1CKS

HUMAN CKSHS2 ATOMIC STRUCTURE: A ROLE FOR ITS HEXAMERIC ASSEMBLY IN CELL CYCLE CONTROL

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
A	0003682	molecular_function	chromatin binding
A	0005515	molecular_function	protein binding
A	0006357	biological_process	regulation of transcription by RNA polymerase II
A	0007127	biological_process	meiosis I
A	0007346	biological_process	regulation of mitotic cell cycle
A	0016538	molecular_function	cyclin-dependent protein serine/threonine kinase regulator activity
A	0019005	cellular_component	SCF ubiquitin ligase complex
A	0019901	molecular_function	protein kinase binding
A	0042393	molecular_function	histone binding
A	0043130	molecular_function	ubiquitin binding
A	0044772	biological_process	mitotic cell cycle phase transition
A	0048144	biological_process	fibroblast proliferation
A	0051301	biological_process	cell division
A	0061575	molecular_function	cyclin-dependent protein serine/threonine kinase activator activity
B	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
B	0003682	molecular_function	chromatin binding
B	0005515	molecular_function	protein binding
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0007127	biological_process	meiosis I
B	0007346	biological_process	regulation of mitotic cell cycle
B	0016538	molecular_function	cyclin-dependent protein serine/threonine kinase regulator activity
B	0019005	cellular_component	SCF ubiquitin ligase complex
B	0019901	molecular_function	protein kinase binding
B	0042393	molecular_function	histone binding
B	0043130	molecular_function	ubiquitin binding
B	0044772	biological_process	mitotic cell cycle phase transition
B	0048144	biological_process	fibroblast proliferation
B	0051301	biological_process	cell division
B	0061575	molecular_function	cyclin-dependent protein serine/threonine kinase activator activity
C	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
C	0003682	molecular_function	chromatin binding
C	0005515	molecular_function	protein binding
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0007127	biological_process	meiosis I
C	0007346	biological_process	regulation of mitotic cell cycle
C	0016538	molecular_function	cyclin-dependent protein serine/threonine kinase regulator activity
C	0019005	cellular_component	SCF ubiquitin ligase complex
C	0019901	molecular_function	protein kinase binding
C	0042393	molecular_function	histone binding
C	0043130	molecular_function	ubiquitin binding
C	0044772	biological_process	mitotic cell cycle phase transition
C	0048144	biological_process	fibroblast proliferation
C	0051301	biological_process	cell division
C	0061575	molecular_function	cyclin-dependent protein serine/threonine kinase activator activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 300

Chain	Residue
A	LYS11
A	ARG20
A	GLN50
A	SER51
A	TRP54
C	ALA2
C	HOH558

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site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 B 301

Chain	Residue
B	LYS11
B	ARG20
B	GLN50
B	SER51
B	TRP54
A	ARG71
B	ALA2

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site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 C 302

Chain	Residue
A	ALA2
A	LYS4
A	HOH374
C	ARG20
C	GLN50
C	SER51
C	HOH708

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Functional Information from PROSITE/UniProt

site_id	PS00944
Number of Residues	19
Details	CKS_1 Cyclin-dependent kinases regulatory subunits signature 1. YSdKYfDEhYEYRHVmLPR

Chain	Residue	Details
A	TYR8-ARG26

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site_id	PS00945
Number of Residues	11
Details	CKS_2 Cyclin-dependent kinases regulatory subunits signature 2. HePEpHILLFR

Chain	Residue	Details
A	HIS60-ARG70

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS4
B	LYS4
C	LYS4

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