1CK7
GELATINASE A (FULL-LENGTH)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001525 | biological_process | angiogenesis |
| A | 0001541 | biological_process | ovarian follicle development |
| A | 0001542 | biological_process | ovulation from ovarian follicle |
| A | 0001553 | biological_process | luteinization |
| A | 0001666 | biological_process | response to hypoxia |
| A | 0001955 | biological_process | blood vessel maturation |
| A | 0001957 | biological_process | intramembranous ossification |
| A | 0001968 | molecular_function | fibronectin binding |
| A | 0004175 | molecular_function | endopeptidase activity |
| A | 0004222 | molecular_function | metalloendopeptidase activity |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006508 | biological_process | proteolysis |
| A | 0006979 | biological_process | response to oxidative stress |
| A | 0007162 | biological_process | negative regulation of cell adhesion |
| A | 0007507 | biological_process | heart development |
| A | 0007565 | biological_process | female pregnancy |
| A | 0007566 | biological_process | embryo implantation |
| A | 0007567 | biological_process | parturition |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0009410 | biological_process | response to xenobiotic stimulus |
| A | 0009612 | biological_process | response to mechanical stimulus |
| A | 0014012 | biological_process | peripheral nervous system axon regeneration |
| A | 0014823 | biological_process | response to activity |
| A | 0016020 | cellular_component | membrane |
| A | 0016477 | biological_process | cell migration |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0022617 | biological_process | extracellular matrix disassembly |
| A | 0030017 | cellular_component | sarcomere |
| A | 0030163 | biological_process | protein catabolic process |
| A | 0030198 | biological_process | extracellular matrix organization |
| A | 0030335 | biological_process | positive regulation of cell migration |
| A | 0030574 | biological_process | collagen catabolic process |
| A | 0031012 | cellular_component | extracellular matrix |
| A | 0032526 | biological_process | response to retinoic acid |
| A | 0034097 | biological_process | response to cytokine |
| A | 0034614 | biological_process | cellular response to reactive oxygen species |
| A | 0035094 | biological_process | response to nicotine |
| A | 0035987 | biological_process | endodermal cell differentiation |
| A | 0042542 | biological_process | response to hydrogen peroxide |
| A | 0043065 | biological_process | positive regulation of apoptotic process |
| A | 0043627 | biological_process | response to estrogen |
| A | 0045906 | biological_process | negative regulation of vasoconstriction |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048013 | biological_process | ephrin receptor signaling pathway |
| A | 0048246 | biological_process | macrophage chemotaxis |
| A | 0048661 | biological_process | positive regulation of smooth muscle cell proliferation |
| A | 0048705 | biological_process | skeletal system morphogenesis |
| A | 0048771 | biological_process | tissue remodeling |
| A | 0051602 | biological_process | response to electrical stimulus |
| A | 0055093 | biological_process | response to hyperoxia |
| A | 0060325 | biological_process | face morphogenesis |
| A | 0060346 | biological_process | bone trabecula formation |
| A | 0060740 | biological_process | prostate gland epithelium morphogenesis |
| A | 0061450 | biological_process | trophoblast cell migration |
| A | 0071230 | biological_process | cellular response to amino acid stimulus |
| A | 0071345 | biological_process | cellular response to cytokine stimulus |
| A | 0071347 | biological_process | cellular response to interleukin-1 |
| A | 0071392 | biological_process | cellular response to estradiol stimulus |
| A | 0071492 | biological_process | cellular response to UV-A |
| A | 0071498 | biological_process | cellular response to fluid shear stress |
| A | 1903378 | biological_process | positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway |
| A | 1904645 | biological_process | response to amyloid-beta |
| A | 1904707 | biological_process | positive regulation of vascular associated smooth muscle cell proliferation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 990 |
| Chain | Residue |
| A | CYS102 |
| A | HIS403 |
| A | HIS407 |
| A | HIS413 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 991 |
| Chain | Residue |
| A | HIS178 |
| A | ASP180 |
| A | HIS193 |
| A | HIS206 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 992 |
| Chain | Residue |
| A | ASP185 |
| A | GLY186 |
| A | ASP188 |
| A | LEU190 |
| A | ASP208 |
