1CJW
SEROTONIN N-ACETYLTRANSFERASE COMPLEXED WITH A BISUBSTRATE ANALOG
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE COT A 400 |
| Chain | Residue |
| A | PHE56 |
| A | VAL126 |
| A | ARG131 |
| A | GLN132 |
| A | GLN133 |
| A | GLY134 |
| A | LYS135 |
| A | GLY136 |
| A | SER137 |
| A | ARG154 |
| A | MET159 |
| A | SER60 |
| A | CYS160 |
| A | ALA163 |
| A | LEU164 |
| A | PHE167 |
| A | TYR168 |
| A | ARG170 |
| A | HOH1016 |
| A | HOH1020 |
| A | HOH1021 |
| A | HOH1261 |
| A | ASN62 |
| A | CYS63 |
| A | PRO64 |
| A | HIS122 |
| A | ALA123 |
| A | LEU124 |
| A | ALA125 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10319816","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11336675","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11902838","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11336675","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11884405","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11902838","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Site: {"description":"Important for the catalytic mechanism; involved in substrate deprotonation","evidences":[{"source":"PubMed","id":"10319816","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11884405","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine; by PKA","evidences":[{"source":"PubMed","id":"11427721","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14578935","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15644438","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1b6b |
| Chain | Residue | Details |
| A | SER97 | |
| A | LEU111 | |
| A | HIS122 | |
| A | LEU124 | |
| A | TYR168 |
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 22 |
| Chain | Residue | Details |
| A | SER97 | activator, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor |
| A | LEU111 | hydrogen bond acceptor, steric role |
| A | HIS122 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | LEU124 | electrostatic stabiliser, hydrogen bond donor |
| A | TYR168 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
