
| A | THR244 |
| A | GLN285 |
| A | ILE298 |
| A | GLU299 |
| A | THR376 |
| A | MN5001 |
| A | MN5002 |
| A | PO45005 |
| A | HOH5151 |
| A | HOH5157 |
| A | HOH5158 |
| A | HOH5714 |
| site_id | IC9 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE ADP A 5006 |
| Chain | Residue |
| A | ARG715 |
| A | MET725 |
| A | HIS754 |
| A | PHE755 |
| A | LEU756 |
| A | GLU761 |
| A | ALA785 |
| A | GLY786 |
| A | VAL787 |
| A | HIS788 |
| A | SER789 |
| A | GLN829 |
| A | GLU841 |
| A | MN5007 |
| A | K5008 |
| A | HOH5165 |
| A | HOH5613 |
| A | HOH5948 |
| site_id | JC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE ORN A 5010 |
| Chain | Residue |
| A | GLU783 |
| A | ASP791 |
| A | ALA793 |
| A | GLU892 |
| A | LEU907 |
| A | TYR1040 |
| A | ASP1041 |
| A | THR1042 |
| A | HOH5095 |
| A | HOH5100 |
| site_id | JC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NET A 5094 |
| Chain | Residue |
| A | GLN22 |
| A | THR94 |
| A | ASN97 |
| A | ASN936 |
| site_id | JC3 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE ADP C 5023 |
| Chain | Residue |
| C | ARG129 |
| C | ILE167 |
| C | ARG169 |
| C | THR173 |
| C | MET174 |
| C | GLY175 |
| C | GLY176 |
| C | GLU208 |
| C | SER209 |
| C | LEU210 |
| C | ILE211 |
| C | GLU215 |
| C | MET240 |
| C | GLY241 |
| C | ILE242 |
| C | HIS243 |
| C | THR244 |
| C | GLN285 |
| C | ILE298 |
| C | GLU299 |
| C | THR376 |
| C | HOH1150 |
| C | HOH1156 |
| C | HOH1157 |
| C | HOH1848 |
| C | MN5024 |
| C | MN5025 |
| C | PO45028 |
| site_id | JC4 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE ADP C 5029 |
| Chain | Residue |
| C | ARG715 |
| C | MET725 |
| C | HIS754 |
| C | PHE755 |
| C | LEU756 |
| C | GLU761 |
| C | ALA785 |
| C | GLY786 |
| C | VAL787 |
| C | HIS788 |
| C | SER789 |
| C | GLN829 |
| C | GLU841 |
| C | HOH1164 |
| C | HOH1651 |
| C | HOH1852 |
| C | MN5030 |
| C | K5031 |
| site_id | JC5 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE ORN C 5033 |
| Chain | Residue |
| C | GLU783 |
| C | ASP791 |
| C | GLU892 |
| C | VAL893 |
| C | LEU907 |
| C | TYR1040 |
| C | ASP1041 |
| C | THR1042 |
| C | HOH1094 |
| C | HOH1099 |
| site_id | JC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NET C 5034 |
| Chain | Residue |
| C | THR94 |
| C | ASN97 |
| C | ASN936 |
| site_id | JC7 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE ADP E 5046 |
| Chain | Residue |
| E | ARG129 |
| E | ILE167 |
| E | ARG169 |
| E | THR173 |
| E | MET174 |
| E | GLY175 |
| E | GLY176 |
| E | GLU208 |
| E | LEU210 |
| E | ILE211 |
| E | GLU215 |
| E | MET240 |
| E | GLY241 |
| E | ILE242 |
| E | HIS243 |
| E | THR244 |
| E | GLN285 |
| E | ILE298 |
| E | GLU299 |
| E | THR376 |
| E | MN5047 |
| E | MN5048 |
| E | PO45051 |
| E | HOH5133 |
| E | HOH5139 |
| E | HOH5140 |
| E | HOH5698 |
| site_id | JC8 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE ADP E 5052 |
| Chain | Residue |
| E | ARG715 |
| E | MET725 |
| E | HIS754 |
| E | PHE755 |
| E | LEU756 |
| E | GLU761 |
| E | ALA785 |
| E | GLY786 |
| E | VAL787 |
| E | HIS788 |
| E | SER789 |
| E | GLN829 |
| E | GLU841 |
| E | MN5053 |
| E | K5054 |
| E | HOH5146 |
