Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1CS0

Crystal structure of carbamoyl phosphate synthetase complexed at CYS269 in the small subunit with the tetrahedral mimic l-glutamate gamma-semialdehyde

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004087	molecular_function	carbamoyl-phosphate synthase (ammonia) activity
A	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005951	cellular_component	carbamoyl-phosphate synthase complex
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0006526	biological_process	L-arginine biosynthetic process
A	0006541	biological_process	glutamine metabolic process
A	0008652	biological_process	amino acid biosynthetic process
A	0009064	biological_process	glutamine family amino acid metabolic process
A	0016597	molecular_function	amino acid binding
A	0016874	molecular_function	ligase activity
A	0016879	molecular_function	ligase activity, forming carbon-nitrogen bonds
A	0019856	biological_process	pyrimidine nucleobase biosynthetic process
A	0044205	biological_process	'de novo' UMP biosynthetic process
A	0046872	molecular_function	metal ion binding
B	0000166	molecular_function	nucleotide binding
B	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B	0004359	molecular_function	glutaminase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005951	cellular_component	carbamoyl-phosphate synthase complex
B	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0006526	biological_process	L-arginine biosynthetic process
B	0006541	biological_process	glutamine metabolic process
B	0008652	biological_process	amino acid biosynthetic process
B	0016874	molecular_function	ligase activity
B	0019856	biological_process	pyrimidine nucleobase biosynthetic process
B	0044205	biological_process	'de novo' UMP biosynthetic process
B	0046982	molecular_function	protein heterodimerization activity
C	0000166	molecular_function	nucleotide binding
C	0004087	molecular_function	carbamoyl-phosphate synthase (ammonia) activity
C	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005951	cellular_component	carbamoyl-phosphate synthase complex
C	0006221	biological_process	pyrimidine nucleotide biosynthetic process
C	0006526	biological_process	L-arginine biosynthetic process
C	0006541	biological_process	glutamine metabolic process
C	0008652	biological_process	amino acid biosynthetic process
C	0009064	biological_process	glutamine family amino acid metabolic process
C	0016597	molecular_function	amino acid binding
C	0016874	molecular_function	ligase activity
C	0016879	molecular_function	ligase activity, forming carbon-nitrogen bonds
C	0019856	biological_process	pyrimidine nucleobase biosynthetic process
C	0044205	biological_process	'de novo' UMP biosynthetic process
C	0046872	molecular_function	metal ion binding
D	0000166	molecular_function	nucleotide binding
D	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D	0004359	molecular_function	glutaminase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005951	cellular_component	carbamoyl-phosphate synthase complex
D	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
D	0006221	biological_process	pyrimidine nucleotide biosynthetic process
D	0006526	biological_process	L-arginine biosynthetic process
D	0006541	biological_process	glutamine metabolic process
D	0008652	biological_process	amino acid biosynthetic process
D	0016874	molecular_function	ligase activity
D	0019856	biological_process	pyrimidine nucleobase biosynthetic process
D	0044205	biological_process	'de novo' UMP biosynthetic process
D	0046982	molecular_function	protein heterodimerization activity
