1CMX

STRUCTURAL BASIS FOR THE SPECIFICITY OF UBIQUITIN C-TERMINAL HYDROLASES

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004843	molecular_function	cysteine-type deubiquitinase activity
A	0005737	cellular_component	cytoplasm
A	0006508	biological_process	proteolysis
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0008233	molecular_function	peptidase activity
A	0008234	molecular_function	cysteine-type peptidase activity
A	0010992	biological_process	ubiquitin recycling
A	0016787	molecular_function	hydrolase activity
A	0030163	biological_process	protein catabolic process
A	0051604	biological_process	protein maturation
C	0004843	molecular_function	cysteine-type deubiquitinase activity
C	0005737	cellular_component	cytoplasm
C	0006508	biological_process	proteolysis
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0008233	molecular_function	peptidase activity
C	0008234	molecular_function	cysteine-type peptidase activity
C	0010992	biological_process	ubiquitin recycling
C	0016787	molecular_function	hydrolase activity
C	0030163	biological_process	protein catabolic process
C	0051604	biological_process	protein maturation

Functional Information from PDB Data

site_id	CAT
Number of Residues	6
Details	CYSTEINE PROTEASE

Chain	Residue
A	CYS90
A	HIS166
A	ASP181
C	CYS490
C	HIS566
C	ASP581

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Functional Information from PROSITE/UniProt

site_id	PS00140
Number of Residues	17
Details	UCH_1 Ubiquitin carboxyl-terminal hydrolase family 1 cysteine active-site. QsvkNACGlyaILHSLS

Chain	Residue	Details
A	GLN84-SER100

---

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
B	LYS327-ASP352

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	44
Details	Region: {"description":"Interaction with ubiquitin"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PROSITE-ProRule","id":"PRU01393","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10091","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PROSITE-ProRule","id":"PRU01393","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Site: {"description":"Transition state stabilizer","evidences":[{"source":"PROSITE-ProRule","id":"PRU01393","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Site: {"description":"Important for enzyme activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01393","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	5
Details	a catalytic site defined by CSA, PubMed 10406793, 8639624

Chain	Residue	Details
A	ASP181
A	CYS90
A	CYS90
A	HIS166
A	GLN84

---

site_id	CSA2
Number of Residues	5
Details	a catalytic site defined by CSA, PubMed 10406793, 8639624

Chain	Residue	Details
C	HIS566
C	CYS490
C	CYS490
C	GLN484
C	ASP581

---