| E | HOH5147 |
| E | HOH5589 |
| site_id | JC9 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE ORN E 5056 |
| Chain | Residue |
| E | GLU783 |
| E | ASP791 |
| E | ALA793 |
| E | GLU892 |
| E | LEU907 |
| E | TYR1040 |
| E | ASP1041 |
| E | THR1042 |
| E | HOH5077 |
| E | HOH5079 |
| E | HOH5082 |
| site_id | KC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE NET E 5057 |
| Chain | Residue |
| E | GLN22 |
| E | THR94 |
| site_id | KC2 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE ADP G 5071 |
| Chain | Residue |
| G | ARG129 |
| G | ILE167 |
| G | ARG169 |
| G | THR173 |
| G | MET174 |
| G | GLY175 |
| G | GLY176 |
| G | GLU208 |
| G | LEU210 |
| G | ILE211 |
| G | GLU215 |
| G | MET240 |
| G | GLY241 |
| G | ILE242 |
| G | HIS243 |
| G | THR244 |
| G | GLN285 |
| G | ILE298 |
| G | GLU299 |
| G | THR376 |
| G | MN5072 |
| G | MN5073 |
| G | PO45076 |
| G | HOH5155 |
| G | HOH5161 |
| G | HOH5162 |
| G | HOH5703 |
| site_id | KC3 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE ADP G 5077 |
| Chain | Residue |
| G | ARG715 |
| G | MET725 |
| G | HIS754 |
| G | PHE755 |
| G | LEU756 |
| G | GLU761 |
| G | ALA785 |
| G | GLY786 |
| G | VAL787 |
| G | HIS788 |
| G | SER789 |
| G | GLN829 |
| G | GLU841 |
| G | MN5078 |
| G | K5079 |
| G | HOH5169 |
| G | HOH5170 |
| G | HOH5573 |
| G | HOH5607 |
| site_id | KC4 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE ORN G 5081 |
| Chain | Residue |
| G | GLU783 |
| G | ASP791 |
| G | ALA793 |
| G | GLU892 |
| G | VAL893 |
| G | LEU907 |
| G | TYR1040 |
| G | ASP1041 |
| G | THR1042 |
| G | HOH5099 |
| G | HOH5101 |
| G | HOH5104 |
| site_id | KC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NET G 5082 |
| Chain | Residue |
| G | GLN22 |
| G | THR94 |
| G | ASN97 |
Functional Information from PROSITE/UniProt
| site_id | PS00866 |
| Number of Residues | 15 |
| Details | CPSASE_1 Carbamoyl-phosphate synthase subdomain signature 1. FPCIIRPSftmGGsG |
| Chain | Residue | Details |
| A | PHE164-GLY178 | |
| A | TYR710-ALA724 |
| site_id | PS00867 |
| Number of Residues | 8 |
| Details | CPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. VIEMNPRV |
| Chain | Residue | Details |
| A | VAL297-VAL304 | |
| A | LEU839-ALA846 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 |
| Chain | Residue | Details |
| B | CYG269 | |
| A | HIS243 | |
| A | ARG715 | |
| A | HIS754 | |
| A | LEU756 | |
| A | GLU761 | |
| A | GLY786 | |
| A | VAL787 | |
| A | HIS788 | |
| A | SER789 | |
| C | ARG129 | |
| D | CYG269 | |
| C | ARG169 | |
| C | GLY175 | |
| C | GLY176 | |
| C | GLU208 | |
| C | LEU210 | |
| C | GLU215 | |
| C | GLY241 | |
| C | ILE242 | |
| C | HIS243 | |
| C | ARG715 | |
| F | CYG269 | |
| C | HIS754 | |
| C | LEU756 | |
| C | GLU761 | |
| C | GLY786 | |
| C | VAL787 | |
| C | HIS788 | |
| C | SER789 | |
| E | ARG129 | |
| E | ARG169 | |
| E | GLY175 | |
| H | CYG269 | |
| E | GLY176 | |
| E | GLU208 | |
| E | LEU210 | |
| E | GLU215 | |
| E | GLY241 | |
| E | ILE242 | |
| E | HIS243 | |
| E | ARG715 | |
| E | HIS754 | |
| E | LEU756 | |
| A | GLU208 | |
| E | GLU761 | |
| E | GLY786 | |
| E | VAL787 | |
| E | HIS788 | |