E	0000166	molecular_function	nucleotide binding
E	0004087	molecular_function	carbamoyl-phosphate synthase (ammonia) activity
E	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005951	cellular_component	carbamoyl-phosphate synthase complex
E	0006221	biological_process	pyrimidine nucleotide biosynthetic process
E	0006526	biological_process	L-arginine biosynthetic process
E	0006541	biological_process	glutamine metabolic process
E	0008652	biological_process	amino acid biosynthetic process
E	0009064	biological_process	glutamine family amino acid metabolic process
E	0016597	molecular_function	amino acid binding
E	0016874	molecular_function	ligase activity
E	0016879	molecular_function	ligase activity, forming carbon-nitrogen bonds
E	0019856	biological_process	pyrimidine nucleobase biosynthetic process
E	0044205	biological_process	'de novo' UMP biosynthetic process
E	0046872	molecular_function	metal ion binding
F	0000166	molecular_function	nucleotide binding
F	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F	0004359	molecular_function	glutaminase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005951	cellular_component	carbamoyl-phosphate synthase complex
F	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
F	0006221	biological_process	pyrimidine nucleotide biosynthetic process
F	0006526	biological_process	L-arginine biosynthetic process
F	0006541	biological_process	glutamine metabolic process
F	0008652	biological_process	amino acid biosynthetic process
F	0016874	molecular_function	ligase activity
F	0019856	biological_process	pyrimidine nucleobase biosynthetic process
F	0044205	biological_process	'de novo' UMP biosynthetic process
F	0046982	molecular_function	protein heterodimerization activity
G	0000166	molecular_function	nucleotide binding
G	0004087	molecular_function	carbamoyl-phosphate synthase (ammonia) activity
G	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005951	cellular_component	carbamoyl-phosphate synthase complex
G	0006221	biological_process	pyrimidine nucleotide biosynthetic process
G	0006526	biological_process	L-arginine biosynthetic process
G	0006541	biological_process	glutamine metabolic process
G	0008652	biological_process	amino acid biosynthetic process
G	0009064	biological_process	glutamine family amino acid metabolic process
G	0016597	molecular_function	amino acid binding
G	0016874	molecular_function	ligase activity
G	0016879	molecular_function	ligase activity, forming carbon-nitrogen bonds
G	0019856	biological_process	pyrimidine nucleobase biosynthetic process
G	0044205	biological_process	'de novo' UMP biosynthetic process
G	0046872	molecular_function	metal ion binding
H	0000166	molecular_function	nucleotide binding
H	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H	0004359	molecular_function	glutaminase activity
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005951	cellular_component	carbamoyl-phosphate synthase complex
H	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
H	0006221	biological_process	pyrimidine nucleotide biosynthetic process
H	0006526	biological_process	L-arginine biosynthetic process
H	0006541	biological_process	glutamine metabolic process
H	0008652	biological_process	amino acid biosynthetic process
H	0016874	molecular_function	ligase activity
H	0019856	biological_process	pyrimidine nucleobase biosynthetic process
H	0044205	biological_process	'de novo' UMP biosynthetic process
H	0046982	molecular_function	protein heterodimerization activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN A 5001

