Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0019430 | biological_process | removal of superoxide radicals |
| A | 0045454 | biological_process | cell redox homeostasis |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| A | 1902515 | cellular_component | thioredoxin-disulfide reductase complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 37 |
| Details | BINDING SITE FOR RESIDUE FAD A 500 |
| Chain | Residue |
| A | GLY12 |
| A | GLU38 |
| A | GLY41 |
| A | GLN42 |
| A | LEU43 |
| A | THR46 |
| A | VAL49 |
| A | ASN51 |
| A | HIS83 |
| A | ILE84 |
| A | ALA111 |
| A | SER13 |
| A | THR112 |
| A | GLY113 |
| A | SER133 |
| A | ALA134 |
| A | CYS138 |
| A | ASN248 |
| A | GLY285 |
| A | ASP286 |
| A | ARG293 |
| A | GLN294 |
| A | GLY14 |
| A | ALA295 |
| A | SER298 |
| A | HOH617 |
| A | HOH620 |
| A | HOH640 |
| A | HOH643 |
| A | HOH644 |
| A | HOH668 |
| A | PRO15 |
| A | ALA16 |
| A | TYR23 |
| A | THR35 |
| A | GLY36 |
| A | MET37 |
Functional Information from PROSITE/UniProt
| site_id | PS00573 |
| Number of Residues | 21 |
| Details | PYRIDINE_REDOX_2 Pyridine nucleotide-disulphide oxidoreductases class-II active site. CatCDGff..YrnqkVaVIGGGN |
| Chain | Residue | Details |
| A | CYS135-ASN155 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | GLY36 | |
| A | VAL287 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1tde |
| Chain | Residue | Details |
| A | CYS135 | |
| A | CYS138 | |
| A | ASP139 | |
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 381 |
| Chain | Residue | Details |
| A | ALA136 | covalent catalysis, proton shuttle (general acid/base) |
| A | ASP139 | covalent catalysis, proton shuttle (general acid/base) |
| A | GLY140 | proton shuttle (general acid/base) |