| E | SER789 | |
| G | ARG129 | |
| G | ARG169 | |
| G | GLY175 | |
| G | GLY176 | |
| G | GLU208 | |
| A | LEU210 | |
| G | LEU210 | |
| G | GLU215 | |
| G | GLY241 | |
| G | ILE242 | |
| G | HIS243 | |
| G | ARG715 | |
| G | HIS754 | |
| G | LEU756 | |
| G | GLU761 | |
| G | GLY786 | |
| A | GLU215 | |
| G | VAL787 | |
| G | HIS788 | |
| G | SER789 | |
| A | GLY241 | |
| A | ILE242 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_01209 |
| Chain | Residue | Details |
| B | HIS353 | |
| B | GLU355 | |
| D | HIS353 | |
| D | GLU355 | |
| F | HIS353 | |
| F | GLU355 | |
| H | HIS353 | |
| H | GLU355 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 32 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01209, ECO:0000269|PubMed:10587438, ECO:0007744|PDB:1C3O |
| Chain | Residue | Details |
| B | SER47 | |
| D | GLY241 | |
| D | GLY243 | |
| D | LEU270 | |
| D | GLN273 | |
| D | ASN311 | |
| D | GLY313 | |
| D | PHE314 | |
| F | SER47 | |
| F | GLY241 | |
| F | GLY243 | |
| B | GLY241 | |
| F | LEU270 | |
| F | GLN273 | |
| F | ASN311 | |
| F | GLY313 | |
| F | PHE314 | |
| H | SER47 | |
| H | GLY241 | |
| H | GLY243 | |
| H | LEU270 | |
| H | GLN273 | |
| B | GLY243 | |
| H | ASN311 | |
| H | GLY313 | |
| H | PHE314 | |
| B | LEU270 | |
| B | GLN273 | |
| B | ASN311 | |
| B | GLY313 | |
| B | PHE314 | |
| D | SER47 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01210, ECO:0000269|PubMed:10428826, ECO:0000269|PubMed:9636022, ECO:0007744|PDB:1CE8 |
| Chain | Residue | Details |
| A | GLN829 | |
| C | GLN829 | |
| E | GLN829 | |
| G | GLN829 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01210, ECO:0000269|PubMed:10029528, ECO:0000269|PubMed:10089390, ECO:0000269|PubMed:10428826, ECO:0000269|PubMed:9636022, ECO:0007744|PDB:1CE8 |
| Chain | Residue | Details |
| A | GLU841 | |
| C | GLU841 | |
| E | GLU841 | |
| G | GLU841 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01210, ECO:0000269|PubMed:10029528, ECO:0000269|PubMed:10089390 |
| Chain | Residue | Details |
| A | ASN843 | |
| C | ASN843 | |
| E | ASN843 | |
| G | ASN843 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1bxr |
| Chain | Residue | Details |
| B | HIS353 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1bxr |
| Chain | Residue | Details |
| D | HIS353 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1bxr |
| Chain | Residue | Details |
| F | HIS353 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1bxr |
| Chain | Residue | Details |
| H | HIS353 |
| site_id | CSA5 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1bxr |
| Chain | Residue | Details |
| B | HIS353 | |
| B | CYG269 | |
| B | GLU355 |
| site_id | CSA6 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1bxr |
| Chain | Residue | Details |
| D | HIS353 | |
| D | CYG269 | |
| D | GLU355 |
| site_id | CSA7 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1bxr |
| Chain | Residue | Details |
| F | HIS353 | |
| F | CYG269 | |
| F | GLU355 |
| site_id | CSA8 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1bxr |
| Chain | Residue | Details |
| H | HIS353 | |
| H | CYG269 | |
| H | GLU355 |