Chain	Residue
A	GLU299
A	ASN301
A	ADP5000
A	MN5002
A	PO45005
A	HOH5158

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MN A 5002

Chain	Residue
A	MN5001
A	PO45005
A	K5021
A	HOH5157
A	GLN285
A	GLU299
A	ADP5000

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K A 5003

Chain	Residue
A	GLU215
A	ASN236
A	ASP238
A	ALA239
A	ILE242
A	SER247

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE K A 5004

Chain	Residue
A	ALA126
A	GLU127
A	GLU299
A	MET300
A	ASN301
A	HOH5158
A	HOH5252
A	HOH5912

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN A 5007

Chain	Residue
A	GLN829
A	GLU841
A	ADP5006
A	HOH5165
A	HOH5948

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K A 5008

Chain	Residue
A	GLU841
A	ASN843
A	ADP5006

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K A 5009

Chain	Residue
A	GLU761
A	HIS781
A	GLU783
A	GLN784
A	VAL787
A	SER792

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL A 5011

Chain	Residue
A	GLN93
A	THR173
A	MET174
A	HOH5133
A	HOH5134

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 5012

Chain	Residue
A	ASN289
A	ASN292
A	ARG294

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 5013

Chain	Residue
A	ASN371
A	PHE900
A	PRO901
A	GLY902

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 5014

Chain	Residue
A	LYS940
A	LYS941
A	HIS942

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 5015

Chain	Residue
A	ARG950
A	GLY952
A	SER1018

site_id	BC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL B 5016

Chain	Residue
B	LYS285

site_id	BC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL B 5017

Chain	Residue
B	ASP114
B	HOH5058

site_id	BC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 5018

Chain	Residue
A	ARG294
A	HOH5711

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K A 5019

Chain	Residue
A	ASP84
A	GLY112
A	THR114
A	HOH5172
A	HOH5173
A	HOH5730

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K B 5020

Chain	Residue
B	HIS16
B	ASP112
B	HOH5057
B	HOH5058

site_id	BC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE K A 5021

Chain	Residue
A	GLU217
A	THR244
A	ASN283
A	GLN285
A	MN5002
A	PO45005
A	HOH5161

site_id	CC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K A 5022

Chain	Residue
A	THR143
A	ALA144
A	HOH5261

site_id	CC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL E 5058

Chain	Residue
E	GLN93
E	THR173
E	MET174
E	HOH5116

site_id	CC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K G 5090

Chain	Residue
G	ASP84
G	GLY112
G	THR114
G	HOH5177
G	HOH5715

site_id	CC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN C 5024

Chain	Residue
C	GLU299
C	ASN301
C	HOH1157
C	ADP5023
C	MN5025
C	PO45028

site_id	CC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL E 5059

Chain	Residue
E	ASN289
E	ASN292
E	ARG294

site_id	CC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K H 5091

Chain	Residue
G	HOH5530
H	HIS16
H	ASP112

site_id	CC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN C 5025

Chain	Residue
C	GLN285
C	GLU299
C	HOH1156
C	ADP5023
C	MN5024
C	PO45028

site_id	CC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL E 5060

Chain	Residue
E	ASN371
E	PHE900
E	PRO901
E	GLY902

site_id	CC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE K G 5092

Chain	Residue
G	GLU217
G	THR244
G	ASN283
G	GLN285
G	MN5073
G	PO45076
G	HOH5165

site_id	DC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K C 5026

Chain	Residue
C	GLU215
C	ASN236
C	ASP238
C	ALA239
C	ILE242
C	SER247

site_id	DC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL E 5061

Chain	Residue
E	LYS941

site_id	DC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K G 5093

Chain	Residue
G	THR143
G	ALA144
G	HOH5265
G	HOH5266

site_id	DC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE K C 5027

Chain	Residue
C	ALA126
C	GLU127
C	GLU299
C	MET300
C	ASN301
C	HOH1250
C	HOH1849

site_id	DC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL E 5062

Chain	Residue
E	ARG950
E	GLU951
E	GLY952

site_id	DC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN C 5030

Chain	Residue
C	GLN829
C	GLU841
C	HOH1164
C	HOH1851
C	ADP5029

site_id	DC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL F 5063

Chain	Residue
F	LYS285

site_id	DC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K C 5031

Chain	Residue
C	GLU841
C	ASN843
C	HOH1651
C	ADP5029

site_id	DC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL F 5064

Chain	Residue
F	PHE15
F	ASP114
F	HOH2657

site_id	EC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K C 5032

Chain	Residue
C	GLU761
C	HIS781
C	GLU783
C	GLN784
C	VAL787
C	SER792

site_id	EC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K E 5065

Chain	Residue
E	ASP84
E	GLY112
E	THR114
E	HOH5704

site_id	EC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL C 5035

