Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004601 | molecular_function | peroxidase activity |
| A | 0006979 | biological_process | response to oxidative stress |
| A | 0020037 | molecular_function | heme binding |
| B | 0004601 | molecular_function | peroxidase activity |
| B | 0006979 | biological_process | response to oxidative stress |
| B | 0020037 | molecular_function | heme binding |
Functional Information from PDB Data
| site_id | COA |
| Number of Residues | 6 |
| Details | HYDROPHOBIC CHANNEL RESPONSIBLE FOR CYCLOOGENASE ACTIVITY |
| Chain | Residue |
| A | ARG120 |
| A | TYR355 |
| A | TYR385 |
| A | TRP387 |
| A | ILE523 |
| A | SER530 |
| site_id | COB |
| Number of Residues | 6 |
| Details | HYDROPHOBIC CHANNEL RESPONSIBLE FOR CYCLOOGENASE ACTIVITY |
| Chain | Residue |
| B | TRP387 |
| B | ILE523 |
| B | SER530 |
| B | ARG120 |
| B | TYR355 |
| B | TYR385 |
| site_id | POA |
| Number of Residues | 3 |
| Details | HEME POCKET RESPONSIBLE FOR PEROXIDASE ACTIVITY |
| Chain | Residue |
| A | HEM601 |
| A | HIS207 |
| A | HIS388 |
| site_id | POB |
| Number of Residues | 3 |
| Details | HEME POCKET RESPONSIBLE FOR PEROXIDASE ACTIVITY |
| Chain | Residue |
| B | HEM601 |
| B | HIS207 |
| B | HIS388 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 72 |
| Details | Transmembrane: {"description":"Helical"} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 76 |
| Details | Domain: {"description":"EGF-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00076","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor"} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Active site: {"description":"For cyclooxygenase activity","evidences":[{"source":"PubMed","id":"2122967","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"description":"axial binding residue"} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Site: {"description":"Not glycosylated","evidences":[{"source":"PubMed","id":"8349699","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Site: {"description":"Aspirin-acetylated serine"} |
| site_id | SWS_FT_FI8 |
| Number of Residues | 6 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"8349699","evidenceCode":"ECO:0000269"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1mhl |
| Chain | Residue | Details |
| A | VAL291 | |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1mhl |
| Chain | Residue | Details |
| B | VAL291 | |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1mhl |
| Chain | Residue | Details |
| A | HIS207 | |
| A | TYR385 | |
| A | GLN203 | |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1mhl |
| Chain | Residue | Details |
| B | HIS207 | |
| B | TYR385 | |
| B | GLN203 | |