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 435 |
| Chain | Residue | Details |
| B | CYG269 | covalent catalysis, proton shuttle (general acid/base) |
| A | ARG303 | electrostatic stabiliser |
| A | ARG715 | electrostatic stabiliser |
| A | GLY721 | electrostatic stabiliser |
| A | GLY722 | electrostatic stabiliser |
| A | GLU761 | steric role |
| A | GLN829 | metal ligand |
| A | GLU841 | metal ligand |
| A | ASN843 | metal ligand |
| A | ARG848 | electrostatic stabiliser |
| B | HIS353 | proton shuttle (general acid/base) |
| B | GLU355 | steric role |
| A | GLU215 | steric role |
| A | HIS243 | proton shuttle (general acid/base) |
| A | ASN283 | electrostatic stabiliser |
| A | GLN285 | metal ligand |
| A | GLU299 | metal ligand |
| A | ASN301 | metal ligand |
| site_id | MCSA2 |
| Number of Residues | 3 |
| Details | M-CSA 435 |
| Chain | Residue | Details |
| D | CYG269 | covalent catalysis, proton shuttle (general acid/base) |
| C | ARG303 | electrostatic stabiliser |
| C | ARG715 | electrostatic stabiliser |
| C | GLY721 | electrostatic stabiliser |
| C | GLY722 | electrostatic stabiliser |
| C | GLU761 | steric role |
| C | GLN829 | metal ligand |
| C | GLU841 | metal ligand |
| C | ASN843 | metal ligand |
| C | ARG848 | electrostatic stabiliser |
| D | HIS353 | proton shuttle (general acid/base) |
| D | GLU355 | steric role |
| C | GLU215 | steric role |
| C | HIS243 | proton shuttle (general acid/base) |
| C | ASN283 | electrostatic stabiliser |
| C | GLN285 | metal ligand |
| C | GLU299 | metal ligand |
| C | ASN301 | metal ligand |
| site_id | MCSA3 |
| Number of Residues | 3 |
| Details | M-CSA 435 |
| Chain | Residue | Details |
| F | CYG269 | covalent catalysis, proton shuttle (general acid/base) |
| E | ARG303 | electrostatic stabiliser |
| E | ARG715 | electrostatic stabiliser |
| E | GLY721 | electrostatic stabiliser |
| E | GLY722 | electrostatic stabiliser |
| E | GLU761 | steric role |
| E | GLN829 | metal ligand |
| E | GLU841 | metal ligand |
| E | ASN843 | metal ligand |
| E | ARG848 | electrostatic stabiliser |
| F | HIS353 | proton shuttle (general acid/base) |
| F | GLU355 | steric role |
| E | GLU215 | steric role |
| E | HIS243 | proton shuttle (general acid/base) |
| E | ASN283 | electrostatic stabiliser |
| E | GLN285 | metal ligand |
| E | GLU299 | metal ligand |
| E | ASN301 | metal ligand |
| site_id | MCSA4 |
| Number of Residues | 3 |
| Details | M-CSA 435 |
| Chain | Residue | Details |
| H | CYG269 | covalent catalysis, proton shuttle (general acid/base) |
| G | ARG303 | electrostatic stabiliser |
| G | ARG715 | electrostatic stabiliser |
| G | GLY721 | electrostatic stabiliser |
| G | GLY722 | electrostatic stabiliser |
| G | GLU761 | steric role |
| G | GLN829 | metal ligand |
| G | GLU841 | metal ligand |
| G | ASN843 | metal ligand |
| G | ARG848 | electrostatic stabiliser |
| H | HIS353 | proton shuttle (general acid/base) |
| H | GLU355 | steric role |
| G | GLU215 | steric role |
| G | HIS243 | proton shuttle (general acid/base) |
| G | ASN283 | electrostatic stabiliser |
| G | GLN285 | metal ligand |
| G | GLU299 | metal ligand |
| G | ASN301 | metal ligand |