Chain	Residue
C	GLN93
C	THR173
C	MET174
C	HOH1132

site_id	EC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K F 5066

Chain	Residue
E	HOH5511
F	HIS16
F	ASP112
F	HOH2618

site_id	EC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL C 5036

Chain	Residue
C	ASN289
C	ASN292
C	ARG294

site_id	EC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K E 5067

Chain	Residue
E	GLU217
E	THR244
E	ASN283
E	GLN285
E	PO45051
E	HOH5143

site_id	EC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL C 5037

Chain	Residue
C	ALA370
C	ASN371
C	PHE900
C	PRO901
C	GLY902

site_id	EC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE K E 5068

Chain	Residue
E	THR279

site_id	EC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL C 5038

Chain	Residue
C	LYS940
C	LYS941

site_id	FC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K E 5069

Chain	Residue
E	THR143
E	ALA144
E	HOH5243

site_id	FC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL C 5039

Chain	Residue
C	ARG950
C	SER1018

site_id	FC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN G 5072

Chain	Residue
G	GLU299
G	ASN301
G	ADP5071
G	MN5073
G	PO45076
G	HOH5162

site_id	FC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL D 5040

Chain	Residue
D	LYS285

site_id	FC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MN G 5073

Chain	Residue
G	GLN285
G	GLU299
G	ADP5071
G	MN5072
G	PO45076
G	K5092
G	HOH5161

site_id	FC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL D 5041

Chain	Residue
C	GLU549
C	HOH1562
D	PHE15
D	ASP114
D	HOH1600

site_id	FC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K G 5074

Chain	Residue
G	GLU215
G	ASN236
G	ASP238
G	ALA239
G	ILE242
G	SER247

site_id	FC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K C 5042

Chain	Residue
C	ASP84
C	GLY112
C	THR114
C	HOH1171

site_id	FC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE K G 5075

Chain	Residue
G	ALA126
G	GLU127
G	GLU299
G	MET300
G	ASN301
G	HOH5162
G	HOH5256

site_id	GC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K D 5043

Chain	Residue
C	HOH1562
D	HIS16
D	ASP112
D	HOH1561

site_id	GC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN G 5078

Chain	Residue
G	GLN829
G	GLU841
G	ADP5077
G	HOH5169

site_id	GC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K C 5044

Chain	Residue
C	GLU217
C	THR244
C	ASN283
C	GLN285
C	HOH1160
C	PO45028

site_id	GC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K G 5079

Chain	Residue
G	GLU841
G	ASN843
G	ADP5077
G	HOH5607
G	HOH5705

site_id	GC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K C 5045

Chain	Residue
C	THR143
C	ALA144
C	HOH1259
C	HOH1260

site_id	GC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K G 5080

Chain	Residue
G	GLU761
G	HIS781
G	GLU783
G	GLN784
G	VAL787
G	SER792

site_id	GC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN E 5047

Chain	Residue
E	GLU299
E	ASN301
E	ADP5046
E	MN5048
E	PO45051
E	HOH5140

site_id	GC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL G 5083

Chain	Residue
G	GLN93
G	THR173
G	MET174

site_id	GC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN E 5048

Chain	Residue
E	GLN285
E	GLU299
E	ADP5046
E	MN5047
E	PO45051
E	HOH5139

site_id	HC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL G 5084

Chain	Residue
G	ASN289
G	ASN292
G	ARG294

site_id	HC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K E 5049

Chain	Residue
E	GLU215
E	ASN236
E	ASP238
E	ALA239
E	ILE242
E	SER247

site_id	HC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL G 5085

Chain	Residue
G	ASN371
G	PHE900
G	PRO901
G	GLY902
G	HOH5313

site_id	HC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE K E 5050

Chain	Residue
E	ALA126
E	GLU127
E	GLU299
E	MET300
E	ASN301
E	HOH5233
E	HOH5697

site_id	HC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL G 5086

Chain	Residue
G	LYS940
G	LYS941

site_id	HC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN E 5053

Chain	Residue
E	GLN829
E	GLU841
E	ADP5052
E	HOH5147

site_id	HC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL G 5087

Chain	Residue
G	ARG950
G	GLY952
G	SER1018

site_id	HC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K E 5054

Chain	Residue
E	GLU841
E	ASN843
E	ADP5052

site_id	HC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL H 5088

Chain	Residue
H	LYS285

site_id	IC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K E 5055

Chain	Residue
E	GLU761
E	HIS781
E	GLU783
E	GLN784
E	VAL787
E	SER792

site_id	IC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL H 5089

Chain	Residue
G	GLU549
H	PHE15
H	ASP114

site_id	IC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE PO4 A 5005

Chain	Residue
A	MET174
A	GLY175
A	HIS243
A	GLN285
A	GLU299
A	ASN301
A	ARG303
A	ARG306
A	ADP5000
A	MN5001
A	MN5002
A	K5021
A	HOH5157
A	HOH5159
A	HOH5161

