1CMV
HUMAN CYTOMEGALOVIRUS PROTEASE
Functional Information from GO Data
Functional Information from PDB Data
| site_id | ACA |
| Number of Residues | 3 |
| Details | CATALYTIC SITE FOR CHAIN A. |
| Chain | Residue |
| A | SER132 |
| A | HIS63 |
| A | HIS157 |
| site_id | ACB |
| Number of Residues | 3 |
| Details | CATALYTIC SITE FOR CHAIN B. |
| Chain | Residue |
| B | SER132 |
| B | HIS63 |
| B | HIS157 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | ACT_SITE: Charge relay system => ECO:0000255|HAMAP-Rule:MF_04008 |
| Chain | Residue | Details |
| A | HIS63 | |
| A | SER132 | |
| A | HIS157 | |
| B | HIS63 | |
| B | SER132 | |
| B | HIS157 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | SITE: Cleavage; by assemblin; Release site => ECO:0000255|HAMAP-Rule:MF_04008 |
| Chain | Residue | Details |
| A | ALA256 | |
| B | ALA256 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 6 |
| Details | M-CSA 238 |
| Chain | Residue | Details |
| A | HIS63 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | SER132 | covalently attached, hydrogen bond acceptor, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor |
| A | SER134 | hydrogen bond donor, increase acidity, increase basicity |
| A | HIS157 | electrostatic stabiliser, hydrogen bond acceptor, increase acidity, increase basicity |
| A | ARG165 | electrostatic stabiliser, hydrogen bond donor |
| A | ARG166 | electrostatic stabiliser, hydrogen bond donor |
| site_id | MCSA2 |
| Number of Residues | 6 |
| Details | M-CSA 238 |
| Chain | Residue | Details |
| B | HIS63 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| B | SER132 | covalently attached, hydrogen bond acceptor, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor |
| B | SER134 | hydrogen bond donor, increase acidity, increase basicity |
| B | HIS157 | electrostatic stabiliser, hydrogen bond acceptor, increase acidity, increase basicity |
| B | ARG165 | electrostatic stabiliser, hydrogen bond donor |
| B | ARG166 | electrostatic stabiliser, hydrogen bond donor |