| A | GLU211 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 993 |
| Chain | Residue |
| A | GLU166 |
| A | ALA167 |
| A | ASP168 |
| A | GLY200 |
| A | GLY202 |
| A | ASP204 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA A 994 |
| Chain | Residue |
| A | ASP476 |
| A | ASP521 |
| A | ASP569 |
| A | ASP618 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 995 |
| Chain | Residue |
| A | ALA522 |
| A | VAL523 |
| A | ALA571 |
| A | NA996 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 996 |
| Chain | Residue |
| A | ILE478 |
| A | ALA479 |
| A | VAL523 |
| A | ALA571 |
| A | VAL620 |
| A | CL995 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 777 |
| Chain | Residue |
| A | GLN52 |
| A | TYR53 |
| A | THR56 |
| A | PHE57 |
| A | ASP185 |
| A | LEU190 |
| A | HOH1097 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 778 |
| Chain | Residue |
| A | GLN298 |
| A | GLY299 |
| A | THR300 |
| A | THR307 |
| site_id | CAA |
| Number of Residues | 6 |
| Details | CA 992 CATALYTIC DOMAIN |
| Chain | Residue |
| A | GLY186 |
| A | ASP188 |
| A | LEU190 |
| A | ASP208 |
| A | GLU211 |
| A | ASP185 |
| site_id | CAB |
| Number of Residues | 6 |
| Details | CA 993 CATALYTIC DOMAIN |
| Chain | Residue |
| A | GLU166 |
| A | ALA167 |
| A | ASP168 |
| A | GLY200 |
| A | GLY202 |
| A | ASP204 |
| site_id | CAH |
| Number of Residues | 4 |
| Details | CA 994 HEMOPEXIN DOMAIN |
| Chain | Residue |
| A | ASP476 |
| A | ASP521 |
| A | ASP569 |
| A | ASP618 |
| site_id | ZNA |
| Number of Residues | 4 |
| Details | ZN 990 ACTIVE SITE |
| Chain | Residue |
| A | CYS102 |
| A | HIS403 |
| A | HIS407 |
| A | HIS413 |
| site_id | ZNS |
| Number of Residues | 4 |
| Details | ZN 991 STRUCTURAL SITE |
| Chain | Residue |
| A | ASP180 |
| A | HIS178 |
| A | HIS193 |
| A | HIS206 |
Functional Information from PROSITE/UniProt
| site_id | PS00023 |
| Number of Residues | 42 |
| Details | FN2_1 Fibronectin type-II collagen-binding domain signature. CkfPFlFngkeynsCtdtgrsdgflWCsttyNFekdgkYgFC |
| Chain | Residue | Details |
| A | CYS233-CYS274 | |
| A | CYS291-CYS332 | |
| A | CYS349-CYS390 |
| site_id | PS00024 |
| Number of Residues | 16 |
| Details | HEMOPEXIN Hemopexin domain signature. IAdaWnaiPdNLDAVV |
| Chain | Residue | Details |
| A | ILE606-VAL621 |
| site_id | PS00546 |
| Number of Residues | 8 |
| Details | CYSTEINE_SWITCH Matrixins cysteine switch. PRCGnPDV |
| Chain | Residue | Details |
| A | PRO100-VAL107 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000305|PubMed:10356396 |
| Chain | Residue | Details |
| A | ALA404 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: in inhibited form => ECO:0000269|PubMed:10356396, ECO:0000269|PubMed:12032297, ECO:0007744|PDB:1CK7, ECO:0007744|PDB:1EAK, ECO:0007744|PDB:1GXD |
| Chain | Residue | Details |
| A | CYS102 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21813640, ECO:0007744|PDB:1QIB, ECO:0007744|PDB:3AYU |
| Chain | Residue | Details |
| A | ASP134 | |
| A | ASP209 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21813640, ECO:0007744|PDB:1EAK, ECO:0007744|PDB:3AYU |
| Chain | Residue | Details |
| A | ASP168 | |
| A | GLY200 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10356396, ECO:0000269|PubMed:12032297, ECO:0000269|PubMed:21813640, ECO:0007744|PDB:1CK7, ECO:0007744|PDB:1EAK, ECO:0007744|PDB:1GXD, ECO:0007744|PDB:1QIB, ECO:0007744|PDB:3AYU |
| Chain | Residue | Details |
| A | HIS178 | |
| A | ASP180 | |
| A | HIS193 | |
| A | HIS206 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21813640, ECO:0007744|PDB:3AYU |
| Chain | Residue | Details |
| A | ASP185 | |
| A | GLY186 | |
| A | GLY202 | |
| A | ASP204 | |
| A | ASP208 | |
| A | GLU211 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10356396, ECO:0000269|PubMed:12032297, ECO:0000269|PubMed:21813640, ECO:0007744|PDB:1CK7, ECO:0007744|PDB:1EAK, ECO:0007744|PDB:1GXD, ECO:0007744|PDB:3AYU |
| Chain | Residue | Details |
| A | HIS403 | |
| A | HIS407 | |
| A | HIS413 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10356396, ECO:0000269|PubMed:8549817, ECO:0007744|PDB:1CK7, ECO:0007744|PDB:1RTG |
| Chain | Residue | Details |
| A | ASP476 | |
| A | ASP521 | |
| A | ASP569 | |
| A | ASP618 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN573 | |
| A | ASN642 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | a catalytic site defined by CSA, PubMed 9785958, 12401069 |
| Chain | Residue | Details |
| A | ALA404 |
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 906 |
| Chain | Residue | Details |
| A | HIS403 | metal ligand |
| A | ALA404 | proton shuttle (general acid/base) |
| A | HIS407 | metal ligand |
| A | HIS413 | metal ligand |