site_id	IC4
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PO4 C 5028

Chain	Residue
C	MET174
C	GLY175
C	HIS243
C	GLN285
C	GLU299
C	ASN301
C	ARG303
C	ARG306
C	HOH1158
C	HOH1160
C	ADP5023
C	MN5024
C	MN5025
C	K5044

site_id	IC5
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PO4 E 5051

Chain	Residue
E	MET174
E	GLY175
E	HIS243
E	GLN285
E	GLU299
E	ASN301
E	ARG303
E	ARG306
E	ADP5046
E	MN5047
E	MN5048
E	K5067
E	HOH5141
E	HOH5143

site_id	IC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 E 5070

Chain	Residue
E	PRO797
E	PRO885
E	PRO886
E	TYR888

site_id	IC7
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PO4 G 5076

Chain	Residue
G	MET174
G	GLY175
G	HIS243
G	GLN285
G	GLU299
G	ASN301
G	ARG303
G	ARG306
G	ADP5071
G	MN5072
G	MN5073
G	K5092
G	HOH5163

site_id	IC8
Number of Residues	26
Details	BINDING SITE FOR RESIDUE ADP A 5000

Chain	Residue
A	ARG129
A	ILE167
A	ARG169
A	MET174
A	GLY175
A	GLY176
A	GLU208
A	LEU210
A	ILE211
A	GLU215
A	MET240
A	GLY241
A	ILE242
A	HIS243
A	THR244
A	GLN285
A	ILE298
A	GLU299
A	THR376
A	MN5001
A	MN5002
A	PO45005
A	HOH5151
A	HOH5157
A	HOH5158
A	HOH5714

site_id	IC9
Number of Residues	18
Details	BINDING SITE FOR RESIDUE ADP A 5006

Chain	Residue
A	ARG715
A	MET725
A	HIS754
A	PHE755
A	LEU756
A	GLU761
A	ALA785
A	GLY786
A	VAL787
A	HIS788
A	SER789
A	GLN829
A	GLU841
A	MN5007
A	K5008
A	HOH5165
A	HOH5613
A	HOH5948

site_id	JC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE ORN A 5010

Chain	Residue
A	GLU783
A	ASP791
A	ALA793
A	GLU892
A	LEU907
A	TYR1040
A	ASP1041
A	THR1042
A	HOH5095
A	HOH5100

site_id	JC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NET A 5094

Chain	Residue
A	GLN22
A	THR94
A	ASN97
A	ASN936

site_id	JC3
Number of Residues	28
Details	BINDING SITE FOR RESIDUE ADP C 5023

Chain	Residue
C	ARG129
C	ILE167
C	ARG169
C	THR173
C	MET174
C	GLY175
C	GLY176
C	GLU208
C	SER209
C	LEU210
C	ILE211
C	GLU215
C	MET240
C	GLY241
C	ILE242
C	HIS243
C	THR244
C	GLN285
C	ILE298
C	GLU299
C	THR376
C	HOH1150
C	HOH1156
C	HOH1157
C	HOH1848
C	MN5024
C	MN5025
C	PO45028

site_id	JC4
Number of Residues	18
Details	BINDING SITE FOR RESIDUE ADP C 5029

Chain	Residue
C	ARG715
C	MET725
C	HIS754
C	PHE755
C	LEU756
C	GLU761
C	ALA785
C	GLY786
C	VAL787
C	HIS788
C	SER789
C	GLN829
C	GLU841
C	HOH1164
C	HOH1651
C	HOH1852
C	MN5030
C	K5031

site_id	JC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE ORN C 5033

Chain	Residue
C	GLU783
C	ASP791
C	GLU892
C	VAL893
C	LEU907
C	TYR1040
C	ASP1041
C	THR1042
C	HOH1094
C	HOH1099

site_id	JC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NET C 5034

Chain	Residue
C	THR94
C	ASN97
C	ASN936

site_id	JC7
Number of Residues	27
Details	BINDING SITE FOR RESIDUE ADP E 5046

Chain	Residue
E	ARG129
E	ILE167
E	ARG169
E	THR173
E	MET174
E	GLY175
E	GLY176
E	GLU208
E	LEU210
E	ILE211
E	GLU215
E	MET240
E	GLY241
E	ILE242
E	HIS243
E	THR244
E	GLN285
E	ILE298
E	GLU299
E	THR376
E	MN5047
E	MN5048
E	PO45051
E	HOH5133
E	HOH5139
E	HOH5140
E	HOH5698

site_id	JC8
Number of Residues	18
Details	BINDING SITE FOR RESIDUE ADP E 5052

Chain	Residue
E	ARG715
E	MET725
E	HIS754
E	PHE755
E	LEU756
E	GLU761
E	ALA785
E	GLY786
E	VAL787
E	HIS788
E	SER789
E	GLN829
E	GLU841
E	MN5053
E	K5054
E	HOH5146
E	HOH5147
E	HOH5589

site_id	JC9
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ORN E 5056

Chain	Residue
E	GLU783
E	ASP791
E	ALA793
E	GLU892
E	LEU907
E	TYR1040
E	ASP1041
E	THR1042
E	HOH5077
E	HOH5079
E	HOH5082

site_id	KC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NET E 5057

Chain	Residue
E	GLN22
E	THR94

site_id	KC2
Number of Residues	27
Details	BINDING SITE FOR RESIDUE ADP G 5071

Chain	Residue
G	ARG129
G	ILE167
G	ARG169
G	THR173
G	MET174
G	GLY175
G	GLY176
G	GLU208
G	LEU210
G	ILE211
G	GLU215
G	MET240
G	GLY241
G	ILE242
G	HIS243
G	THR244
G	GLN285
G	ILE298
G	GLU299
G	THR376
G	MN5072
G	MN5073
G	PO45076
G	HOH5155
G	HOH5161
G	HOH5162
G	HOH5703

site_id	KC3
Number of Residues	19
Details	BINDING SITE FOR RESIDUE ADP G 5077

Chain	Residue
G	ARG715
G	MET725
G	HIS754
G	PHE755
G	LEU756
G	GLU761
G	ALA785
G	GLY786
G	VAL787
G	HIS788
G	SER789
G	GLN829
G	GLU841
G	MN5078
G	K5079
G	HOH5169
G	HOH5170
G	HOH5573
G	HOH5607

site_id	KC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ORN G 5081

Chain	Residue
G	GLU783
G	ASP791
G	ALA793
G	GLU892
G	VAL893
G	LEU907
G	TYR1040
G	ASP1041
G	THR1042
G	HOH5099
G	HOH5101
G	HOH5104

site_id	KC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NET G 5082

Chain	Residue
G	GLN22
G	THR94
G	ASN97

Functional Information from PROSITE/UniProt

site_id	PS00866
Number of Residues	15
Details	CPSASE_1 Carbamoyl-phosphate synthase subdomain signature 1. FPCIIRPSftmGGsG

Chain	Residue	Details
A	PHE164-GLY178
A	TYR710-ALA724

site_id	PS00867
Number of Residues	8
Details	CPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. VIEMNPRV

