1CJW
SEROTONIN N-ACETYLTRANSFERASE COMPLEXED WITH A BISUBSTRATE ANALOG
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 29 |
Details | BINDING SITE FOR RESIDUE COT A 400 |
Chain | Residue |
A | PHE56 |
A | VAL126 |
A | ARG131 |
A | GLN132 |
A | GLN133 |
A | GLY134 |
A | LYS135 |
A | GLY136 |
A | SER137 |
A | ARG154 |
A | MET159 |
A | SER60 |
A | CYS160 |
A | ALA163 |
A | LEU164 |
A | PHE167 |
A | TYR168 |
A | ARG170 |
A | HOH1016 |
A | HOH1020 |
A | HOH1021 |
A | HOH1261 |
A | ASN62 |
A | CYS63 |
A | PRO64 |
A | HIS122 |
A | ALA123 |
A | LEU124 |
A | ALA125 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11336675, ECO:0000269|PubMed:11884405, ECO:0000269|PubMed:11902838 |
Chain | Residue | Details |
A | LEU124 | |
A | MET159 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:10319816, ECO:0000269|PubMed:11336675, ECO:0000269|PubMed:11902838 |
Chain | Residue | Details |
A | GLN132 | |
A | TYR168 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | SITE: Important for the catalytic mechanism; involved in substrate deprotonation => ECO:0000269|PubMed:10319816, ECO:0000269|PubMed:11884405 |
Chain | Residue | Details |
A | HIS120 | |
A | HIS122 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | MOD_RES: Phosphothreonine; by PKA => ECO:0000269|PubMed:11427721, ECO:0000269|PubMed:14578935, ECO:0000269|PubMed:15644438 |
Chain | Residue | Details |
A | THR31 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 5 |
Details | Annotated By Reference To The Literature 1b6b |
Chain | Residue | Details |
A | SER97 | |
A | LEU111 | |
A | HIS122 | |
A | LEU124 | |
A | TYR168 |
site_id | MCSA1 |
Number of Residues | 5 |
Details | M-CSA 22 |
Chain | Residue | Details |
A | SER97 | activator, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor |
A | LEU111 | hydrogen bond acceptor, steric role |
A | HIS122 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
A | LEU124 | electrostatic stabiliser, hydrogen bond donor |
A | TYR168 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |