Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

1CJL

CRYSTAL STRUCTURE OF A CYSTEINE PROTEASE PROFORM

Functional Information from GO Data
ChainGOidnamespacecontents
A0001968molecular_functionfibronectin binding
A0002250biological_processadaptive immune response
A0004197molecular_functioncysteine-type endopeptidase activity
A0005515molecular_functionprotein binding
A0005518molecular_functioncollagen binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005764cellular_componentlysosome
A0005771cellular_componentmultivesicular body
A0005794cellular_componentGolgi apparatus
A0005886cellular_componentplasma membrane
A0006508biological_processproteolysis
A0006955biological_processimmune response
A0008234molecular_functioncysteine-type peptidase activity
A0008656molecular_functioncysteine-type endopeptidase activator activity involved in apoptotic process
A0016324cellular_componentapical plasma membrane
A0016540biological_processprotein autoprocessing
A0019064biological_processfusion of virus membrane with host plasma membrane
A0019065biological_processreceptor-mediated endocytosis of virus by host cell
A0019882biological_processantigen processing and presentation
A0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
A0030574biological_processcollagen catabolic process
A0031410cellular_componentcytoplasmic vesicle
A0031638biological_processzymogen activation
A0034230biological_processenkephalin processing
A0036021cellular_componentendolysosome lumen
A0039654biological_processfusion of virus membrane with host endosome membrane
A0042393molecular_functionhistone binding
A0042583cellular_componentchromaffin granule
A0043202cellular_componentlysosomal lumen
A0043231cellular_componentintracellular membrane-bounded organelle
A0043373biological_processCD4-positive, alpha-beta T cell lineage commitment
A0043394molecular_functionproteoglycan binding
A0046718biological_processsymbiont entry into host cell
A0048002biological_processantigen processing and presentation of peptide antigen
A0051603biological_processproteolysis involved in protein catabolic process
A0060309biological_processelastin catabolic process
A0062023cellular_componentcollagen-containing extracellular matrix
A0070062cellular_componentextracellular exosome
A0071682cellular_componentendocytic vesicle lumen
A0071888biological_processmacrophage apoptotic process
A0097067biological_processcellular response to thyroid hormone stimulus
A0097655molecular_functionserpin family protein binding
A2001235biological_processpositive regulation of apoptotic signaling pathway
Functional Information from PDB Data
site_idACT
Number of Residues3
DetailsCATALYTIC TRIAD (CYS 25 IS MUTATED TO SER).
ChainResidue
ASER25
AHIS163
AASN187

Functional Information from PROSITE/UniProt
site_idPS00639
Number of Residues11
DetailsTHIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. MDHGVLVVGYG
ChainResidueDetails
AMET161-GLY171

site_idPS00640
Number of Residues20
DetailsTHIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. YWLvKNSWgeeWGmgGYVkM
ChainResidueDetails
ATYR182-MET201

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: ACT_SITE => ECO:0000305|PubMed:9468501
ChainResidueDetails
ASER25

site_idSWS_FT_FI2
Number of Residues2
DetailsACT_SITE:
ChainResidueDetails
AHIS163
AASN187

site_idSWS_FT_FI3
Number of Residues4
DetailsSITE: Cleavage; by autolysis => ECO:0000269|PubMed:9468501
ChainResidueDetails
APHE89
AGLN90
ATYR95
AGLU96

site_idSWS_FT_FI4
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218
ChainResidueDetails
AASN108

227111

PDB entries from 2024-11-06

PDB statisticsPDBj update infoContact PDBjnumon