Chain	Residue	Details
A	VAL297-VAL304
A	LEU839-ALA846

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	780
Details	Domain: {"description":"ATP-grasp 1","evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	544
Details	Domain: {"description":"MGS-like","evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	1604
Details	Region: {"description":"Carboxyphosphate synthetic domain","evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	596
Details	Region: {"description":"Oligomerization domain","evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	544
Details	Region: {"description":"Allosteric domain","evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	72
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10029528","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1A9X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1C30","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1C3O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CE8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CS0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1JDB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KEE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M6V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T36","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10428826","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CE8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10029528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10089390","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10428826","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10587438","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9636022","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CE8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10428826","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9636022","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CE8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10029528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10089390","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10428826","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9636022","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CE8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10029528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10089390","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	4
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"HAMAP-Rule","id":"MF_01209","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	8
Details	Active site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01209","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01209","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10587438","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1C3O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
B	HIS353

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
D	HIS353

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
F	HIS353

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
H	HIS353

site_id	CSA5
Number of Residues	3
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
B	HIS353
B	CYG269
B	GLU355

site_id	CSA6
Number of Residues	3
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
D	HIS353
D	CYG269
D	GLU355

site_id	CSA7
Number of Residues	3
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
F	HIS353
F	CYG269
F	GLU355

site_id	CSA8
Number of Residues	3
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
H	HIS353
H	CYG269
H	GLU355

site_id	MCSA1
Number of Residues	3
Details	M-CSA 435

Chain	Residue	Details
B	LEU270	covalent catalysis, proton shuttle (general acid/base)
A	ARG303	electrostatic stabiliser
A	ARG715	electrostatic stabiliser
A	GLU761	steric role
A	GLN829	metal ligand
A	GLU841	metal ligand
A	ASN843	metal ligand
A	ARG848	electrostatic stabiliser
B	SER357	proton shuttle (general acid/base)
B	GLY359	steric role
A	GLU215	steric role
A	HIS243	proton shuttle (general acid/base)
A	ASN283	electrostatic stabiliser
A	GLN285	metal ligand
A	GLU299	metal ligand
A	ASN301	metal ligand

site_id	MCSA2
Number of Residues	3
Details	M-CSA 435

Chain	Residue	Details
D	LEU270	covalent catalysis, proton shuttle (general acid/base)
C	ARG303	electrostatic stabiliser
C	ARG715	electrostatic stabiliser
C	GLU761	steric role
C	GLN829	metal ligand
C	GLU841	metal ligand
C	ASN843	metal ligand
C	ARG848	electrostatic stabiliser
D	SER357	proton shuttle (general acid/base)
D	GLY359	steric role
C	GLU215	steric role
C	HIS243	proton shuttle (general acid/base)
C	ASN283	electrostatic stabiliser
C	GLN285	metal ligand
C	GLU299	metal ligand
C	ASN301	metal ligand

site_id	MCSA3
Number of Residues	3
Details	M-CSA 435

Chain	Residue	Details
F	LEU270	covalent catalysis, proton shuttle (general acid/base)
E	ARG303	electrostatic stabiliser
E	ARG715	electrostatic stabiliser
E	GLU761	steric role
E	GLN829	metal ligand
E	GLU841	metal ligand
E	ASN843	metal ligand
E	ARG848	electrostatic stabiliser
F	SER357	proton shuttle (general acid/base)
F	GLY359	steric role
E	GLU215	steric role
E	HIS243	proton shuttle (general acid/base)
E	ASN283	electrostatic stabiliser
E	GLN285	metal ligand
E	GLU299	metal ligand
E	ASN301	metal ligand

site_id	MCSA4
Number of Residues	3
Details	M-CSA 435

Chain	Residue	Details
H	LEU270	covalent catalysis, proton shuttle (general acid/base)
G	ARG303	electrostatic stabiliser
G	ARG715	electrostatic stabiliser
G	GLU761	steric role
G	GLN829	metal ligand
G	GLU841	metal ligand
G	ASN843	metal ligand
G	ARG848	electrostatic stabiliser
H	SER357	proton shuttle (general acid/base)
H	GLY359	steric role
G	GLU215	steric role
G	HIS243	proton shuttle (general acid/base)
G	ASN283	electrostatic stabiliser
G	GLN285	metal ligand
G	GLU299	metal ligand
G	ASN301	metal ligand

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)