1CRW

CRYSTAL STRUCTURE OF APO-GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE FROM PALINURUS VERSICOLOR AT 2.0A RESOLUTION

Functional Information from GO Data

Chain	GOid	namespace	contents
G	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006006	biological_process	glucose metabolic process
G	0006096	biological_process	glycolytic process
G	0016491	molecular_function	oxidoreductase activity
G	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
G	0050661	molecular_function	NADP binding
G	0051287	molecular_function	NAD binding
R	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0006006	biological_process	glucose metabolic process
R	0006096	biological_process	glycolytic process
R	0016491	molecular_function	oxidoreductase activity
R	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
R	0050661	molecular_function	NADP binding
R	0051287	molecular_function	NAD binding

Functional Information from PROSITE/UniProt

site_id	PS00071
Number of Residues	8
Details	GAPDH Glyceraldehyde 3-phosphate dehydrogenase active site. ASCTTNcL

Chain	Residue	Details
G	ALA147-LEU154

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Nucleophile

Chain	Residue	Details
G	CYS149
R	CYS149

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site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:9761850

Chain	Residue	Details
G	ARG10
G	ASP32
G	ASN313
R	ARG10
R	ASP32
R	ASN313

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site_id	SWS_FT_FI3
Number of Residues	10
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
G	MET77
R	ARG231
G	SER148
G	THR179
G	THR208
G	ARG231
R	MET77
R	SER148
R	THR179
R	THR208

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site_id	SWS_FT_FI4
Number of Residues	2
Details	SITE: Activates thiol group during catalysis

Chain	Residue	Details
G	HIS176
R	HIS176

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site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: N-acetylserine => ECO:0000250|UniProtKB:P00357

Chain	Residue	Details
G	SER1
R	SER1

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1szj

Chain	Residue	Details
G	CYS149
G	HIS176

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site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1szj

Chain	Residue	Details
R	CYS149
R	HIS176

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site_id	MCSA1
Number of Residues	2
Details	M-CSA 911

Chain	Residue	Details
G	CYS149	covalent catalysis, proton shuttle (general acid/base)
G	HIS176	proton shuttle (general acid/base)

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site_id	MCSA2
Number of Residues	2
Details	M-CSA 911

Chain	Residue	Details
R	CYS149	covalent catalysis, proton shuttle (general acid/base)
R	HIS176	proton shuttle (general acid/base)

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